- Tytuł:
- Activity of lysosomal exoglycosidases in submandibular glands of rats intoxicated by cadmium at doses related to human chronic environmental and occupational exposures.
- Autorzy:
-
Zalewska, Anna
Brzó;ska, Małgorzata
Marciniak, Justyna
Karaszewska, Katarzyna
Zwierz, Krzysztof
Moniuszko-Jakoniuk, Janina - Powiązania:
- https://bibliotekanauki.pl/articles/1041566.pdf
- Data publikacji:
- 2004
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
exoglycosidases
β-galactosidase
α-mannosidase
cadmium
salivary glands of rats
β-N-acetylhexosaminidase - Opis:
- Work in cadmium (Cd) smelter and smoking cigarettes damages teeth and oral mucosa which are protected by tissue and salivary glycoconjugates: glycoproteins, glycolipids, and proteoglycans. We worked out a rat model imitating human "environmental" and "occupational" exposure to cadmium using 5 mg Cd and 50 mg Cd/l in drinking water, respectively. In submandibulary glands of exposed to Cd rats, we found the time and dose dependent accumulation of Cd and simultanous decrease in activity of β-N-acetylhexosaminidase (HEX). In homogenates of submandibulary glands of control rats, β-N-acetylhexosaminidase showed the highest activity. The activities of α;-mannosidase and β-galactosidase were very low. None of these exoglycosidases were inhibited by Cd even at 44 mM concentration.
- Źródło:
-
Acta Biochimica Polonica; 2004, 51, 3; 831-837
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł