- Tytuł:
- Effect of substrate stiffness on differentiation of umbilical cord stem cells
- Autorzy:
-
Witkowska-Zimny, Małgorzata
Walenko, Katarzyna
Wałkiewicz, Anna
Pojda, Zygmunt
Przybylski, Jacek
Lewandowska-Szumieł, Małgorzata - Powiązania:
- https://bibliotekanauki.pl/articles/1039745.pdf
- Data publikacji:
- 2012
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
substrate stiffness
osteogenic differentiation
umbilical cord mesenchymal stromal/stem cells - Opis:
- Tissue formation and maintenance is regulated by various factors, including biological, physiological and physical signals transmitted between cells as well as originating from cell-substrate interactions. In our study, the osteogenic potential of mesenchymal stromal/stem cells isolated from umbilical cord Wharton's jelly (UC-MSCs) was investigated in relation to the substrate rigidity on polyacrylamide hydrogel (PAAM). Osteogenic differentiation of UC-MSCs was enhanced on stiff substrate compared to soft substrates, illustrating that the mechanical environment can play a role in differentiation of this type of cells. These results show that substrate stiffness can regulate UC-MSCs differentiation, and hence may have significant implications for design of biomaterials with appropriate mechanical properties for regenerative medicine.
- Źródło:
-
Acta Biochimica Polonica; 2012, 59, 2; 261-264
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł