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Wyszukujesz frazę "Bielawska, Anna" wg kryterium: Autor

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    Wyświetlanie 1-4 z 4
    Tytuł:
    Inhibitory effects of pentamidine analogues on protein biosynthesis in vitro.
    Autorzy:
    Bielawski, Krzysztof
    Galicka, Anna
    Bielawska, Anna
    Średzińska, Krystyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1044401.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    amidine
    elongation factors
    protein synthesis in vitro
    DAPI
    Opis:
    Pentamidine despite its rather high toxicity, is currently in clinical use. For development of new drugs of this type it is important to know the mechanism of their action. Two new amidines (I and II) and 4',6-diamidino-2-phenylindole (DAPI) were found in preliminary experiments to inhibit protein synthesis in vitro in the cell-free rat liver system. The three compounds differed in the precise mode of action. The inhibitory effect of I on the activity of the eukaryotic elongation factor eEF-2 and ribosomes seems to suggest that the binding site of eEF-2 on the ribosome was blocked by this compound. eEF-2 has been identified as the primary target of II and eEF-1 as the primary target of DAPI in the system studied.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 1; 113-120
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d(CGCGAATTCGCG)2.
    Autorzy:
    Bielawski, Krzysztof
    Bielawska, Anna
    Bartulewicz, Danuta
    Różański, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/1044344.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    carbocyclic analogues of netropsin and distamycin
    distamycin
    DNA-ligand interaction
    netropsin
    molecular modelling
    Opis:
    A molecular mechanics and molecular dynamics approach was used to examine the structure of complexes formed between the d(CGCGAATTCGCG)2 duplex and netropsin, distamycin, and four carbocyclic analogues of netropsin and distamycin (1-4). The resulting structures of the ligand-DNA model complexes and their energetics were examined. It is predicted that the compounds 1-4 should have a decreased affinity for the minor groove of AT-rich regions in comparison to netropsin and distamycin. From the energetic analysis it appears that van der Waals and electrostatic interactions are more important than specific hydrogen bonds in stabilizing the ligand-duplex complexes. We predict that compounds 1 and 2 are effectively isohelical with the DNA minor groove. The superior DNA-binding afforded by 1 and 2 in comparison to 3 and 4 results from their more effective penetration into the minor groove and smaller perturbation of molecular structure upon complex formation.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 3; 855-866
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    New carbocyclic analogues of netropsin: Synthesis and inhibition of topoisomerases.
    Autorzy:
    Pućkowska, Anna
    Bielawski, Krzysztof
    Bielawska, Anna
    Róański, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/1043824.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    topoisomerase inhibition
    DNA interaction
    lexitropsin
    carbocyclic analogues of netropsin
    Opis:
    A series of carbocyclic analogues of netropsin were synthesized and evaluated for their capacity to inhibit human topoisomerases I and II in vitro. The compounds are oligopeptides containing 1,4-di- and 1,2,5-trisubstituted benzene rings and unsubstituted N-terminal NH2 groups. Compounds 4-7 consist of two netropsin-like units linked by aliphatic (tetra- and hexamethylene) chains. In the topoisomerase I and II assay, the relaxation of pBR322 plasmid was inhibited by compounds 4-7 at 100 μM concentration.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 1; 177-183
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Diversity of influenza-like illness etiology in Polish Armed Forces in influenza epidemic season
    Autorzy:
    Kocik, Janusz
    Niemcewicz, Marcin
    Winnicka, Izabela
    Michalski, Aleksander
    Bielawska-Drózd, Agata
    Kołodziej, Marcin
    Joniec, Justyna
    Cieślik, Piotr
    Graniak, Grzegorz
    Mirski, Tomasz
    Gaweł, Jerzy
    Bielecka-Oder, Anna
    Kubiak, Leszek
    Russell, Kevin
    Powiązania:
    https://bibliotekanauki.pl/articles/1039252.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Influenza
    ILI
    surveillance
    Polish Army
    Opis:
    The aim of this study was to conduct an epidemiological and laboratory surveillance of Influenza-Like Illnesses (ILI) in Polish Armed Forces, civilian military personnel and their families in 2011/2012 epidemic season, under the United States Department of Defense-Global Emerging Infections Surveillance and Response System (DoD-GEIS). ILI incidence data were analyzed in relation to age, gender, patient category as well as pathogen patterns. Multiple viral, bacterial and viral-bacterial co-infections were identified. Nose and throat swabs of active duty soldiers in the homeland country and in the NATO peacekeeping forces KFOR (Kosovo Force), as well as members of their families were tested for the presence of viral and bacterial pathogens. From October 2011 to May 2012, 416 specimens from ILI symptoms patients were collected and analyzed for the presence of viral and bacterial pathogens. Among viruses, coronavirus was the most commonly detected. In the case of bacterial infections, the most common pathogen was Staphylococcus aureus.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 3; 489-494
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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