Autor: Jawien, Arkadiusz - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Background level of 8-oxo-2-deoxyguanosine in lymphocyte DNA does not correlate with the concentration of antioxidant vitamins in blood plasma.
Autorzy:: Gackowski, Daniel
Ciecierski, Marek
Jawień, Arkadiusz
Oliński, Ryszard
Powiązania:: https://bibliotekanauki.pl/articles/1044149.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: α-tocopherol
ascorbic acid
retinol
8-oxo-2'-deoxyguanosine
Opis:: Antioxidant vitamins, being effective free radical scavengers, can protect cellular DNA from oxidative damage. Therefore, in the present study we report on the relationship between basal level of 8-oxo-2'-deoxyguanosine in human lymphocyte DNA and the concentration of antioxidant vitamins (A, C and E). The average level of 8-oxo-2'-deoxyguanosine in lymphocytes of the studied group (15 males and 20 females) was 9.57 per 106 dG molecules. The endogenous level of ascorbic acid (vitamin C) in the plasma was, on average, 56.78 μM, while the mean concentrations of retinol (vitamin A) and α-tocopherol (vitamin E) were 1.24 μM and 25.74 μM, respectively. No correlations were found between individual 8-oxo-2'-deoxyguanosine levels in lymphocyte DNA and endogenous concentration of the vitamins.
Źródło:: Acta Biochimica Polonica; 2001, 48, 2; 535-539
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 2.

Tytuł:: Lymphocyte labile iron pool, plasma iron, transferrin saturation and ferritin levels in colon cancer patients.
Autorzy:: Gackowski, Daniel
Kruszewski, Marcin
Banaszkiewicz, Zbigniew
Jawien, Arkadiusz
Olinski, Ryszard
Powiązania:: https://bibliotekanauki.pl/articles/1043840.pdf
Data publikacji:: 2002
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: labile iron pool
iron metabolism
colon cancer
Opis:: Patients with colorectal carcinoma showed statistically significant lower values of transferrin saturation, total iron binding capacity and serum iron level as compared with control group, while the level of ferritin and the size of labile iron pool in carcinoma patients were higher, although this difference was not statistically significant. Our observations are in favour of the hypothesis which suggests that changes in iron metabolism restrict iron availability for tumour cells and as consequence, slow their growth.
Źródło:: Acta Biochimica Polonica; 2002, 49, 1; 269-273
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 3.

Tytuł:: Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer
Autorzy:: Linkowska, Katarzyna
Jawień, Arkadiusz
Marszałek, Andrzej
Skonieczna, Katarzyna
Grzybowski, Tomasz
Powiązania:: https://bibliotekanauki.pl/articles/1039019.pdf
Data publikacji:: 2015
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: POLG gene
CAG repeat
colorectal cancer
somatic mutations
Opis:: Mitochondrial DNA polymerase gamma (POLG) is the only DNA polymerase involved in maintaining the mitochondrial genome. Recent studies demonstrated an association of CAG repeat polymorphism in the second exon of POLG gene with the risk of cancer. We investigated the CAG repeat variability in the POLG gene in tumor and non-tumor tissues from colorectal cancer patients and in DNA samples isolated from blood obtained from age-matched healthy persons. Somatically occuring CAG-repeat alterations in cancer tissues have been observed in 10% of patients, but no association has been found between the CAG repeat variants in the POLG gene and colorectal cancer risk.
Źródło:: Acta Biochimica Polonica; 2015, 62, 3; 625-627
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

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