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Wyszukujesz frazę "quercetin" wg kryterium: Temat

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    Wyświetlanie 1-3 z 3
    Tytuł:
    Study of antioxidant activity of liposomal forms of quercetin and curcumin in ischemic heart disease
    Autorzy:
    Pylypenko, D.
    Gorbach, T.
    Krasnopolsky, Y.
    Powiązania:
    https://bibliotekanauki.pl/articles/2096332.pdf
    Data publikacji:
    2020
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    curcumin
    antioxidant
    quercetin
    liposomes
    oxidative stress markers
    Opis:
    Quercetin and curcumin are plant polyphenolic antioxidants with proven pharmacological efficacy. Their use is, however, limited due to low bioavailability and oral administration route. The encapsulation of lipophilic compounds in liposomes enables to increase their bioavailability and to create an injectable form. The present study aimed to comparatively investigate the antioxidant activity of a complex liposomal preparation containing two lipophilic antioxidants (quercetin and curcumin) and their monopreparations in liposomal forms. This study was conducted on Wistar line rats with experimental model of ischemic heart disease. Oxidative stress markers such as total antioxidant activity, malondialdehyde, and peroxidized proteins were analyzed in blood serum and cardiac tissue. Ischemic heart disease is accompanied with lipid peroxidation and changes in the activity of the antioxidant system. The obtained results demonstrated the antioxidant activity of monopreparations of curcumin and quercetin and their complex in liposomal forms. Quercetin and curcumin showed different antioxidant activities in terms of oxidative stress markers. The complex of the two antioxidants showed the synergistic effect of their lipophilic compounds in liposomal forms, which led to the normalization of test parameters according to the level of the control sample.
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2020, 101, 4; 273-282
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis of quercetin-functionalized silver nanoparticles by rapid one-pot approach
    Autorzy:
    Pandian, S.R.K.
    Kunjiappan, S.
    Ravishankar, V.
    Sundarapandian, V.
    Powiązania:
    https://bibliotekanauki.pl/articles/2096369.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    quercetin
    bioflavonoid
    one-pot synthesis
    AgNPs
    antioxidant
    Opis:
    Nanotechnology plays a pivotal role in all areas of science, and the synthesis and surface modification of nanoparticles are crucial in this field. Metal nanoparticles synthesized using plant extracts or phytocompounds are highly significant in the development of various therapeutics and diagnostics. In the present study, we report the one-pot and rapid synthesis of silver nanoparticles (AgNPs) by quercetin, a flavonoid found in various edible plants. The nanoparticles were then characterized using UV-VIS spectrophotometry, Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The role of quercetin in the synthesis of silver nanoparticles was demonstrated. The nanomaterial was 20–30 nm in size and spherical in shape. The silver nanoparticles were also confirmed to show antioxidant activity at 80 μg/ml concentration in vitro by DPPH, FRAP, and power reduction methods.
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2021, 102, 1; 75-84
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    In silico assessment of the inhibitory effect of four flavonoids (chrysin, naringin, quercetin, kaempferol) on tyrosinase activity using the MD simulation approach
    Autorzy:
    Farasat, A.
    Ghorbani, M.
    Gheibi, N.
    Shariatifar, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/2097135.pdf
    Data publikacji:
    2020
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    tyrosinase
    chrysin
    quercetin
    kaempferol
    naringin
    MD simulation
    Opis:
    Tyrosinase is a tetrameric enzyme that plays an important role in pigment production. Overproduction of melanin, which may lead to several skin disorders, is a result of tyrosinase activity. Hence, tyrosinase inhibitors are of key importance in the treatment of these disorders. In the present study, four flavonoid inhibitors, namely chrysin, naringin, quercetin, and kaempferol, were evaluated physiochemically, and the inhibitory effects of these compounds on tyrosinase activity were evaluated using the molecular dynamics (MD) simulation method. To create the best conformation of the enzyme-substrate/inhibitor, the docking process for enzyme-substrate, i.e., enzyme-chrysin, enzyme-quercetin, enzyme-naringin, and enzyme-kaempferol, was performed. The complexes with the best binding energies were selected as the models for the MD simulation process. Furthermore, the structural (RMSD, Rg, RMSF, and Distance) and the thermodynamics properties of the complexes were evaluated. Additionally, the PMF was conducted to calculate the binding free energies. The results showed that chrysin, quercetin and the substrate were at similar distances to the amino acids of the active site, but naringin and kaempferol were closer to the active site of the enzyme than the substrate. Moreover, the analysis of the binding energy revealed that the substrates, chrysin, kaempferol, quercetin, and naringin bound to the enzyme with binding energies of -7.8, -3.1, -7.1, -3.9, and -8.4 kcal/mol, respectively, which confirms that naringin has the highest inhibitory effect on tyrosinase among other inhibitors, which makes it an appropriate candidate as a whitening agent in skin disorders.
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2020, 101, 3; 193-204
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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