Autor: Wójcik, Agnieszka - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Lclet 4 enhances pro-apoptotic and anti-invasive effects of mitoxantrone on human prostate cancer cells - in vitro study
Autorzy:: Koczurkiewicz, Paulina
Podolak, Irma
Wójcik, Katarzyna
Galanty, Agnieszka
Madeja, Zbigniew
Michalik, Marta
Czyż, Jarosław
Powiązania:: https://bibliotekanauki.pl/articles/1039527.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: triterpene saponosides (Lclet 4); mitoxantrone; combined therapy; prostate cancer; apoptosis; invasiveness.
Opis:: Triterpene saponosides are widely distributed plant secondary metabolites characterized by relatively low systemic cytotoxicity and a range of biological activities. These include anti-inflammatory, antimicrobial, vasoprotective and antitumor properties. In particular, the ability of saponins to enhance the cytotoxicity of chemotherapeutic drugs opened perspectives for their application in combined cancer chemotherapy. Here, we used human prostate cancer DU-145 cells as an in vitro model to elucidate the synergy of the interactions between biological activities of an oleanane type 13β,28-epoxy triterpene saponoside (Lclet 4) and mitoxantrone, which is a cytostatic drug commonly used in prostate cancer therapy. No cytotoxic or pro-apoptotic effect of Lclet 4 and mitoxantrone administered at the concentrations between 0.05 and 0.1 µg/ml could be seen. In contrast, cocktails of these agents exerted synergistic pro-apoptotic effects, accompanied by the activation of the caspase 3/7 system. This effect was paralleled by attenuating effects of Lclet 4/mitoxantrone cocktails on the invasive potential, metalloproteinase expression and motility of DU-145 cells. Multifaceted and additive effects of Lclet 4 and mitoxantrone on basic cellular traits crucial for prostate cancer progression indicate that the combined application of both agents at systemically neutral concentrations may provide the basis for new promising strategies of prostate cancer chemotherapy.
Źródło:: Acta Biochimica Polonica; 2013, 60, 3; 331-338
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Multidirectional effects of triterpene saponins on cancer cells - mini-review of in vitro studies
Autorzy:: Koczurkiewicz, Paulina
Czyż, Jarosław
Podolak, Irma
Wójcik, Katarzyna
Galanty, Agnieszka
Janeczko, Zbigniew
Michalik, Marta
Powiązania:: https://bibliotekanauki.pl/articles/1038965.pdf
Data publikacji:: 2015
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: triterpene saponins
cancer cells
invasiveness
apoptosis
proliferation
Opis:: Triterpene saponins (saponosides) are found in a variety of higher plants and display a wide range of pharmacological activities, including expectorant, anti-inflamatory, vasoprotective, gastroprotective and antimicrobial properties. Recently, a potential anticancer activity of saponins has been suggested by their cytotoxic, cytostatic, pro-apoptotic and anti-invasive effects. At high concentrations (more than 100 µM) saponins exert cytotoxic and haemolytic effects via permeabilization of the cell membranes. Noteworthy, the inhibition of cancer cell proliferation, the induction of apoptosis and attenuation of cell invasiveness is observed in the presence of low saponin concentrations. Saponins might affect the expression of genes associated with malignancy. These alterations are directly related to the invasive phenotype of cancer cells and depend on "cellular context". It illustrates the relationships between the action of saponins, and the momentary genomic/proteomic status of cancer cells. Here, we discuss the hallmarks of anti-cancer activity of saponins with the particular emphasis on anti-invasive effect of diverse groups of saponins that have been investigated in relation to tumor therapy.
Źródło:: Acta Biochimica Polonica; 2015, 62, 3; 383-393
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Differentiation of polyvalent bacteriophages specific to uropathogenic Proteus mirabilis strains based on the host range pattern and RFLP
Autorzy:: Maszewska, Agnieszka
Wójcik, Ewelina
Ciurzyńska, Aneta
Wojtasik, Arkadiusz
Piątkowska, Iwona
Dastych, Jarosław
Różalski, Antoni
Powiązania:: https://bibliotekanauki.pl/articles/1038818.pdf
Data publikacji:: 2016
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: P. mirabilis
UTI
bacteriophage
phage typing
RFLP
Opis:: Urinary tract infections (UTIs) caused by P. mirabilis are difficult to cure because of the increasing antimicrobial resistance of these bacteria. Phage therapy is proposed as an alternative infection treatment. The aim of this study was to isolate and differentiate uropathogenic P. mirabilis strain specific polyvalent bacteriophages producing polysaccharide depolymerases (PDs). 51 specific phages were obtained. The plaques of 29 bacteriophages were surrounded by halos, which indicated that they produced PDs. The host range analysis showed that, except phages 58B and 58C, the phage host range profiles differed from each other. Phages 35 and 45 infected all P. mirabilis strains tested. Another 10 phages lysed more than 90% of isolates. Among these phages, 65A, 70, 66 and 66A caused a complete lysis of the bacterial lawn formed by 62% to 78% of strains. Additionally, phages 39A and 70 probably produced PDs. The phages' DNA restriction fragment length polymorphism (RFLP) analysis demonstrated that genomes of 51 isolated phages represented 34 different restriction profiles. DNA of phage 58A seemed to be resistant to selected EcoRV endonuclease. The 33 RFLP-EcoRV profiles showed a Dice similarity index of 38.8%. 22 RFLP patterns were obtained from single phage isolates. The remaining 12 restriction profiles consisted of 2 to 4 viruses. The results obtained from phage characterization based on the pattern of phage host range in combination with the RFLP method enabled effective differentiation of the studied phages and selection of PD producing polyvalent phages for further study.
Źródło:: Acta Biochimica Polonica; 2016, 63, 2; 303-310
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Synthesis, biochemical and biological studies on oligonucleotides bearinga lipophilic dimethoxytrityl group
Autorzy:: Misiura, Konrad
Wójcik, Marzena
Krakowiak, Agnieszka
Koziołkiewicz, Maria
Pawłowska, Zofia
Pluskota, Elżbieta
Cierniewski, Czesław
Stec, Wojciech
Powiązania:: https://bibliotekanauki.pl/articles/1044849.pdf
Data publikacji:: 1998
Wydawca:: Polskie Towarzystwo Biochemiczne
Źródło:: Acta Biochimica Polonica; 1998, 45, 1; 27-32
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Light conditions alter accumulation of long chain polyprenols in leaves of trees and shrubs throughout the vegetation season.
Autorzy:: Bajda, Agnieszka
Chojnacki, Tadeusz
Hertel, Józefina
Swiezewska, Ewa
Wójcik, Jacek
Kaczkowska, Alicja
Marczewski, Andrzej
Bojarczuk, Tomasz
Karolewski, Piotr
Oleksyn, Jacek
Powiązania:: https://bibliotekanauki.pl/articles/1041482.pdf
Data publikacji:: 2005
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: plant polyprenols
SLA
Opis:: In many plants belonging to angiosperms and gymnosperms the accumulation in leaves of long chain polyprenols and polyprenyl esters during growth in natural habitats depends on the light intensity. The amount of polyprenols in leaves is also positively correlated with the thickness of the leaf blade (SLA, specific leaf area). The polyprenol content of leaves shows seasonal changes with a maximum in autumn and a minimum in early summer with the difference between poorly and well illuminated plants persisting throughout the vegetation season.
Źródło:: Acta Biochimica Polonica; 2005, 52, 1; 233-241
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki