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Wyszukujesz frazę "Markiewicz, T." wg kryterium: Autor

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    Wyświetlanie 1-11 z 11
    Tytuł:
    An Energy Efficient QAM Modulation with Multidimensional Signal Constellation
    Autorzy:
    Markiewicz, T. G.
    Powiązania:
    https://bibliotekanauki.pl/articles/227049.pdf
    Data publikacji:
    2016
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    communication system
    QAM modulation
    lattice
    multidimensional constellations
    Opis:
    Packing constellations points in higher dimensions, the concept of multidimensional modulation exploits the idea drawn from geometry for searching dense sphere packings in a given dimension, utilising it to minimise the average energy of the underlying constellations. The following work analyses the impact of spherical shaping of the constellations bound instead of the traditional, hyper-cubical bound. Balanced constellation schemes are obtained with the N-dimensional simplex merging algorithm. The performance of constellations of dimensions 2, 4 and 6 is compared to the performance of QAM modulations of equivalent throughputs in the sense of bits transmitted per complex (twodimensional) symbols. The considered constellations give an approximately 0.7 dB to 1 dB gain in terms of BER over a standard QAM modulation.
    Źródło:
    International Journal of Electronics and Telecommunications; 2016, 62, 2; 159-165
    2300-1933
    Pojawia się w:
    International Journal of Electronics and Telecommunications
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Thresholding techniques for segmentation of atherosclerotic plaque and lumen areas in vascular arteries
    Autorzy:
    Markiewicz, T.
    Dziekiewicz, M.
    Osowski, S.
    Maruszyński, M.
    Kozłowski, W.
    Bogusławska-Walecka, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/201734.pdf
    Data publikacji:
    2015
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    image processing
    thresholding methods
    computed tomography
    vascular image parameterization
    przetwarzanie obrazu
    metody progowania
    tomografia komputerowa
    Opis:
    The paper develops the automatic methods of segmentation of the blood vessel area in the images of the multi-slice computed tomography, allowing to separate the lumen from the atherosclerotic plaque areas. The solution is based on the application of different implementations of thresholding, including between class variance in a bimodal mode, Gaussian mixture modeling, clustering technique, polynomial and multilayer perceptron approximations. These methods are compared with many examples of arteries of different percentage of the plaque occupancy in the iliac and femoral arteries. The numerical results of segmentation have been verified by the medical experts and prove its usefulness in medical practice. The presented system can find application in an automatic evaluation of the atherosclerosis progression/regression of patients on the basis of sequence of Computed Tomography slice images.
    Źródło:
    Bulletin of the Polish Academy of Sciences. Technical Sciences; 2015, 63, 1; 269-280
    0239-7528
    Pojawia się w:
    Bulletin of the Polish Academy of Sciences. Technical Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Deep learning for damaged tissue detection and segmentation in Ki-67 brain tumor specimens based on the U-net model
    Autorzy:
    Swiderska-Chadaj, Z.
    Markiewicz, T.
    Gallego, J.
    Bueno, G.
    Grala, B.
    Lorent, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/202412.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    damaged tissue regions detection
    artifacts detection
    deep learning
    Ki-67 staining specimens
    wykrywanie uszkodzonych regionów tkankowych
    wykrywanie artefaktów
    artefakt
    uczenie głębokie
    próbki barwiące Ki-67
    Opis:
    The pathologists follow a systematic and partially manual process to obtain histological tissue sections from the biological tissue extracted from patients. This process is far from being perfect and can introduce some errors in the quality of the tissue sections (distortions, deformations, folds and tissue breaks). In this paper, we propose a deep learning (DL) method for the detection and segmentation of these damaged regions in whole slide images (WSIs). The proposed technique is based on convolutional neural networks (CNNs) and uses the U-net model to achieve the pixel-wise segmentation of these unwanted regions. The results obtained show that this technique yields satisfactory results and can be applied as a pre-processing step for automatic WSI analysis in order to prevent the use of the damaged areas in the evaluation processes.
    Źródło:
    Bulletin of the Polish Academy of Sciences. Technical Sciences; 2018, 66, 6; 849-856
    0239-7528
    Pojawia się w:
    Bulletin of the Polish Academy of Sciences. Technical Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Modified nucleic acids as an anti-aging agents
    Autorzy:
    Rolle, K.
    Markiewicz, W.T.
    Barciszewski, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/80015.pdf
    Data publikacji:
    2014
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    skin aging process
    natural aging process
    anti-aging agent
    nucleic acid
    4-furfurylcytosine
    biological property
    cosmetic
    patent
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2014, 95, 4
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    New inhibitors of DNA methyltransferase 1 based on cytosine scaffold
    Autorzy:
    Fedoruk-Wyszomirska, A.
    Markiewicz, W.T.
    Barciszewski, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/79872.pdf
    Data publikacji:
    2016
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2016, 97, 4
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Non-nucleosidic analogs of nucleic acids
    Autorzy:
    Brzezinska, J.
    Adrych-Rozek, K.
    Jahnz-Wechmann, Z.
    Boryski, J.
    Markiewicz, W.T.
    Powiązania:
    https://bibliotekanauki.pl/articles/80212.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    nucleic acid
    oligonucleotide
    oligonucleotide analogue
    non-nucleosidic nucleic acid
    glycerol nucleic acid
    natural nucleobase
    ring system
    hydrolysis
    biological membrane
    non-radioactive probe
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2012, 93, 4
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sesquicentennial of the discovery of DNA. Forgotten Professor Richard Altmann from Iława
    Autorzy:
    Zubek, Aniela
    Belter, Agnieszka
    Naskręt-Barciszewska, Mirosława Z.
    Stefan, Jurga
    Markiewicz, Wojciech T.
    Barciszewski, Jan
    Powiązania:
    https://bibliotekanauki.pl/articles/704410.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    Richard Altmann
    DNA
    nucleic acids
    mitochondria
    Opis:
    This year we are celebrating 150 anniversary of the discovery of DNA by Friedrich Miescher. His finding initiated a series of discoveries that allowed to depicts life's most famous molecule with novel features with considerable biological interest. In this article we recall the biggest mile stones of 150-year history of DNA and present the context and meaning of several key observations that have brought us closer to understanding DNA. 150 years ago, people had no idea that DNA existed, and they certainly hadn’t heard of DNA structure and sequencing. We now know that DNA is a dynamic, tortuous coil, constantly shuffling and unwinding. Today DNA is all around us, in a physical sense and in a cultural sense. It is really part of our culture. We will discuss also the little known facts, often overlooked in similar discussions. We will focus particularly on Professor Richard Altmann's from Iława, whose contribution to knowledge about nucleic acids is significant, although not well recognized so far.
    Źródło:
    Nauka; 2019, 1
    1231-8515
    Pojawia się w:
    Nauka
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Application of epoxy functional silanes in the preparation of DNA microarrays
    Autorzy:
    Frydrych-Tomczak, E.
    Uszczynska, B.
    Ratajczak, T.
    Markiewicz, W.T.
    Figlerowicz, M.
    Nowicki, M.
    Maciejewski, H.
    Chmielewski, M.K.
    Powiązania:
    https://bibliotekanauki.pl/articles/80900.pdf
    Data publikacji:
    2014
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    DNA microarray
    gene expression
    organofunctional silane
    oligonucleotide
    atomic force microscopy
    goniometer
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2014, 95, 1
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of the influence of meloxicam and flunixin meglumine on the apoptosis of peripheral blood CD4plus and CD8plus T cells in calves
    Autorzy:
    Maslanka, T
    Jaroszewski, J.J.
    Markiewicz, W.
    Jabubowski, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/31556.pdf
    Data publikacji:
    2010
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    peripheral blood
    T cell
    calf
    CD4plus T cell
    CD8plus T cell
    apoptosis
    meloxicam
    flunixin meglumine
    lymphocyte
    antiinflammatory drug
    Opis:
    The aim of the study was to determine whether treatment with recommended doses of meloxicam or flunixin had an effect on the apoptosis of peripheral blood T lymphocytes in calves. The study was carried out on 4-5 months old calves (n = 24, 8 per group). Experimental animals were injected subcutaneously with a single dose of 0.5 mg . kg-1 of meloxicam or intravenously with 3 doses of 2.2 mg . kg-1 day-1 of flunixin. The non-treatment animals served as control. Blood samples were taken at day 0 and at days 1, 2, 3, 5, 7 and 14 after the first NSAIDs injection. Apoptosis was determined by flow cytometry using Annexin V-PE/7-AAD staining. The kinetic analysis of apoptosis in the total lymphocyte population, as well as in the CD4+ and CD8+ subsets did not reveal significant differences in the frequency of early apoptotic cells between control and experimental groups throughout the period studied. Although, 24 h after administration of the first dose of NSAIDs, late-stage apoptosis/necrosis was significantly increased in the total lymphocyte population (the meloxicam group), as well as in the CD4+ (the meloxicam group and the flunixin group) and CD8+ (the flunixin group) subsets of T cells. However, this disturbance was transient, relatively poorly expressed and, thus, unlikely to be of clinical significance. Our results indicate that the use of meloxicam or flunixin in accordance with the recommended dosage regimen in cattle do not have a clinically significant influence on apoptosis of peripheral blood T cells.
    Źródło:
    Polish Journal of Veterinary Sciences; 2010, 13, 1; 3-12
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Participation of analogues of lysophosphatidic acid (LPA): oleoyl-sn-glycero-3-phosphate (L-α-LPA) and 1-oleoyl-2-O-methyl-rac-glycerophosphothionate (OMPT) in uterine smooth muscle contractility of the pregnant pigs
    Autorzy:
    Markiewicz, W.
    Kaminska, K.
    Bogacki, M.
    Maslanka, T.
    Jaroszewski, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/30322.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    Recent studies show that a representative of phospholipids, namely lysophosphatidic acid (LPA) and its receptors (LPA1-3) play a significant role in the reproductive processes, i. a, in the modulation of the uterine contractility. The participation of LPA3 in the reproductive processes has been revealed in mice and has not been studied in gilts. Therefore, in the present study we investigated the role/action of LPA and its receptors LPA1, LPA2 and LPA3 on the contraction activity in the porcine uterus. The study was conducted on an experimental model in which the pig uterus consisted of the one whole uterine horn and a part of the second horn, both connected with the uterine corpus. Uterine strips consisting of the endometrium with the myometrium (ENDO/MYO) and myometrium (MYO) alone were collected on days 12-14 of the estrous cycle (control group; n = 5) or pregnancy (experimental group; n = 5). Two analogues of LPA at increasing doses were used: oleoyl-sn-glycero- 3-phosphate (L-α-LPA, a selective agonist of LPA1 and LPA2 receptors; 10-7 M; 10-6 M and 10-5 M) and 1-oleoyl-2-O-methyl-rac-glycerophosphothionate (OMPT, a selective agonist of LPA3 receptor; 68 nM; 136 nM and 680 nM). L-α-LPA caused an increase in the contraction tension, amplitude and frequency of ENDO/MYO from the uterine horn with the developing embryos. This effect was not observed in MYO in both groups examined. In the ENDO/MYO strips of the uterine horn with developing embryos, OMPT significantly increased the contraction tension at the highest dose (680 nM) and amplitude at all doses examined, while frequency of contractions was decreased at doses of 136 nM and 680 nM. In the MYO strips of the uterine horn with embryos a significant increase in the contraction tension and amplitude after the highest dose of OMPT was observed. The results obtained imply the important role of receptors LPA1 , LPA2 and LPA3 in the contraction activity of the porcine uterus during early pregnancy.
    Źródło:
    Polish Journal of Veterinary Sciences; 2012, 15, 4
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The presence of CD25 on bovine WC1 plus gamma delta T cells is positively correlated with their production of IL-10 and TGF-beta, but not IFN-gamma
    Autorzy:
    Maslanka, T.
    Jaroszewski, J.J.
    Markiewicz, W.
    Ziolkowski, H.
    Barski, D.
    Powiązania:
    https://bibliotekanauki.pl/articles/32183.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    cattle
    WC1 cell
    T cell
    T lymphocyte
    transforming growth factor-beta
    interleukin 10
    interferon-gamma
    CD25 antigen
    CD25 molecule
    Opis:
    WC1+ cells in cattle exhibit both regulatory and effector activities. However, it has not been elucidated whether they are so plastic that both activities co-exist in one cell or there are separate subpopulations of effector and regulatory cells. Since the production of IFN-γ and IL-10 seems to be related to WC1+ cells’ effector and regulatory function, respectively, the main aim of this study was to determine whether those cytokines are produced by separate subpopulations of WC1+, or are co-produced by the same cells. Due to increasingly frequent emphasised role of consumption of IL-2 in the mechanism of suppressor action of mouse CD25+CD4+ T regulatory cells, expression of the receptor’s α chain for interleukin 2 (CD25) on WC1+ lymphocytes has been evaluated. An average of 5.21% of WC1+ cells obtained from PBMCs of 12-month-old heifers show constitutive expression of the CD25 molecule, with CD25highWC1+ and CD25lowWC1+ cells accounting for 1.05% and 4.10% of WC1+ lymphocytes, respectively. For detection of intracellular cytokine production, PBMCs were stimulated with concanavalin A. Both IFN-γ- and IL-10-producing cells within the CD25-WC1+ and CD25+WC1+ subpopulations were mainly separate subpopulations. The average percentage of IFN-γ+IL-10-, IFN-γ-IL-10+ and IFN-γ+IL-10+ cells among CD25-WC1+ lymphocytes was 4.03%, 2.67% and 0.51%, respectively. A positive correlation was observed between the presence of the CD25 molecule on WC1+ lymphocytes and production of IL-10 and TGF-β, because the average percentage of IFN-γ-IL-10+ and IFN-γ+IL-10+ among CD25+WC1+ lymphocytes was 3 and 4.5 times higher as compared to the corresponding cells in the CD25-WC1+ subpopulation, whereas the percentage of IFN-γ+IL-10- cells in both the subpopulations was not significantly different. The percentage of TGF-β+ cells within the CD25+WC1+ subpopulation was 2.72 times as high as that of CD25-WC1+ lymphocytes. Therefore, with respect to the production of IFN-γ, IL-10 and TGF-β, CD25+WC1+ lymphocytes turn out to have a more suppressor profile than CD25-WC1+.
    Źródło:
    Polish Journal of Veterinary Sciences; 2012, 15, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-11 z 11

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