- Tytuł:
- Poly(acrylic acid-co-methyl methacrylate)/metronidazole systems: synthesis and complexation
- Autorzy:
-
Bialik-Wąs, Katarzyna
Pielichowski, Krzysztof - Powiązania:
- https://bibliotekanauki.pl/articles/1039502.pdf
- Data publikacji:
- 2013
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
metronidazole
poly(AA-co-MMA)
drug delivery systems - Opis:
- We report on preparation of poly(acrylic acid-co-methyl methacrylate) (PAM) micro- and nanoparticles and, in the subsequent stage, complexation reaction with the active substance - metronidazole (MET). The drug release behavior of MET - loaded PAM micro- and nanoparticles was evaluated in water and phosphate buffered saline (PBS, 0.9% NaCl) at 37ºC. It has been found that introduction of MET into PAM micro- and nanoparticles enabled gradual and controlled release of the active substance. Structural analysis using FT-IR (ATR) and 1H NMR, as well as surface morphology assessment by SEM, were performed.
- Źródło:
-
Acta Biochimica Polonica; 2013, 60, 4; 835-838
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł