- Tytuł:
- Development of a new, simple and cost-effective diagnostic tool for genetic screening of hereditary colorectal cancer - the DNA microarray assay
- Autorzy:
-
Stojcev, Zoran
Banasiewicz, Tomasz
Kaszuba, Michał
Sikorski, Adam
Szczepkowski, Marek
Bobkiewicz, Adam
Paszkowski, Jacek
Krokowicz, Łukasz
Biczysko, Maciej
Szmeja, Jacek
Jurkowska, Monika
Majewski, Przemysław
Mackiewicz, Andrzej
Lamperska, Katarzyna
Drews, Michał
Wojciechowicz, Jacek - Powiązania:
- https://bibliotekanauki.pl/articles/1039574.pdf
- Data publikacji:
- 2013
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
HNPCC
DNA microarray
colon cancer - Opis:
- Detection of mutations in families with a hereditary predisposition to colon cancer gives an opportunity to precisely define the high-risk group. 36 patients operated on for colon cancer, with familiar prevalence of this malignancy, were investigated using the DNA microarrays method with the potential detection of 170 mutations in MLH1, MSH2, MSH6, CHEK2, and NOD2 genes. In microarrays analysis of DNA in 9 patients (25% of the investigated group), 6 different mutations were found. The effectiveness of genetic screening using the microarray method is comparable to the effectiveness of other, much more expensive and time-consuming methods.
- Źródło:
-
Acta Biochimica Polonica; 2013, 60, 2; 195-198
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł