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    Wyświetlanie 1-4 z 4
    Tytuł:
    Modern Alphaset (APNB) Flexible Formulations-Enhanced Performance
    Autorzy:
    Ghosh, D. K.
    Powiązania:
    https://bibliotekanauki.pl/articles/1837863.pdf
    Data publikacji:
    2020
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    make molds and cores
    sand binder
    resin performance
    alkaline phenolic no-bake
    APNB
    wytwarzenie form i rdzeni
    spoiwo piaskowe
    właściwości żywic
    Opis:
    APNB (alkaline phenolic no bake), widely known as Alphaset is one of the major sand binder systems used in foundries to make molds and cores without application of heat or gas. This is a two part system comprising of a phenol-formaldehyde resin in alkaline medium as binder and range of esters of dibasic acids and/or polyhydric alcohols as hardeners. Resin performance varies depending upon formulations. Major variables in formulations are mole ratio of phenol: formaldehyde, total alkali content, ratio of two alkalis (NaOH & KOH) and molecular weight of polymers i.e. chain length. In present work, one mole ratio of phenol & formaldehyde has been chosen to prepare 8 resins [...].
    Źródło:
    Archives of Foundry Engineering; 2020, 20, 4; 18-28
    1897-3310
    2299-2944
    Pojawia się w:
    Archives of Foundry Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Speech and Music – Nonlinear Acoustical Decoding in Neurocognitive Scenario
    Autorzy:
    Bhaduri, S.
    Ghosh, D.
    Powiązania:
    https://bibliotekanauki.pl/articles/177385.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    speech signal
    multifractality
    Visibility Graph
    Fractal Darwinism
    neurocognitive disorders
    Opis:
    Speech and music signals are multifractal phenomena. The time displacement profile of speech and music signal show strikingly different scaling behaviour. However, a full complexity analysis of their frequency and amplitude has not been made so far. We propose a novel complex network based approach (Visibility Graph) to study the scaling behaviour of frequency wise amplitude variation of speech and music signals over time and then extract their PSVG (Power of Scale freeness of Visibility Graph). From this analysis it emerges that the scaling behaviour of amplitude-profile of music varies a lot from frequency to frequency whereas it’s almost consistent for the speech signal. Our left auditory cortical areas are proposed to be neurocognitively specialised in speech perception and right ones in music. Hence we can conclude that human brain might have adapted to the distinctly different scaling behaviour of speech and music signals and developed different decoding mechanisms, as if following the so called Fractal Darwinism. Using this method, we can capture all non-stationary aspects of the acoustic properties of the source signal to the deepest level, which has huge neurocognitive significance. Further, we propose a novel non-invasive application to detect neurological illness (here autism spectrum disorder, ASD), using the quantitative parameters deduced from the variation of scaling behaviour for speech and music.
    Źródło:
    Archives of Acoustics; 2018, 43, 4; 593-602
    0137-5075
    Pojawia się w:
    Archives of Acoustics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Navigation of autonomous mobile robot using different activation functions of wavelet neural network
    Autorzy:
    Panigrahi, P. K.
    Ghosh, S.
    Parhi, D. R.
    Powiązania:
    https://bibliotekanauki.pl/articles/229613.pdf
    Data publikacji:
    2015
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    autonomous mobile robot
    activation functions
    obstacle avoidance
    path planning
    wavelet neural network
    Opis:
    An autonomous mobile robot is a robot which can move and act autonomously without the help of human assistance. Navigation problem of mobile robot in unknown environment is an interesting research area. This is a problem of deducing a path for the robot from its initial position to a given goal position without collision with the obstacles. Different methods such as fuzzy logic, neural networks etc. are used to find collision free path for mobile robot. This paper examines behavior of path planning of mobile robot using three activation functions of wavelet neural network i.e. Mexican Hat, Gaussian and Morlet wavelet functions by MATLAB. The simulation result shows that WNN has faster learning speed with respect to traditional artificial neural network.
    Źródło:
    Archives of Control Sciences; 2015, 25, 1; 21-34
    1230-2384
    Pojawia się w:
    Archives of Control Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Design, molecular docking, drug-likeness, and molecular dynamics studies of 1,2,4-trioxane derivatives as novel Plasmodium falciparum falcipain-2 (FP-2) inhibitors
    Autorzy:
    Ghosh, S.
    Chetia, D.
    Gogoi, N.
    Rudrapal, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2096418.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    1
    2
    4-trioxane
    Plasmodium falciparum
    drug resistance
    molecular docking
    molecular dynamics
    falcipain 2 inhibitors
    Opis:
    Despite significant progress made in drug discovery and development over the past few decades, malaria remains a life-threatening infectious disease across the globe. Because of the widespread emergence of drug-resistant strains of Plasmodium falciparum, the clinical utility of existing drug therapies including Artemisinin-based Combination Therapies (ACTs) in the treatment of malaria has been increasingly limited. It has become a serious health concern which, therefore, necessitates the development of novel drug molecules and/or alternative therapies to combat, particularly resistant P. falciparum. The objective of the present study was to develop 1,2,4-trioxane derivatives as novel antimalarial agents that would be effective against resistant P. falciparum. In our study, 15 new trioxane derivatives were designed by molecular modification of the 1,2,4-trioxane scaffold as possible antimalarial agents. Molecular modeling studies of trioxane derivatives were performed based on the CADD approach using Biovia Discovery Studio (DS) 2018 software. The protein-ligand docking study was performed against P. falciparum falcipain 2 (FP-2) using the simulation-based docking protocol LibDock by the flexible docking method. The assessment of drug-likeness, ADMET properties, and toxicity was also performed. Furthermore, the compounds CC3 and CC7, which showed the best binding affinity against the target P. falciparum FP-2, were investigated by molecular dynamics (MD) simulation studies followed by the calculation of MM-PBSA binding free energy of protein-ligand complexes using DS 2020. Results of the docking study showed that among the 15 compounds, three trioxane derivatives were found to possess promising binding affinity with LibDock scores ranging from 117.16 to 116.90. Drug-likeness, ADMET, and toxicity properties were found to be satisfactory for all the compounds. Among the 15 compounds, two compounds, namely CC3 and CC7, showed the highest binding affinity against FP-2 with LibDock score of 117.166 and 117.200, respectively. The Libdock score of the co-crystal inhibitor was 114.474. MD studies along with MM-PBSA calculations of binding energies further confirmed the antimalarial potential of the compounds CC3 and CC7, with the formation of well-defined and stable receptor-ligand interactions against the P. falciparum FP-2 enzyme. Additionally, the selectivity of trioxane hits identified as potential inhibitors of P. falciparum cysteine protease FP-2 was determined on human cysteine proteases such as cathepsins (Cat K and Cat L), which are host homologous. Finally, it was concluded that the newly designed 1,2,4-trioxane derivatives can be further studied for in vitro and in vivo antimalarial activities for their possible development as potent antimalarial agents effective against resistant P. falciparum
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2021, 102, 3; 257-275
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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