- Tytuł:
- Therapeutical effect of modified adamantane copolymer compounds: Study of molecular mechanisms.
- Autorzy:
-
Rybalko, Svitlana
Nesterova, Nadiya
Diadiun, Svitlana
Danylenko, Grygori
Danylenko, Valentyna
Guzhova, Svitlana
Maksimov, Yuri
Arkadiev, Viatcheslav
Ivans'ka, Naila
Maksymenok, Olena
Vrnycianu, Nina
Zhtrebtsova, Ella
Grygoreva, Tanya - Powiązania:
- https://bibliotekanauki.pl/articles/1044193.pdf
- Data publikacji:
- 2001
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
N-polyvinylpyrrolidone-acrylic acid copolymers
anti-viral therapy
adamantane derivatives - Opis:
- Copolymers of N-polyvinylpyrrolidone-acrylic acid (AB-1) and adamantane derivatives are known to possess marked antiviral activity in in vitro and in ovo models. Among the constructed preparations of AB-1 modified by adamantane derivatives some, especially AB-4 (modified by deitiforin), were found to show more extended antiviral activity and to inhibit markedly virus reproduction in susceptible permissive cell cultures and chicken embryos. In AB-4 treated cells and allantoic sacs, virus titers (influenza virus, herpes virus, and HIV) and virus antigen concentration were decreased. On the other hand, herpes virus-specific thymidine kinase and of DNA-polymerases isolated from Escherichia coli, Plectonema boryanum, and herpes virus type 1 infected murine brain tissue retained their activity after incubation with AB-4 or AB-2. The compounds investigated, in view of their effect on virus reproduction, are thought to be prospective as antiviral agents.
- Źródło:
-
Acta Biochimica Polonica; 2001, 48, 1; 241-249
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł