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    Wyświetlanie 1-3 z 3
    Tytuł:
    STAT activation and differential complex formation dictate selectivity of interferon responses
    Autorzy:
    Wesoly, Joanna
    Szweykowska-Kulinska, Zofia
    Bluyssen, Hans
    Powiązania:
    https://bibliotekanauki.pl/articles/1041103.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    transcription factor complexes
    gene regulation
    IRFs
    JAK/STAT pathway
    IFNs
    Opis:
    Interferons (IFNs) induce gene expression by phosphorylating latent transcription factors belonging to the signal transducer and activator of transcription (STAT) family, mediated by janus kinases (Jaks). STAT dimers directly activate genes containing the IFNγ activation site (GAS) DNA element, with different STAT proteins displaying slightly different intrinsic DNA binding specificities. The combinatorial association of STATs with the additional DNA binding adaptor protein interferon regulatory factor (IRF)9 expands the range of enhancer elements that can be targeted by the JAK-STAT pathway to interferon-stimulated response element (ISRE) and IRF response element (IRE). Based on the amino-acid sequence similarity within the IRF family and functional overlap with the STAT family, in this paper we hypothesize that other IRF members could serve as adapter proteins for the STATs during IFN responses to redirect them to subsets of ISRE, GAS and/or IRE-containing IFN-stimulated genes (ISGs). In addition, the fact that STAT2 homodimers are not capable of binding consensus GAS sites leaves the possibility for a novel type of DNA-binding site bound by STAT2 homodimers and potentially other STAT complexes.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 1; 27-38
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Signal transducer and activator of transcription STAT3 plays a major role in gp130-mediated acute phase protein gene activation.
    Autorzy:
    May, Petra
    Schniertshauer, Ute
    Gerhartz, Claudia
    Horn, Friedemann
    Heinrich, Peter
    Powiązania:
    https://bibliotekanauki.pl/articles/1043431.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    immediate early genes
    STAT transcription factors
    acute phase proteins
    gp130
    Opis:
    Interleukin-6 is a potent inducer of acute-phase response gene transcription. The intracellular signal transduction mechanisms by which this and other biological effects of the cytokine are achieved include activation of the JAK-STAT signaling pathway. More specifically, activation of the signal transducers and activators of transcription STAT1, 3, and 5 in response to IL-6 has been described. We examined the relative potency of these three STAT factors for the activation of acute-phase gene promoters in HepG2 cells in a reporter gene-based assay, where specific STAT factors could be activated via recombinant receptor constructs bearing different STAT-recruiting modules. These experiments indicate that amongst the STAT factors known to be activated by IL-6 STAT3 is the most potent activator of acute-phase gene transcription.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 3; 595-601
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nuclear localization and binding affinity of STAT5b for the α2-macroglobulin gene promoter during rat liver development and the acute-phase response
    Autorzy:
    Mihailović, Mirjana
    Dinić, Svetlana
    Bogojević, Desanka
    Ivanović-Matić, Svetlana
    Uskoković, Aleksandra
    Arambašić, Jelena
    Grigorov, Ilijana
    Grdović, Nevena
    Vidaković, Melita
    Martinović, Vesna
    Petrović, Miodrag
    Poznanović, Goran
    Powiązania:
    https://bibliotekanauki.pl/articles/1041082.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    rat liver development
    phosphorylation
    nuclear extract
    nuclear matrix
    STAT5b
    α2-macroglobulin
    Opis:
    Expression of the rat α2-macroglobulin (MG) gene undergoes dynamic changes throughout an individual's life and during the acute-phase (AP) response. Details of the participation of the STAT family of transcription factors in its control remain incompletely understood. Here we examined the involvement of STAT5b in MG gene expression during development and the AP response. Immuno-blot analysis revealed the highest nuclear level of STAT5b in the fetus and during postnatal development, whereas in the adult it decreased. Stimulation of MG expression during the AP response was accompanied by a decrease in STAT5b. Examination of STAT5b localization revealed that the relative concentrations of STAT5b were higher in the nuclear matrix than in the nuclear extract. Affinity chromatography with the extended promoter region of the MG gene (-825/+12), followed by immuno-blot analysis, revealed dynamic changes in STAT5b binding. The highest concentration of the promoter-binding form of STAT5b was observed in the fetus. As postnatal development progressed, the level of promoter-bound STAT5b decreased and in the adult liver it was the lowest. Stimulation of MG gene expression during the AP response in both the fetus and adult was accompanied by significantly decreased STAT5b binding to the MG promoter. The AP response was accompanied by lower levels of STAT5b serine and tyrosine phosphorylation in both fetus and adult. In the nuclear matrix derived from adult tissues, tyrosine phosphorylated species were completely absent. We conclude that developmental-stage differences in the mechanisms that determine STAT5b nuclear localization contribute to its activity in vivo.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 2; 331-340
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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