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    Wyświetlanie 1-4 z 4
    Tytuł:
    Pinellia ternata agglutinin produced in Bombyx mori cells exhibits bioactivity
    Autorzy:
    Xu, Tao
    Wang, Bo
    Wang, Liya
    Zhang, Yaozhou
    Lv, Zhengbing
    Powiązania:
    https://bibliotekanauki.pl/articles/1039738.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Pinellia ternata agglutinin
    silkworm bioreactor
    plant lectin
    Bombyx mori cells
    Opis:
    Pinellia ternata agglutinin (PTA) is highly homologous to many other monocot mannose-binding lectins which reportedly possess antitumor activities. Its production in silkworm cells has great application potential because the baculovirus expression system can produce post-translationally modified proteins at low cost. In the current study, the pta gene was cloned and expressed in silkworm cells, and the expressed protein was analyzed using a hemagglutination assay. A preliminary in vitro study on its anti-proliferative activity was performed. The results show that the recombinant PTA with an apparent molecular mass of 29 kDa can hemagglutinate rabbit erythrocytes and this activity can be inhibited by D-mannan at a low concentration. In addition, the recombinant hemagglutinin exhibited a dose-dependent anti-proliferative activity on hepatoma cells. The results of the current study suggest that PTA and other important bioactive proteins could be produced by silkworm bioreactor for biomedicine research and application.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 2; 231-236
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Gastrodin ameliorates spinal cord injury via antioxidant and anti-inflammatory effects
    Autorzy:
    Du, Fangtao
    Wang, Xiaoning
    Shang, Bo
    Fang, Jifeng
    Xi, Yuting
    Li, Aijuan
    Diao, Yenze
    Powiązania:
    https://bibliotekanauki.pl/articles/1038788.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    spinal cord injury
    gastrodin
    inflammation
    oxidative stress
    Nrf2
    Opis:
    Spinal cord injury (SCI) is one of the most severe traumatic injuries that results in dysfunction of limbs and trunk below the damaged section. Recent studies have shown that gastrodin (GAS) could improve the recovery of SCI. In the current study, we aimed to examine the possible mechanism underlying the effect of GAS on recovery of SCI in rats. In rats with SCI, GAS improved locomotor functions and decreased permeability of blood-spinal cord barrier, as illustrated by increase of Basso-Beattie-Bresnahan scores and decrease of Evans blue leakage. In addition, GAS inhibited inflammation, as evidenced by decrease of proinflammatory cytokines, including tumor necrosis factor α (TNFα) and interleukin-1β (IL-1β) in rats following SCI. Moreover, increase of TBARS content and decrease of glutathione (GSH) content and superoxide dismutase (SOD) activities in SCI rats were inhibited by GAS. Furthermore, GAS enhanced mRNA expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), catalytic subunit of γ-glutamylcysteine ligase (GCLc) and modified subunit of γ-glutamylcysteine ligase (GCLm). The data suggested that GAS may promote the recovery of SCI through the enhancement of Nrf2-GCLc/GCLm signaling pathway, and subsequent improvement of oxidative stress and inflammation, resulting in decrease of permeability of BSCB and improved recovery of locomotor function in rats with SCI. The results have provided novel insights into GAS-related therapy of SCI and associated neurodegenerative diseases.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 3; 589-593
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biochemical characterization of a catalase from Vibrio vulnificus, a pathogen that causes gastroenteritis
    Autorzy:
    Pei, Jihua
    Wang, Haijun
    Wu, Limin
    Xia, Shenglong
    Xu, Changlong
    Zheng, Bo
    Li, Tianya
    Jiang, Yi
    Powiązania:
    https://bibliotekanauki.pl/articles/1038620.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    catalase
    Vibrio vulnificus
    kinetics
    mutation
    gastroenteritis.
    Opis:
    Vibrio vulnificus is a virulent human pathogen causing gastroenteritis and possibly life threatening septicemia in patients. Most V. vulnificus are catalase positive and can deactivate peroxides, thus allowing them to survive within the host. In the study presented here, a catalase from V. vulnificus (CAT-Vv) was purified to homogeneity after expression in Escherichia coli. The kinetics and function of CAT-Vv were examined. CAT-Vv catalyzed the reduction of H2O2 at an optimal pH of 7.5 and temperature of 35°C. The Vmax and Km values were 65.8±1.2 U/mg and 10.5±0.7 mM for H2O2, respectively. Mutational analysis suggests that amino acids involved in heme binding play a key role in the catalysis. Quantitative reverse transcription-PCR revealed that in V. vulnificus, transcription of CAT-Vv was upregulated by low salinity, heat, and oxidative stresses. This research gives new clues to help inhibit the growth of, and infection by V. vulnificus.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 3; 543-549
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Newly identified transcripts of UL4 and UL5 genes of human cytomegalovirus
    Autorzy:
    Gao, Shuang
    Ruan, Shan
    Ma, Yanping
    Li, Mali
    Wang, Lin
    Zheng, Bo
    Qi, Ying
    Sun, Zhengrong
    Huang, Yujing
    Ruan, Qiang
    Powiązania:
    https://bibliotekanauki.pl/articles/1039141.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    HCMV
    UL4
    UL5
    transcript
    Opis:
    Human cytomegalovirus (HCMV) UL4 and UL5 genes are two members of the RL11 gene family. In an earlier study, three UL4 transcripts of about 1.7, 1.5 and 1.4 kb were found in early and late classes after infection by the Towne strain by nuclease protection and primer extension analyses. In the present study, two UL4 transcripts (1.5 and 1.7 kb) were found by cDNA library screening, Northern blot, 3' and 5' RACE analyses to appear initially in the immediate early phase and one UL4 transcript (1.4 kb) in the late phase in a low-passage clinical isolate. Furthermore, two novel low-abundance UL5 transcripts with the same 3' terminus as the identified UL4 transcripts in the UL4-UL5 gene region were found in late class RNAs.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 1; 97-101
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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