- Tytuł:
- In vitro release of cytotoxic nucleoside analogs from lactide-caprolactone and lactide-glycolide copolymers.
- Autorzy:
-
Kryczka, Tomasz
Bero, Maciej
Kasperczyk, Janusz
Dobrzyński, Piotr
Marciniec, Barbara
Popierzal-Brzezińska, Maria
Grieb, Paweł - Powiązania:
- https://bibliotekanauki.pl/articles/1043828.pdf
- Data publikacji:
- 2002
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
sterilization
cladribine
5-fluorouracil
biodegradable copolymers - Opis:
- The aims of our study were to assess the release of cytotoxic nucleoside analogs 5-fluorouracil and 2-chloro-2'-deoxyadenosine from different lactide-glycolide or lactide-caprolactone biodegradable copolymers and the effects of sterilization on this release. The polymers were sterilized either with ethylene oxide at 37°C, or with gamma radiation (15 kGy, 20 kGy, or 25 kGy). The kinetics of nucleoside release from the copolymers were measured over 50 days. Four copolymers exhibited relatively constant release of nucleosides in micromolar concentrations during the entire observation period. Sterilization with either ethylene oxide or gamma radiation only slightly influenced nucleoside release. Further development of these copolymers as an intracerebral nucleoside delivery system for local treatment of brain tumors is indicated.
- Źródło:
-
Acta Biochimica Polonica; 2002, 49, 1; 205-210
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł