Temat: Retinol - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Background level of 8-oxo-2-deoxyguanosine in lymphocyte DNA does not correlate with the concentration of antioxidant vitamins in blood plasma.
Autorzy:: Gackowski, Daniel
Ciecierski, Marek
Jawień, Arkadiusz
Oliński, Ryszard
Powiązania:: https://bibliotekanauki.pl/articles/1044149.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: α-tocopherol
ascorbic acid
retinol
8-oxo-2'-deoxyguanosine
Opis:: Antioxidant vitamins, being effective free radical scavengers, can protect cellular DNA from oxidative damage. Therefore, in the present study we report on the relationship between basal level of 8-oxo-2'-deoxyguanosine in human lymphocyte DNA and the concentration of antioxidant vitamins (A, C and E). The average level of 8-oxo-2'-deoxyguanosine in lymphocytes of the studied group (15 males and 20 females) was 9.57 per 106 dG molecules. The endogenous level of ascorbic acid (vitamin C) in the plasma was, on average, 56.78 μM, while the mean concentrations of retinol (vitamin A) and α-tocopherol (vitamin E) were 1.24 μM and 25.74 μM, respectively. No correlations were found between individual 8-oxo-2'-deoxyguanosine levels in lymphocyte DNA and endogenous concentration of the vitamins.
Źródło:: Acta Biochimica Polonica; 2001, 48, 2; 535-539
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 2.

Tytuł:: The HPV16 E2 transcriptional regulator mode of action depends on the physical state of the viral genome
Autorzy:: Schmidt, Marcin
Olejnik, Agnieszka
Goździcka-Józefiak, Anna
Powiązania:: https://bibliotekanauki.pl/articles/1041324.pdf
Data publikacji:: 2005
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: E2
chromatin
transcription
HPV
retinol
steroid hormones
LCR
Opis:: Human papillomavirus (HPV) infection is a major risk factor for the development of cervical cancer. The HPV-induced immortalization of epithelial cell usually requires integration of the viral DNA into the host cell genome. The integration event causes disruption of the E2 gene and this is followed by overexpression of the E6 and E7 oncoproteins. The E2 protein is a transcription factor that regulates expression of the E6 and E7 oncoproteins by binding to four sites within the viral long control region. We used an in vitro cell culture model to explore the role of the E2 protein in the transcriptional control of the HPV16 long control region. Employing transient and stable transfection experiments we simulated the episomal and integrated states of the viral genome, respectively. We show that the E2 protein up-regulates E6/E7 transcription from episomal DNA but represses it in the case of integrated DNA. The activator function of the E2 protein seems to counteract the repressive chromatin structure formed over episomal DNA. Steroid hormones and retinol also modulate oncogene transcription differently depending on the physical structure of the viral DNA. Our data suggest regulatory mechanisms involving interactions between the E2 protein and nuclear hormone receptors.
Źródło:: Acta Biochimica Polonica; 2005, 52, 4; 823-832
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Informacja

Wyszukujesz frazę "Retinol" wg kryterium: Temat

Źródło danych

Dostawca treści

Kolekcja

Rok wydania

Wydawca

Temat

Autor

Typ dokumentu

Język