- Tytuł:
- A computational approach to structural properties of glycoside hydrolase family 4 from bacteria
- Autorzy:
-
Craciun, Dana
Vlad-Oros, Beatrice
Filimon, Nicoleta
Ostafe, Vasile
Isvoran, Adriana - Powiązania:
- https://bibliotekanauki.pl/articles/1039444.pdf
- Data publikacji:
- 2013
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
glycosidases
structural properties
specific interactions - Opis:
- Structural bioinformatics approaches applied to the alpha- and beta-glycosidases from the GH4 enzyme family reveal that, despite low sequence identity, these enzymes possess quite similar global structural characteristics reflecting a common reaction mechanism. Locally, there are a few distinctive structural characteristics of GH4 alpha- and beta-glycosidases, namely, surface cavities with different geometric characteristics and two regions with highly dissimilar structural organizations and distinct physicochemical properties in the alpha- and beta-glucosidases from Thermotoga maritima. We suggest that these structurally dissimilar regions may be involved in specific protein-protein interactions and this hypothesis is sustained by the predicted distinct functional partners of the investigated proteins. Also, we predict that alpha- and beta-glycosidases from the GH4 enzyme family interact with difenoconazole, a fungicide, but there are different features of these interactions especially concerning the identified structurally distinct regions of the investigated proteins.
- Źródło:
-
Acta Biochimica Polonica; 2013, 60, 4; 553-564
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł