Temat: Interferon - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Mechanisms of type I interferon action and its role in infections and diseases transmission in mammals
Autorzy:: Niedźwiedzka-Rystwej, Paulina
Tokarz-Deptuła, Beata
Deptuła, Wiesław
Powiązania:: https://bibliotekanauki.pl/articles/1038631.pdf
Data publikacji:: 2017
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: interferon
signaling pathway
infection
mammal
Opis:: Interferons (IFNs) are pivotal regulators of immunological processes. This paper describes mainly type I interferons -α and -β and their recently recounted signaling pathways, especially connected with ISGs - interferon stimulated genes, having a crucial role in regulating IFN recruitment. Moreover, the paper shows the data on the role of interferons -α and -β in infections - not only commonly known viral infections, but also bacterial, fungal and parasitic.
Źródło:: Acta Biochimica Polonica; 2017, 64, 2; 199-205
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Sustained virologic response and IL28B single-nucleotide polymorphisms in patients with chronic hepatitis C treated with pegylated interferon alfa and ribavirin
Autorzy:: Jabłonowska, Elżbieta
Piekarska, Anna
Koślińska-Berkan, Ewa
Omulecka, Aleksandra
Szymańska, Bożena
Wójcik, Kamila
Powiązania:: https://bibliotekanauki.pl/articles/1039705.pdf
Data publikacji:: 2012
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: ribavirin
interferon
HCV
IL28B
HIV
sustained virologic response
Opis:: Introduction. Hepatitis C virus (HCV) infection is a global health problem which can lead to liver cirrhosis or hepatocellular carcinoma in one-fifth of chronically infected patients. Materials and methods. The study group consisted of 123 patients: 90 with HCV mono- and 33 with HIV/HCV co-infection, who were treated with pegylated interferon alfa (Peg-IFN-α) and ribavirin. We analyzed selected pretreatment factors: age, sex, HIV/HCV co-infection, grade of inflammation, necrotic changes and fibrosis in histological analysis of liver bioptates, HCV viral load, HCV genotypes, and single nucleotide polymorphisms (SNPs) of IL28B and tried to find out which of them influence sustained virological response (SVR). The IL28B SNP C/T (rs12979860) was analyzed using Custom® SNP Genotyping Assays (Applied Biosystems). Results. Multivariate analysis demonstrated that after adjusting for the other variables three predictors independently influence SVR, namely genotype 3 of HCV, presence of the CC genotype and age >40 years (OR respectively 15.14, 3.62, and 0.36). HCV mono-infected patients were infected with HCV genotype 3 or 4 less frequently (p=0.0001) compared to HIV/HCV co-infected individuals. In patients with HIV/HCV co-infection the CC variant occurred more frequently whereas CT was found less frequently (p=0.001, p=0.0146, respectively). In patients with HIV/HCV co-infection, 3 and 4 genotype of HCV occurred more frequently compared to patients with HCV mono-infection (p=0.0001). Conclusions. These data suggest that age, HCV genotype and IL28B polymorphism are useful for prediction of the response to treatment with Peg-IFN-α and ribavirin. The more frequent occurrence of HCV genotypes 3 or 4 in patients with HIV/HCV co-infection could be associated with the route of transmission.
Źródło:: Acta Biochimica Polonica; 2012, 59, 3; 333-337
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Up-regulation of human PNPase mRNA by β-interferon has no effect on protein level in melanoma cell lines
Autorzy:: Gewartowski, Kamil
Tomecki, Rafal
Muchowski, Lukasz
Dmochowska, Aleksandra
Dzwonek, Artur
Malecki, Michal
Skurzak, Henryk
Ostrowski, Jerzy
Stepien, Piotr
Powiązania:: https://bibliotekanauki.pl/articles/1041287.pdf
Data publikacji:: 2006
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: polynucleotide phosphorylase
melanoma
human mitochondria
beta interferon
poly(A) tails
PNPase
Opis:: Human mitochondrial polynucleotide phosphorylase (hPNPase) is an exoribonuclease localized in mitochondria. The exact physiological function of this enzyme is unknown. Recent studies have revealed the existence of a relationship between induction of hPNPase mRNA and both cellular senescence and growth arrest of melanoma cells following β-interferon treatment. The aim of this study was to verify whether the augmented hPNPase mRNA level results in increase of the protein level. In several cell lines established from five metastatic melanoma patients we did not find any such correlation. However, an elevated level of hPNPase protein was observed in interferon-induced HeLa and Jurkat cells. This increase was correlated with a slight shortening of poly(A) tails of mitochondrial ND3 transcript.
Źródło:: Acta Biochimica Polonica; 2006, 53, 1; 179-188
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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