Temat: K4 - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: H3K4 histone methylation in oral squamous cell carcinoma
Autorzy:: Mancuso, Marta
Matassa, Danilo
Conte, Mariachiara
Colella, Giuseppe
Rana, Gina
Fucci, Laura
Piscopo, Marina
Powiązania:: https://bibliotekanauki.pl/articles/1040528.pdf
Data publikacji:: 2009
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: oral squamous carcinoma
histone methylation
H3K4
Opis:: Methylation of specific lysine residues in histone tails has been proposed to function as a stable epigenetic marker that directs biological functions altering chromatin structure. Recent findings have implicated alteration in heterochromatin formation as a contributing factor in cancer development. In order to verify whether changes in the overall level of H3K4 histone methylation could be involved in oral squamous carcinoma, the levels of H3K4me1, me2 and me3 were measured in oral squamous carcinoma, leukoplakias and normal tissues. The levels of H3K4me2 and me3 were significantly different in oral squamous cell carcinoma in comparison with normal tissue: the level of H3K4me2 was increased while that of H3K4me3 decreased. No significant differences could be found between the two types of tissues in the level of H3K4me1. A similar trend was found in the leukoplakias that appeared more like the pathological than normal tissue. These results support the idea that alteration of chromatin structure could contribute to oncogenic potential.
Źródło:: Acta Biochimica Polonica; 2009, 56, 3; 405-410
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Reversion of argE3 to Arg+ in Escherichia coli AB1157 -an informative bacterial system for mutation detection
Autorzy:: Sikora, Anna
Grzesiuk, Elżbieta
Powiązania:: https://bibliotekanauki.pl/articles/1040308.pdf
Data publikacji:: 2010
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: mutations
Arg+ revertants
Escherichia coli K12
prototrophy
T4 phages
suppressor tRNA
Opis:: This review concerns reversion of the argE3 (ochre) nonsense mutation to prototrophy in E. coli AB1157 strain as an informative system for mutation detection. Strain AB1157 bears the argE3 (ochre), hisG4 (ochre) and thr-1 (amber) mutations, and the supE44 amber suppressor on its chromosome. The Arg+ phenotype can be restored by (i) any base substitution at the argE3 site that changes the nonsense UAA codon to any sense nucleotide triplet or to UAG recognized by the supE44 amber suppressor, or (ii) suppressor mutations enabling the reading of the UAA nonsense codon. The argE3 → Arg+ reversion-based system enables (i) determination of the spontaneous or induced mutation level; (ii) determination of base substitutions (suppressor analysis); (iii) examination of transcription-coupled repair (TCR) since targets for DNA damage are situated on the transcribed or coding strand of DNA; (iv) detection of mutations resulting from single stranded DNA damage. This review focuses on studies carried out since the early 1990s till now with the application of the AB1157-based mutation detection system. Recently, the system has been used to obtain new data on the processes of methyl methanesulfonate-induced mutagenesis and DNA repair in E. coli alkB- mutants.
Źródło:: Acta Biochimica Polonica; 2010, 57, 4; 479-485
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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