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Wyszukujesz frazę "Błażewicz, J." wg kryterium: Wszystkie pola


Wyświetlanie 1-4 z 4
Tytuł:
Magnetic Polymer Nanocomposite for Medical Application
Autorzy:
Świętek, M.
Tokarz, W.
Tarasiuk, J.
Wroński, S.
Błażewicz, M.
Powiązania:
https://bibliotekanauki.pl/articles/1197651.pdf
Data publikacji:
2014-04
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
82.35.Np
87.85.-d
87.85.Rs
75.75.-c
87.85.J-
87.85.Lf
Opis:
Magnetic sponges derived from biocompatible and resorbable polymers are promising materials for medical applications. These materials have been utilised extensively in research applications for the capture of biomolecules and cells, the construction of tissue scaffolds and in regenerative medicine. The object of this study was a polymer scaffold made of polycaprolactone (PCL) containing a 10 wt% amount of nanomagnetite, manufactured in a two-step method. The porosity and morphological parameters were characterised with the use of μ-computer-aided tomography and scanning electron microscopy. Furthermore, the magnetic properties were evaluated. The obtained results confirmed high porosity and the appearance of randomly oriented pores. Moreover, evaluations of the magnetic properties, of both the magnetite nanopowder and the prepared magnetic nanocomposite, were performed. The tests verified the ferromagnetic character of the materials under investigation.
Źródło:
Acta Physica Polonica A; 2014, 125, 4; 891-894
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Applications of Comet Assay for the Evaluation of Genotoxicity and DNA Repair Efficiency in Nanomaterials Research
Autorzy:
Panek, A.
Błażewicz, M.
Frączek-Szczypta, A.
Adamczyk, J.
Wiltowska-Zuber, J.
Paluszkiewicz, C.
Powiązania:
https://bibliotekanauki.pl/articles/1030633.pdf
Data publikacji:
2018-02
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
87.53.-j
87.85.jj
87.14.gk
Opis:
The single cell gel electrophoresis method, known as comet assay, is a rapid and sensitive technique for testing novel chemicals and nanoparticles for genotoxicity, monitoring environmental contamination with genotoxins and human biomonitoring. In our studies we check the applicability of this method for the evaluation of biocompatibility of modified (MWNF) and non-modified multi-walled carbon nanotubes (MWNT) as well as potential genotoxicity of mercury(II) nitrate. The obtained results enabled us to conclude that the presence of Hg(NO₃)₂ (p<0.001) and MWNT (p<0.04) cause a significantly higher level of DNA damage in comparison to functionalised nanomaterials MWNF. It was implied that for the three investigated agents only mercury significantly enhanced genotoxic effect of X-ray exposure (p<0.001) and inhibition of radio-induced DNA damage repair. On the contrary, the presence of MWNF have no influence on cellular repair efficiencies, while incubation with MWNT causes apoptosis and consequently results in lack of attached cells. In conclusion, our results confirmed the genotoxicity of mercury and non-modified carbon nanotubes as well as the biocompatibility of modified nanotubes. Additionally, we proved the usefulness of comet method for the evaluation of genotoxicity and DNA repair under the influence of different compounds and nanomaterials.
Źródło:
Acta Physica Polonica A; 2018, 133, 2; 280-282
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Titanium Surface Modification with Carbon Nanotubes. Towards Improved Biocompatibility
Autorzy:
Benko, A.
Wiecheć, A.
Rajchel, B.
Długoń, E.
Błażewicz, M.
Powiązania:
https://bibliotekanauki.pl/articles/1398806.pdf
Data publikacji:
2016-02
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
68.37.Hk
78.30.Na
81.15.Pq
82.45.Mp
87.85.J-
87.85.Rs
Opis:
Subject of this study is surface modification of titanium with thin layers of carbon nanotubes, obtained via an electrophoretic deposition, as a means to improve metal's biocompatibility and provide a suitable matrix for very facile further modifications, if needed. Article presents a preliminary evaluation of the material, using goniometer, scanning electron microscopy and the Raman spectroscopy. The layer is found to be composed of randomly distributed, strongly adhered carbon nanotubes, introducing nanotopography to the surface of titanium. Biological studies were conducted with the human osteoblast-like cell line MG63. Biocompatibility of materials was evaluated using: (a) lactate dehydrogenase cytotoxicity test (LDH) and (b) γ -H2AX genotoxicity test (presence of DNA double strand breaks). Results confirmed non-toxic character of the tested materials. Moreover, carbon nanotubes layers enhanced the biocompatibility properties of titanium substrate - material with carbon nanotubes possessed lower cellular toxic properties even than pure titanium. The result of this preliminary study are very promising and may serve as a starting point for further studies, including further chemical or biological modification of the obtained materials.
Źródło:
Acta Physica Polonica A; 2016, 129, 2; 176-178
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of magnetite composite on the amount of double strand breaks induced with X-rays
Autorzy:
Wiecheć, A.
Nowicka, K.
Błażewicz, M.
Kwiatek, W.
Powiązania:
https://bibliotekanauki.pl/articles/1065182.pdf
Data publikacji:
2016-02
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
87.50.-a
87.53.-j
81.05.Mh
81.05.Ni
81.05.Pj
81.05.Qk
75.50.Bb
Opis:
The aim of this study was to find out if polylactide (PLA) modified with magnetite might affect the amount of DNA double strand breaks induced with X-rays. The human osteosarcoma cells (MG63) were seeded on the polystyrene cell culture dishes (PS), PLA and PLA modified with magnetite substrates. The double strand breaks were analyzed after X-ray irradiation (dose rate 2 Gy/min), in the first day of culturing. The number of double strand breaks increased in the PLA modified with magnetite, for example after 1 Gy of X-rays irradiation, double strand breaks/cell equaled: 24.5 vs. 17.5 and 17.3, for PLA modified with magnetite vs. PLA and PS, p < 0.0003. We conclude that PLA modified with magnetite changed the number of double strand breaks induced with X-rays. However, more research is needed to confirm that such composite might be considered as radiosensitizer in radiotherapy.
Źródło:
Acta Physica Polonica A; 2016, 129, 2; 174-175
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-4 z 4

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