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    Wyświetlanie 1-8 z 8
    Tytuł:
    Clinical observations on the course of oxytocin-or prostaglandin E2/oxytocin-induced parturition in mares
    Autorzy:
    Witkowski, M.
    Pawlowski, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087941.pdf
    Data publikacji:
    2014
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    The objective of this study was to compare the course of parturitions induced with sole oxytocin with those induced with the combination of intracervical prostaglandin E2 jelly and oxytocin. For this purpose 13 mares in advanced pregnancy were allocated to the groups pretreated with either intracervical PGE2 (experimental group) or saline (control group) two hours before intravenous oxytocin (5 IU) administration. The mares were compared with respect to cervical dilation diameter (CDD) 20 min. after oxytocin injection. Time intervals from the first oxytocin dose to: the first external signs of parturition, the chorioallantois rupture, the delivery of a foal and time interval from the delivery of a foal to the placenta separation were measured. Cervical dilatation diameter as well as proportion of mares with cervical dilatation > 20 cm were significantly higher in the group of PGE2 treated mares comparing with control group (p = 0.0115 and p = 0.0490, respectively). All time intervals measured were statistically insignificant for both groups of mares, however time intervals from the first oxytocin dose to the first external signs of parturition, to the allantochorion rupture and to the delivery of a foal, were very close to the significance level (α = 0.05). To conclude, PGE/oxytocin combination has positive influence on the preparation of the uterine cervix to parturition. Moreover, it seems that PGE2 pretreatment reduced total oxytocin dose for successful parturition induction and shortened time elapsing between the first oxytocin dose and the delivery of a foal what is crucial for foal’s safety.
    Źródło:
    Polish Journal of Veterinary Sciences; 2014, 17, 2; 347-351
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A role of ghrelin in cancerogenesis
    Autorzy:
    Majchrzak, K.
    Szyszko, K.
    Pawlowski, K.M.
    Motyl, T.
    Krol, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/31726.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    ghrelin
    cancerogenesis
    growth hormone secretagogue receptor
    cancer
    mammary cancer
    veterinary oncology
    oncology
    dog
    animal disease
    Opis:
    Ghrelin is a 28 amino-acid multi-functional peptide hormone, which was identified as a natural ligand of the growth hormone secretagogue receptor (GHS-R). Pituitary growth hormone-releasing activity in both animals and humans has been well documented. It has various biological functions, including regulation of appetite and body weight, control of energy homeostasis, modulation of cardiovascular and gastrointestinal system and anti-inflammatory effect. However, both ghrelin and its receptor (GHS-R) are widely distributed in various tumors, which strongly implies their role in neoplastic cell growth trough autocrine/paracrine mechanism. Multiple studies have demonstrated the role of ghrelin in cancer cells proliferation, differentiation, invasiveness and apoptosis inhibition. The ghrelin axis is more complex than it was originally thought and consist of several compounds that might interact with each other and affect ghrelin activities. Here, we provide an overview of the ghrelin and its receptor role in tumor progression.
    Źródło:
    Polish Journal of Veterinary Sciences; 2012, 15, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Canine mammary carcinoma cell line are resistant to chemosensitizers: verapamil and cyclosporin A
    Autorzy:
    Krol, M.
    Pawlowski, K.M.
    Majchrzak, K.
    Mucha, J.
    Motyl, T.
    Powiązania:
    https://bibliotekanauki.pl/articles/32199.pdf
    Data publikacji:
    2014
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    Cancer chemotherapy can fail in many ways. One of the most significant is the development of multiple drug resistance (MDR), which constitutes a serious clinical problem. The development of MDR relates to the expression of a major membrane pump, P-glycoprotein (P-gp). Thus, currently one of the goals of experimental and clinical oncology is to decrease its activity. So far, many different P-gp inhibitors are available, but their efficacy is still questionable and requires further study. The aim of our study was to assess an impact of classical P-gp inhibitors (verapamil and cyclosporin A) in the reversion of multidrug resistance in canine mammary cancer cells. We used two cell lines isolated from mammary tumors and two cell lines isolated from their lung metastases. All of them showed P-gp over-expression confirmed using Real-time rt-PCR, Skan^R screening station and confocal microscopy. The FACS analysis showed that in three of the examined cell lines, treatment with verpamil/cyclosporin A was ineffective to reverse cancer chemoresistance. However, more studies in this field are required.
    Źródło:
    Polish Journal of Veterinary Sciences; 2014, 17, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Gene expression pattern in canine mammary osteosarcoma
    Autorzy:
    Pawlowski, K.
    Majewska, A.
    Szyszko, K.
    Dolka, I.
    Motyl, T.
    Krol, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/32248.pdf
    Data publikacji:
    2011
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    bone tumour
    canine mammary osteosarcoma
    gene expression
    mammary osteosarcoma
    microarray
    osteosarcoma
    transcriptome
    tumour
    sarcoma
    proliferation
    aggressive tumour
    gene list
    Opis:
    Canine mammary sarcomas are usually very aggressive and easily metastasize. Unfortunately the biology of this type of tumor is not well known because they are a very rare type of tumors. The aim of this study was to find differences in gene expression patterns in canine mammary osteosarcomas (malignant) versus osteomas (benign) using DNA microarrays. Our microarray experiment showed that 11 genes were up-regulated in osteosarcoma in comparison to osteoma whereas 36 genes were down-regulated. Among the up-regulated genes were: PDK1, EXT1, and EIF4H which are involved in AKT/PI3K and GLI/Hedgehog pathways. These genes play an important role in cell biology (cancer cell proliferation) and may be essential in osteosarcoma formation and development. Analyzing the down-regulated genes, the most interesting seemed to be HSPB8 and SEPP1. HSPB8 is a small heat shock protein that plays an important role in cell cycle regulation, apoptosis, and breast carcinogenesis. Also SEPP1 may play a role in carcinogenesis, as its down-regulation may induce oxidative stress possibly resulting in carcinogenesis. The preliminary results of the present study indicate that the up-regulation of three genes EXT1, EIF4H, and PDK1 may play an essential role in osteosarcoma formation, development and proliferation. In our opinion the cross-talk between GLI/Hedgehog and PI3K/AKT pathways may be a key factor to increase tumor proliferation and malignancy.
    Źródło:
    Polish Journal of Veterinary Sciences; 2011, 14, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Density of tumor-associated macrophages (TAMs) and expression of their growth factor receptor MCSF-R and CD14 in canine mammary adenocarcinomas of various grade of malignancy and metastasis
    Autorzy:
    Krol, M.
    Pawlowski, K.
    Majchrzak, K.
    Dolka, I.
    Abramowicz, A.
    Szyszko, K.
    Motyl, T.
    Powiązania:
    https://bibliotekanauki.pl/articles/32107.pdf
    Data publikacji:
    2011
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    adenocarcinoma
    canine adenocarcinoma
    density
    dog
    expression
    growth factor
    immunohistochemistry
    immunology
    malignancy
    mammary adenocarcinoma
    metastasis
    tissue sample
    tumour microenvironment
    tumour-associated macrophage
    Opis:
    Several years ago, the presence of macrophages in the tumor microenvironment was thought to be an inflammatory response to kill the cancer cells. Now, this is clear that the inflammatory cells that exit blood vessels and migrate to the tumor tissue play an important role in cancer progression. Various cells present in the tumor microenvironment enhance cancer growth and invasiveness by secretion of tumor-enhancing products. That is why tumors should not be treated as only aggregates of cancer cells but as separate structures. Macrophages form a major component of the inflammatory infiltration in tumors, where they are termed tumor-associated macrophages (TAMs). To the best of our knowledge, up-to-date there were no studies on tumor associated macrophages and the role of the tumor microenvironment in tumor invasion/metastasis in dogs. This is the first study performed to asses if the number of TAMs and expression of MCSF-R (macrophages colony stimulating factor receptor) and CD14 (LPS co-receptor) are associated with the grade of tumor malignancy and its ability to metastasize. We have performed immunohistochemical analysis of 50 canine mammary adenocarcinomas of various grade of malignancy (1st, 2nd, 3rd) and tumors that gave local or distant metastases. The results indicate that in dogs, similarly to humans and mice, the number of tumor associated macrophages is related to the cancer ability to metastasize. Our results also indicate that the expression of MCSF-R and, what is particularly new finding, CD14 is associated with tumor malignancy and its ability to metastasize. Hence, these molecules play a role in tumor progression, metastasis and microenvironment interactions. These results show that in dogs we should treat the tumor as a whole organ rather than just try to eliminate the cancer cells.
    Źródło:
    Polish Journal of Veterinary Sciences; 2011, 14, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sintered nanosilver joints on rigid and flexible substrates
    Autorzy:
    Kiełbasiński, K.
    Szałapak, J.
    Młożniak, A.
    Teodorczyk, M.
    Pawłowski, R.
    Krzemiński, J.
    Jakubowska, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/201549.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    silver nanopowder
    pressure sintering
    thermal conductivity
    nanoproszek srebra
    spiekanie ciśnieniowe
    przewodność cieplna
    Opis:
    Because of new EU laws restricting the use of harmful substances (i.e. Pb because of the RoHS Directive), the search for new methods of joining has become highly urgent. The main problem for most solutions known to date has been to achieve good electrical parameters while maintaining low sintering temperaturatures. Pastes based on silver nanoparticles were developed, which allow to sinter below 300 ° C. Those layers have sheet resistance below 2 mΩ/sq. Low exposure to heat allows to use these pastes on elastic substrates such as paper or Kapton foil. In present work, the authors proved that it is possible to obtain joints on elastic substrates which can withstand over 30 000 cycles in bend test, with sintering in 300°C, by means of the Low Temperature Joining Technique (LTJT).
    Źródło:
    Bulletin of the Polish Academy of Sciences. Technical Sciences; 2018, 66, 3; 325-331
    0239-7528
    Pojawia się w:
    Bulletin of the Polish Academy of Sciences. Technical Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A Method Of Calculating Thermal Diffusivity And Conductivity For Irregularly Shaped Specimens In Laser Flash Analysis
    Autorzy:
    Szałapak, J.
    Kiełbasiński, K.
    Krzemiński, J.
    Młożniak, A.
    Zwierkowska, E.
    Jakubowska, M.
    Pawłowski, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/220433.pdf
    Data publikacji:
    2015
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    thermal diffusivity
    LFA
    LTJT joints
    high power electronics
    Opis:
    The Low Temperature Joining Technique (LTJT) using silver compounds enables to significantly increase the thermal conductivity between joined elements, which is much higher than for soldered joints. However, it also makes difficult to measure the thermal conductivity of the joint. The Laser Flash Analysis (LFA) is a non-intrusive method of measuring the temperature rise of one surface of a specimen after excitation with a laser pulse of its other surface. The main limitation of the LFA method is its standard computer software, which assumes the dimensions of a bonded component to be similar to those of the substrate, because it uses the standard Parker’s formula dedicated for one-dimensional heat flow. In the paper a special design of measured specimen was proposed, consisting of two copper plates of different size joined with the sintered silver layer. It was shown that heat properties of these specimens can also be measured after modifying the LFA method. The authors adapted these specimens by masking the false heat signal sourced from the uncovered plate area. Another adaptation was introducing a correcting factor of the heat travel distance, which was calculated with heat-flow simulations and placed into the Parker’s formula. The heat-flow simulated data were compared with the real LFA measurement results, which enabled estimation of the joint properties, e.g. its porosity.
    Źródło:
    Metrology and Measurement Systems; 2015, 22, 4; 521-530
    0860-8229
    Pojawia się w:
    Metrology and Measurement Systems
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The Effect of Two-Stage Age Hardening Treatment Combined with Shot Peening on Stress Distribution in the Surface Layer Of 7075 Aluminum Alloy
    Wpływ dwuetapowego procesu starzenia połączonego z kulowaniem na rozkład naprężeń w warstwie wierzchniej stopu aluminium 7075
    Autorzy:
    Kaczmarek, Ł.
    Zawadzki, P.
    Stegliński, M.
    Wójcik, R.
    Klich, M.
    Kyzioł, K.
    Kottfer, D.
    Januszewicz, J.
    Pawłowski, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/356022.pdf
    Data publikacji:
    2015
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    aluminum
    heat treatment
    multi stage
    shot peening
    residual stress
    aluminium
    obróbka cieplna
    starzenie dwuetapowe
    śrutowanie
    naprężenie ściskające
    Opis:
    The article present the results of the study on the improvement of mechanical properties of the surface layer of 7075 aluminum alloy via two-stage aging combined with shot peening. The experiments proved that thermo-mechanical treatment may significantly improve hardness and stress distribution in the surface layer. Compressive stresses of 226 MPa±5.5 MPa and hardness of 210±2 HV were obtained for selected samples.
    W ramach niniejszego artykułu przedstawiono wyniki badań dotyczące poprawy właściwości mechanicznych warstwy wierzchniej w stopie aluminium 7075 poprzez kombinacje starzenia dwuetapowego i kulowania. Dowiedziono w ramach prowadzonych badań, że istnieje możliwość znacznego poprawienia twardości oraz rozkładu naprężeń w warstwie wierzchniej stosując obróbkę cieplno-plastyczną. Dla wybranych próbek uzyskiwano naprężenia ściskające na poziomie 226MPa±5,5 MPa oraz twardość rzędu 210±2 HV.
    Źródło:
    Archives of Metallurgy and Materials; 2015, 60, 3A; 1993-1997
    1733-3490
    Pojawia się w:
    Archives of Metallurgy and Materials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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