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    Wyświetlanie 1-6 z 6
    Tytuł:
    Survivin expression in correlation with apoptotic activity in canine lymphomas
    Autorzy:
    Sokolowska, J.
    Urbanska, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/32259.pdf
    Data publikacji:
    2017
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    Survivin regulates cell cycle and mitosis and has antiapoptotic properties. Because of its dual function survivin has been the subject of much research focusing on its role in tumorigenesis and the relationship between survivin expression and apoptotic and/or proliferative activity in many types of human tumor including non-Hodgkin’s Lymphomas. Such studies have not been conducted in canine lymphomas. The aim of this study was to evaluate the expression of survivin in canine lymphomas of low (5/25) and high (20/25) grades in relation to apoptotic markers (apoptotic index and index of caspase-3). Survivin was found in all examined lymphomas. Most tumors (18/25) showed survivin expression in 10%-25% of positive cells. Only in single cases was lower (0-10% positive cells, 1/25) or higher (25%-50% and >50% positive cells, 5/25 and 1/25, respectively) survivin expression. No significant differences between mean values of either index of survivin or apoptotic index was found between low and high grade lymphomas. However, such a difference among lymphoma grades was shown regarding the caspase-3 index. No correlation between the survivin index and either the apoptotic index or caspase-3 index was found, irrespective of the method of quantification: in whole specimens or in areas of low and high survivin expression. Positive correlation was consistently noted only between both apoptotic markers. The results indicate that survivin is commonly expressed in canine lymphomas. It seems that survivin does not exhibit anti-apoptotic activity in canine lymphomas. Lack of correlation between survivin expression and apoptotic markers could indicate its potential role in cell cycle activation in lymphoma cells.
    Źródło:
    Polish Journal of Veterinary Sciences; 2017, 20, 2
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Immunohistochemical assessment of metalloproteinases MMP2 and MMP9 expression in canine various subtypes of lymphomas in relation with proliferative and apoptotic markers
    Autorzy:
    Sokołowska, J.
    Urbańska, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087535.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    apoptotic markers
    dog
    immunolabelling
    lymphoma
    matrix metalloproteinases
    proliferative markers
    Źródło:
    Polish Journal of Veterinary Sciences; 2019, 2; 203-211
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ultrasonic quality assessment of polymer-cement concrete with PET waste as the aggregate
    Zastosowanie metody ultradźwiękowej do oceny jakości betonu polimerowo-cementowego zawierającego odpady PET
    Autorzy:
    Sokołowska, J. J.
    Zalegowski, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/230873.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    PCC
    beton polimerowo-cementowy
    badanie nieniszczące
    ocena jakości
    metoda ultradźwiękowa
    PET
    kruszywo odpadowe
    polymer-cement concrete
    non-destructive testing
    quality control
    ultrasonic method
    waste aggregate
    Opis:
    Elaborating composites containing waste materials requires study of basic mechanical properties and assessment of their structure quality. The subject of investigation was PPC concrete where aggregate was substituted with PET remaining after beverages bottles grinding. Substitution was done up to 25% (by volume). Waste material was fractioned and applied in various granulations. The main goal was to indicate the influence of such modification on the composite mechanical properties and to examine composite structure quality at macro level. Since PET and quartz differ greatly in density, to perform such examination it was possible to apply the nondestructive ultrasonic method, one of the most common NDT techniques used in material science and industry. The paper presents the effects of substitution of quartz with PET on ultrasonic wave propagation in PCC. The ultrasonic test results (measurements of wave velocity) compared with results of destructive tests (flexural and compressive strength) showed great correlation.
    Opracowanie nowego kompozytu zawierającego komponenty odpadowe wymaga nie tylko przeprowadzenia badań jego cech technicznych, ale też oceny jakości jego struktury. Przedmiotem badań zaprezentowanych w artykule był beton polimerowo-cementowy (PCC), w którym kruszywo częściowo (do 25% objętości) zastąpiono odpadem ze zmielonych butelek PET. Odpad był frakcjonowany i dodawany do mieszanek w różnej zawartości i granulacji. Celem badań było określenie wpływu takiej modyfikacji na właściwości mechaniczne oraz makrostrukturę kompozytu. Z uwagi na dużą różnicę w gęstościach kwarcu i poli(tereftalan etylenu) możliwe było zastosowanie metody ultradźwiękowej – jednej z najpowszechniej stosowanych w badaniach i przemyśle metod nieniszczących (NDT). W artykule zaprezentowano efekty substytucji kwarcu odpadem PET na propagację fal ultradźwiękowych w betonie PCC. Analiza statystyczna wyników pomiarów prędkości fali oraz wartości wytrzymałości na zginanie, wytrzymałości na ściskanie i gęstości pozornej poszczególnych kompozytów wskazuje na ich bardzo silną korelację.
    Źródło:
    Archives of Civil Engineering; 2018, 64, 2; 67-77
    1230-2945
    Pojawia się w:
    Archives of Civil Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Immunohistochemical detection of P-glycoprotein in various subtypes of canine lymphomas
    Autorzy:
    Sokolowska, J.
    Urbanska, K.
    Gizinski, S.
    Zabielska, K.
    Lechowski, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087980.pdf
    Data publikacji:
    2015
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    Combination chemiotherapy is the current standard of care for dogs with lymphoma. Multidrug resistance is one of the most important factors contributing to the efficacy of chemiotherapy. The major protein responsible for this phenomenon is P-glycoprotein. Little is known about P-glycoprotein expression in particular subtypes of lymphomas. The aim of the study was evaluation of P-glycoprotein expression in various subtypes of canine lymphomas. Positive reaction with P-glycoprotein was found in 12/25 cases of various morphological subtypes of lymphomas, however, in 3/11 lymphomas the percentage of positively weakly stained cells was <10% and those tumors were also considered negative. Tumors with 10-50% P-glycoprotein positive cells were found in single cases of centroblastic and centroblastic-centrocytic tumors. In 5 lymphomas P-glycoprotein expression exceeded 50% of tumor cells. Those cases were found among centroblastic, centroblastic-centrocytic, lymphoblastic and Burkitt-like subtypes. Positive reaction was observed mainly in the cell cytoplasm, however, in some cases prominent perinuclear dot-like staining pattern was found. In 2 cases focal staining pattern comprised dominant type of immunolabelling. Among all lymphomas containing P-glycoprotein positive cells intensity of imunolabelling was assessed as weak (6/25), moderate (2/25) and strong (3/25). Our results indicate that P-glycoprotein expression is present in nearly one third of newly diagnosed canine lymphomas of different morphological subtypes including those most commonly occurring, such as cenroblastic lymphomas. Hence, determination of P-glycoprotein expression at the time of diagnosis could provide valuable information for the design of treatment protocols. Moreover, our results have shown that P-glycoprotein expression in canine tumors could be located in Golgi-zone.
    Źródło:
    Polish Journal of Veterinary Sciences; 2015, 18, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Immunohistochemical study of expression of immunoglobulins in canine B-cell lymphomas
    Autorzy:
    Sokolowska, J.
    Micun, J.
    Zabielska, K.
    Malicka, E.
    Lechowski, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/31685.pdf
    Data publikacji:
    2010
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    immunohistochemistry
    expression
    immunoglobulin
    dog
    B cell
    lymphoma
    tumour
    neoplastic cell
    immunoglobulin light chain
    cancer
    Opis:
    Nineteen canine lymphomas were included in this study. Tumors were classified according to the updated Kiel classification adapted for canine lymphomas by Fournel-Fleury et al. Immunoglobulin light chains (κ and λ) and IgM and IgG expression were determined by immunohistochemical method. In all examined cases neoplastic cells were positive for one of the immunoglobulin light chains. Expression of λ light chains and κ light chains was observed in 18/19 and 1/19 tumors, respectively. In the majority of neoplastic cells in each examined specimen this reaction had a membranous pattern (sκ/sλ). In all examined cases the presence of immunoglobulin light chains was also observed in the cytoplasm of some neoplastic cells (cκ/cλ). These cells were usally rare and never constituted a dominant population. The expression of immunoglobulin was found in 13/19 cases. Most lymphomas were sIgM positive (11/13 cases). In one case expression of IgG was found, and in another lymphoma two populations of neoplastic cells with different expression of examined immunoglobulins (cells with IgM+ and IgG+ phenotypes) were observed. The reaction also had a membranous pattern. The cells containing cytoplasmic immunoglobulins were rare, and in most cases were of the same type as the surface immunoglobulins. Our study has confirmed that canine lymphomas are a monoclonal proliferation of B-cells usually expressing immunoglobulin λ light chains and that the vast majority of tumors deriving from B-cells express IgM. Our study also indicates a possibility of occurence of biclonal lymphomas in canine species.
    Źródło:
    Polish Journal of Veterinary Sciences; 2010, 13, 4
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Survivin expression in canine lymphomas in relation with proliferative markers
    Autorzy:
    Sokolowska, J.
    Urbanska, K.
    Gizinski, S.
    Wysocka, A.
    Cywinska, A.
    Lechowski, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087990.pdf
    Data publikacji:
    2015
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    Survivin is a member of apoptosis inhibiting proteins family. Apart from its antiapoptotic activity it plays a critical role in regulating the cell cycle and mitosis. It is overexpressed in most human malignancies. While the prognostic significance of survivin expression is widely investigated in human non-Hodgkin's lymphomas, little is known about its expression in canine lymphomas. The aim of the study was to evaluate the expression of survivin in canine lymphomas in relation to proliferation markers (mitotic index and percentage of Ki67-positive cells). Survivin was found in all examined lymphomas belonging to 6 different morphological subtypes with nuclear immunoreactivity. In most of lymphomas (18/25) survivin expression ranged 10%-25% of positive cells. Only single cases had lower (0-10% positive cells, 1/25) or higher (25-50% and >50% positive cells, 5/25 and 1/25, respectively) index of survivin. Neither mitotic index nor proliferative index correlated with survivin expression when the values quantified randomly in whole specimens were compared. However, when survivin expression were quantified in selected tumor areas of low and high proliferation activity the high correlations between survivin expression and proliferation index were found. The results indicated that survivin is commonly expressed in canine lymphomas. Nuclear labelling together with the relation of its expression and proliferative activity in highly proliferative areas of neoplastic tissue suggest a potential role of survivin in cell cycle activation in canine lymphoma cells. However, further studies of the relation between expression of survivin and other proteins involved in cell cycle regulation are needed. Moreover, the results suggest that survivin may pose the therapeutic target in canine lymphomas.
    Źródło:
    Polish Journal of Veterinary Sciences; 2015, 18, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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