Autor: Król, Andrzej - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Molecular characterization and symbiotic importance of prsD gene of Rhizobium leguminosarum bv. trifolii TA1
Autorzy:: Mazur, Andrzej
Wielbo, Jerzy
Król, Jarosław
Kopcińska, Joanna
Łotocka, Barbara
Golinowski, Władysław
Skorupska, Anna
Powiązania:: https://bibliotekanauki.pl/articles/1044765.pdf
Data publikacji:: 1998
Wydawca:: Polskie Towarzystwo Biochemiczne
Źródło:: Acta Biochimica Polonica; 1998, 45, 4; 1067-1073
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 2.

Tytuł:: Acute hepatologic and nephrologic effects of calcitriol in Syrian golden hamster (Mesocricetus auratus)
Autorzy:: Podgorska, Ewa
Sniegocka, Martyna
Mycinska, Marianna
Trybus, Wojciech
Trybus, Ewa
Kopacz-Bednarska, Anna
Wiechec, Olga
Krzykawska-Serda, Martyna
Elas, Martyna
Krol, Teodora
Urbanska, Krystyna
Slominski, Andrzej
Powiązania:: https://bibliotekanauki.pl/articles/1038358.pdf
Data publikacji:: 2018
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: calcitriol
Syrian golden hamster
hepatologic toxicity
nephrologic toxicity
Opis:: Although vitamin D is included in the group of fat-soluble vitamins, it must be considered as a prohormone. Its active forms, including calcitriol, have pleiotropic effects and play an important role in the regulation of cell proliferation, differentiation and apoptosis, as well as in hormone secretion, and they demonstrate anti-cancer properties. Since calcitriol delivery can be beneficial for the organism, and Syrian golden hamsters represent a unique experimental model, we decided to investigate its toxicity in this species. In this study, we injected calcitriol intraperitoneally at doses 0 (control), 0.180±0.009 µg/kg and 0.717±0.032 µg/kg. Animal behavior was observed for 72 hrs after injection, and afterwards blood, liver and kidneys were collected for post-mortem examination, electron microscopy, and hematology analyses. The highest dose of calcitriol induced a change in animal behavior from calm to aggressive, and the liver surface showed morphological signs of damage. Following injection of calcitriol, ultrastructural changes were also observed in the liver and kidneys, e.g. vacuolization and increased number of mitochondria. There was also a trend for increased serum levels of aspartate aminotransferase (AST), but not of alanine aminotransferase (ALT) or GGTP (gamma-glutamyl transpeptidase). There was no change in Ca, Mg and P levels, as well as in blood morphology between experimental and control groups. These results indicate that calcitriol at 0.717, but not at 0.180 µg/kg, may induce acute damage to the liver and kidneys, without inducing calcemia. We propose that the hepatotoxic effect of calcitriol in hamster constitutes the primary cause of behavioral changes.
Źródło:: Acta Biochimica Polonica; 2018, 65, 3; 351-358
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Informacja

Wyszukujesz frazę "Król, Andrzej" wg kryterium: Autor

Źródło danych

Dostawca treści

Kolekcja

Rok wydania

Wydawca

Temat

Autor

Typ dokumentu

Język