Autor: Li, Long - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Molecular cloning and expression analysis of a new gene for short-chain dehydrogenase/reductase 9
Autorzy:: Liu, Shen
Huang, Chaoqun
Li, Dawei
Ren, Weihua
Zhang, Haoxing
Qi, Meiyan
Li, Xin
Yu, Long
Powiązania:: https://bibliotekanauki.pl/articles/1041143.pdf
Data publikacji:: 2007
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: liver
clone
short-chain dehydrogenase/reductase
Opis:: We report here the cloning and characterization of a novel human short-chain dehydrogenases/reductase gene SCDR9, isolated from a human liver cDNA library, and mapped to 4q22.1 by browsing the UCSC genomic database. SCDR9 containing an ORF with a length of 900 bp, encoding a protein with a signal peptide sequence and an adh_short domain. GFP localization shows SCDR9 protein concentrated in some site of the cytoplasm, but not in the ER. Expression pattern in eighteen tissues revealed that SCDR9 is expressed highly in liver. Soluble recombinant protein was successfully purified from Escherichia coli using pET28A(+) expression vector. Our data provides important information for further study of the function of the SCDR9 gene and its products.
Źródło:: Acta Biochimica Polonica; 2007, 54, 1; 213-218
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 2.

Tytuł:: Overexpression of human CUTA isoform2 enhances the cytotoxicity of copper to HeLa cells
Autorzy:: Yang, Jingchun
Li, Qiang
Yang, Huirong
Yan, Lichong
Yang, Liu
Yu, Long
Powiązania:: https://bibliotekanauki.pl/articles/1040764.pdf
Data publikacji:: 2008
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: copper toxicity
CUTA isoform2
overexpression
copper-induced apoptosis
cell proliferation
Opis:: Copper, an essential transient element, can be toxic to cells when present in excess. Altered copper homeostasis is involved in pathological events of many diseases. Human CUTA isoform2 is a member of cation tolerance protein (CutA1) family. In this study, we examined the effect of CUTA isoform2 overexpression on copper toxicity. It was shown that overexpressed CUTA isoform2 sensitized HeLa cells to copper toxicity by promoting copper-induced apoptosis. The inhibition effect of excessive copper on cell proliferation was also enhanced by overexpressed CUTA isoform2. So CUTA isoform2 was implicated to be involved in the cytotoxicity of copper.
Źródło:: Acta Biochimica Polonica; 2008, 55, 2; 411-415
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

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