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    Wyświetlanie 1-6 z 6
    Tytuł:
    Synthesis, biochemical and biological studies on oligonucleotides bearinga lipophilic dimethoxytrityl group
    Autorzy:
    Misiura, Konrad
    Wójcik, Marzena
    Krakowiak, Agnieszka
    Koziołkiewicz, Maria
    Pawłowska, Zofia
    Pluskota, Elżbieta
    Cierniewski, Czesław
    Stec, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/1044849.pdf
    Data publikacji:
    1998
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Źródło:
    Acta Biochimica Polonica; 1998, 45, 1; 27-32
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Hepatic expression of miR-122 and antioxidant genes in patients with chronic hepatitis B
    Autorzy:
    Wójcik, Kamila
    Piekarska, Anna
    Szymańska, Bożena
    Jabłonowska, Elżbieta
    Powiązania:
    https://bibliotekanauki.pl/articles/1038774.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    hepatitis B
    antioxidant genes
    miR-122
    Opis:
    Introduction: The pathogenesis of chronic hepatitis B depends on both, the immune response and oxidative stress. Aim of the study: To assess the hepatic expression of miR-122 and the antioxidant genes: HMOX-1, NQO1 and GFER1, in liver biopsy specimens obtained from patients with chronic hepatitis B, with regard to selected clinical and histological parameters, using RT-PCR. Results: The study group comprised 34 HBV-infected patients. Statistically significant associations were found between lower hepatic expression of HMOX-1 and greater severity of liver inflammation (p=0.04). However, significantly higher expression of NQO1 was observed in patients with advanced liver fibrosis (p=0.035). Hepatic expression of miR-122 in HBV patients was not associated with viral load or liver injury. Conclusion: The hepatic expression of HMOX-1and NQO1 may be associated with liver injuries in chronic hepatitis B. However, hepatic expression of miR-122 does not seem to correspond to progression of the liver disease.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 3; 527-531
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Expression of RUNX2 and its signaling partners TCF7, FGFR1/2 in cleidocranial dysplasia
    Autorzy:
    Pawłowska, Elżbieta
    Wójcik, Katarzyna
    Synowiec, Ewelina
    Szczepańska, Joanna
    Błasiak, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1039147.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    RUNX2
    Wnt signaling
    TCF7
    fibroblast growth factor signaling
    FGFR1
    FGFR2
    Opis:
    RUNX2 is a member of the PEBP2/CBF transcription factors family controlling the expression of genes whose products are essential for bone formation. Mutations in the RUNX2 gene may be associated with cleidocranial dysplasia (CCD), a rare skeletal disease characterized by stature aberrations, delayed closure of the cranial sutures, hypoplastic or aplastic clavicles, and multiple dental abnormalities. As RUNX2 is involved in many signaling pathways, we hypothesize that CCD may be associated with their changes. We determined the expression of RUNX2 and its signaling partners TCF7, involved in canonical Wnt signaling, and fibroblast growth factor receptors, FGFR1 and FGFR2 in periodontum of CCD patients and control individuals. We did not observe any differences between the level of RUNX2, TCF7 and FGFR1/2 mRNA, determined by real-time PCR, in CDD patients and controls. Therefore, RUNX2 signaling pathways with their partners TCF7 and FGFR1/2 may not be involved in CCD pathogenesis.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 1; 123-126
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Inhibition of plasminogen activator inhibitor release in endothelial cell cultures by antisense oligodeoxyribonucleotides with a 5˘-end lipophilic modification
    Autorzy:
    Kobylańska, Anna
    Pluskota, Elżbieta
    Światkowska, Maria
    Wójcik, Marzena
    Cierniewska-Cieślak, Aleksandra
    Krakowiak, Agnieszka
    Boczkowska, Małgorzata
    Pawłowska, Zofia
    Okruszek, Andrzej
    Koziołkiewicz, Maria
    Cierniewski, Czesław
    Stec, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/1044478.pdf
    Data publikacji:
    1999
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Źródło:
    Acta Biochimica Polonica; 1999, 46, 3; 679-691
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sustained virologic response and IL28B single-nucleotide polymorphisms in patients with chronic hepatitis C treated with pegylated interferon alfa and ribavirin
    Autorzy:
    Jabłonowska, Elżbieta
    Piekarska, Anna
    Koślińska-Berkan, Ewa
    Omulecka, Aleksandra
    Szymańska, Bożena
    Wójcik, Kamila
    Powiązania:
    https://bibliotekanauki.pl/articles/1039705.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ribavirin
    interferon
    HCV
    IL28B
    HIV
    sustained virologic response
    Opis:
    Introduction. Hepatitis C virus (HCV) infection is a global health problem which can lead to liver cirrhosis or hepatocellular carcinoma in one-fifth of chronically infected patients. Materials and methods. The study group consisted of 123 patients: 90 with HCV mono- and 33 with HIV/HCV co-infection, who were treated with pegylated interferon alfa (Peg-IFN-α) and ribavirin. We analyzed selected pretreatment factors: age, sex, HIV/HCV co-infection, grade of inflammation, necrotic changes and fibrosis in histological analysis of liver bioptates, HCV viral load, HCV genotypes, and single nucleotide polymorphisms (SNPs) of IL28B and tried to find out which of them influence sustained virological response (SVR). The IL28B SNP C/T (rs12979860) was analyzed using Custom® SNP Genotyping Assays (Applied Biosystems). Results. Multivariate analysis demonstrated that after adjusting for the other variables three predictors independently influence SVR, namely genotype 3 of HCV, presence of the CC genotype and age >40 years (OR respectively 15.14, 3.62, and 0.36). HCV mono-infected patients were infected with HCV genotype 3 or 4 less frequently (p=0.0001) compared to HIV/HCV co-infected individuals. In patients with HIV/HCV co-infection the CC variant occurred more frequently whereas CT was found less frequently (p=0.001, p=0.0146, respectively). In patients with HIV/HCV co-infection, 3 and 4 genotype of HCV occurred more frequently compared to patients with HCV mono-infection (p=0.0001). Conclusions. These data suggest that age, HCV genotype and IL28B polymorphism are useful for prediction of the response to treatment with Peg-IFN-α and ribavirin. The more frequent occurrence of HCV genotypes 3 or 4 in patients with HIV/HCV co-infection could be associated with the route of transmission.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 3; 333-337
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pentoxifylline and its active metabolite lisofylline attenuate transforming growth factor β1-induced asthmatic bronchial fibroblast-to-myofibroblast transition
    Autorzy:
    Wójcik-Pszczoła, Katarzyna
    Hińcza, Kinga
    Wnuk, Dawid
    Kądziołka, Dominika
    Koczurkiewicz, Paulina
    Sanak, Marek
    Madeja, Zbigniew
    Pękala, Elżbieta
    Michalik, Marta
    Powiązania:
    https://bibliotekanauki.pl/articles/1038759.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    theophylline
    pentoxifylline
    lisofylline
    transforming growth factor type β
    fibroblast-to-myofibroblast transition
    asthma
    Opis:
    Bronchial asthma is characterized by persistent airway inflammation and airway wall remodeling. Among many different cells and growth factors triggering changes in bronchi structure, transforming growth factor β1-induced fibroblast to myofibroblast transition is believed to be very important. The aim of this study was to evaluate whether theophylline (used in asthma therapy) and two other methylxanthines (pentoxifylline and its active metabolite lisofylline), may affect transforming growth factor β1-induced fibroblast to myofibroblast transition in bronchial fibroblasts derived from asthmatic patients. We show here for the first time that selected methylxanthines effectively reduce transforming growth factor β1-induced myofibroblast formation in asthmatic bronchial fibroblast populations. PTX was found to be the most effective methylxanthine. The number of differentiated myofibroblasts after PTX, LSF and THEO administration was reduced at least twofold. Studies on the use of methylxanthines opens a new perspective in the development of novel strategies in asthma therapy through their two-pronged, anti-inflammatory and anti-fibrotic action. In the future they can be considered as promising anti-fibrotic drugs.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 3; 437-442
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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