Autor: Mirosław, Jerzy - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: The influence of chosen physico-chemical factors on proteolytic activity of the hatching liquid of Coregonus albula and C. lavaretus
Autorzy:: Luberda, Zofia
Strzeżek, Jerzy
Łuczyński, Mirosław
Powiązania:: https://bibliotekanauki.pl/articles/1045594.pdf
Data publikacji:: 1992
Wydawca:: Polskie Towarzystwo Biochemiczne
Źródło:: Acta Biochimica Polonica; 1992, 39, 1; 59-64
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: The influence of metal ions and some inhibitors on the activity of the proteinase isolated from the hatching liquid of Coregonus peled
Autorzy:: Luberda, Zofia
Strzeżek, Jerzy
Luczyński, Mirosław
Powiązania:: https://bibliotekanauki.pl/articles/1045817.pdf
Data publikacji:: 1990
Wydawca:: Polskie Towarzystwo Biochemiczne
Źródło:: Acta Biochimica Polonica; 1990, 37, 1; 197-200
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: The alcohol dehydrogenase isoenzyme (ADH IV) as a candidate tumour marker of esophageal cancer
Autorzy:: Jelski, Wojciech
Laniewska-Dunaj, Magdalena
Niklinski, Jacek
Kozłowski, Miroslaw
Laudanski, Jerzy
Szmitkowski, Maciej
Powiązania:: https://bibliotekanauki.pl/articles/1039560.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: alcohol dehydrogenase isoenzymes
esophageal cancer
Opis:: Objective: Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are present in esophageal cancer cells. Moreover the total activity of ADH as well as the activity of class IV ADH isoenzyme is significantly higher in cancer tissue than in healthy mucosa. The activity of these enzymes in cancer cells is reflected in the sera and could thus be helpful for diagnostics of esophageal cancer. The aim of this study was to investigate a potential significance of ADH isoenzymes and ALDH as tumour markers of esophageal cancer. We defined diagnostic sensitivity, specificity, predictive value for positive and negative results, and receiver-operating characteristics (ROC) curve for tested enzymes. Methods: Serum samples were taken for routine biochemical investigation from 180 patients with esophageal cancer before treatment. Total ADH activity was measured by a photometric method with p-nitrosodimethylaniline as a substrate and ALDH activity by a fluorometric method with 6-methoxy-2-naphtaldehyde as a substrate. For the measurement of the activity of class I and II isoenzymes we employed the fluorometric methods, with class-specific fluorogenic substrates. The activity of class III alcohol dehydrogenase was measured by a photometric method with formaldehyde and class IV with m-nitrobenzaldehyde as a substrate. Results: There was a significant increase in the activity of class IV of ADH isoenzyme (7.65 mU/l vs 5.88 mU/l) and total ADH activity (1198 mU/l vs 848 mU/l) in the sera of esophageal cancer patients compared to the control. The diagnostic sensitivity for ADH IV was 72%, the specificity 76%, the positive and negative predictive values were 80% and 72% respectively. The area under the ROC curve for ADH IV was 0.65. Conclusion: The results suggest a potential significance of ADH IV as a marker of esophageal cancer.
Źródło:: Acta Biochimica Polonica; 2013, 60, 3; 489-493
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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