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    Wyświetlanie 1-7 z 7
    Tytuł:
    Concentration of hepatic vitamins A and E in rats exposed to chlorpyrifos and/or enrofloxacin
    Autorzy:
    Spodniewska, A.
    Barski, D.
    Powiązania:
    https://bibliotekanauki.pl/articles/31712.pdf
    Data publikacji:
    2016
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    The aim of the study was to determine the level of antioxidant vitamins A and E in the liver of rats exposed to chlorpyrifos and/or enrofloxacin. Chlorpyrifos (Group I) was administered at a dose of 0.04 LD50 (6 mg/kg b.w.) for 28 days, and enrofloxacin (Group II) at a dose of 5 mg/kg b.w. for 5 consecutive days. The animals of group III were given both of the mentioned above compounds at the same manner as groups I and II, but enrofloxacin was applied to rats for the last 5 days of chlorpyrifos exposure (i.e. on day 24, 25, 26, 27 and 28). Chlorpyrifos and enrofloxacin were administered to rats intragastrically via a gastric tube. The quantitative determination of vitamins was made by the HPLC method. The results of this study indicated a reduction in the hepatic concentrations of vitamins A and E, compared to the control, which sustained for the entire period of the experiment. The four-week administration of chlorpyrifos to rats resulted in a significant decrease of vitamins in the initial period of the experiment, i.e. up to 24 hours after exposure. For vitamin A the maximum drop was observed after 24 hours (19.24%) and for vitamin E after 6 hours (23.19%). Enrofloxacin caused a slight (3-9%) reduction in the level of the analysed vitamins. In the chlorpyrifos-enrofloxacin co-exposure group reduced vitamins A and E levels were also noted, but changes in this group were less pronounced in comparison to the animals intoxicated with chlorpyrifos only. The decrease in the antioxidant vitamin levels, particularly noticeable in the chlorpyrifos- and the chlorpyrifos combined with enrofloxacin-treated groups, may result not only from the increase in the concentration of free radicals, but also from the intensification of the secondary stages of lipid peroxidation.
    Źródło:
    Polish Journal of Veterinary Sciences; 2016, 19, 2
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Activity of selected antioxidative enzymes in rats exposed to dimethoate and pyrantel tartrate
    Autorzy:
    Barski, D.
    Spodniewska, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/32333.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    This study presents the results of research concerning the effect of single and combined application of pyrantel tartrate and dimethoate on selected antioxidative enzymes: catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx), in rat erythrocytes. Pyrantel tartrate was applied twice, at a dose of 85 mg/kg bw at a two week interval, i.e. on day 14 and 28 of the experiment, orally, in a water solution with a stomach tube. Dimethoate was administered with drinking water for 28 days at a dose of 25 mg/kg bw/day. It was found that pyrantel tartrate caused only small changes in the activity of the antioxidative enzymes under analysis. Subchronic exposure of rats to dimethoate caused a significant increase in the activity of CAT, SOD and GPx in erythrocytes, indicating the existence of strong oxidative stress. In combined intoxication, no significant effects of administering pyrantel tartrate on the activity of CAT, SOD and GPx was found in animals poisoned with dimethoate. The profile of changes was similar to that observed in rats exposed only to the organophosphorus insecticide. This may indicate a lack of interaction between the compounds used in the experiment.
    Źródło:
    Polish Journal of Veterinary Sciences; 2012, 15, 2
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Activity of superoxide dismutase, catalase and glutathione peroxidase in rats exposed to chlorpyrifos and erofloxacin
    Autorzy:
    Barski, D.
    Spodniewska, A.
    Zasadowski, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/32363.pdf
    Data publikacji:
    2011
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    The aim of the study was to investigate the influence of administration of chlorpyrifos and/or enrofloxacin on the activity of chosen antioxidative enzymes i.e.: superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in erythrocytes of rats. Chlorpyrifos was administered by stomach tube during 28 days at a dose of 3 mg/kg bw (0.02 LD50), and enrofloxacin was administered by stomach tube at a dose of 5 mg/kg bw during 3 subsequent days. It was stated that administration of enrofloxacin at applied dose did not cause any major changes in the activity of investigated antioxidative enzymes. The four-week exposure of rats to chlorpyrifos caused noticeable decrease in SOD and CAT activity in erythrocytes of rats at the beginning of the experiment (up to 24th hour) in comparison with the control group. The activity of GPx during all periods of the experiment was increased. In the group of animals in which both chlorpyrifos and enrofloxacin were applied, the profile of changes in activity of examined enzymes was similar to that one, which was observed after administration of chlorpyrifos exclusively, what may indicate lack of co-action between compounds used in the experiment.
    Źródło:
    Polish Journal of Veterinary Sciences; 2011, 14, 4
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Glutathione and glutathione-related enzymes in rats exposed to dimethoate and/or pyrantel
    Autorzy:
    Spodniewska, A.
    Barski, D.
    Ziolkowski, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/32042.pdf
    Data publikacji:
    2014
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    The study was undertaken to examine the effect of single and combined administration of dimethoate (an OP insecticide) and pyrantel embonate (an anthelmintic agent) on the concentration of reduced glutathione (GSH) and the activity of glutathione peroxidase (GPx) and glutathione reductase (GR) in rats. Dimethoate (Group I) was administered to rats at a dose of 1/10 LD₅₀ for 5 consecutive days and pyrantel embonate (Group II) at a dose of 1/5 LD₅₀ for 3 consecutive days. The animals of group III were given both of the mentioned above compounds in the same manner as group I and II, but pyrantel embonate was applied on day 3, 4, and 5 from the beginning of dimethoate intoxication. Material from 6 rats randomly selected from each group was obtained after 3, 6 and 12 hours and 2, 7 and 14 days following the last applied dose of the compounds under study. It was found that application of pyrantel embonate caused only slight changes in the analysed parameters i.e. GSH, GPx and GR. Dimethoate administration caused disturbances in the antioxidative system manifested as a decrease in GSH concentration in the liver (max. - 37.7% after 6 hours) and an increase of GPx and GR activities in erythrocytes (max. - 21.7% and 29.6% after 3 hours, respectively), compared to the control group. The profile of changes after combined intoxication was similar, but their intensity was higher compared to the group of animals exposed to dimethoate only. Based on current studies, it was concluded that both dimethoate and pyrantel embonate at the applied doses showed a pro-oxidative activity.
    Źródło:
    Polish Journal of Veterinary Sciences; 2014, 17, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of chlorpyrifos and enrofloxacin on selected enzymes in rats
    Autorzy:
    Barski, D.
    Spodniewska, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087764.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    chlorpyrifos
    enrofloxacin
    AChE
    ALT
    AST
    rats
    Źródło:
    Polish Journal of Veterinary Sciences; 2018, 21, 1; 39-46
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of doxazosin, an alpha1-adrenergic receptor antagonist on the urinary bladder contractility in pigs
    Autorzy:
    Markiewicz, W.
    Jasielska, A.
    Barski, D.
    Janiuk, J.
    Bossowska, A.
    Jaroszewski, J.J.
    Powiązania:
    https://bibliotekanauki.pl/articles/31189.pdf
    Data publikacji:
    2014
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    In the present study influence of doxazosin on the porcine urinary bladder contractility has been examined. Immature pigs were treated for 30 days with: a) doxazosin (n = 5) per os at a dose of 0.1 mg/kg b.w. or b) placebo (n = 5; control group). Thereafter, animals were sacrificed and urinary bladder strips from the trigone were suspended in organ baths. The tension of the smooth musce was measured before and after exposition to acetylocholine (ACh; 10⁻⁵ - 10⁻³ M), norepinephrine (NE; 10⁻⁹ - 10⁻⁷ M) and 5-hydroxytryptamine (5-HT; 10⁻⁷ - 10⁻⁵ M). Both the ACh and 5-HT at the highest doses significantly increased the contractility in each group, but this response was weaker in doxazosin-treated animals. NE caused relaxation in both groups, but the effect was weaker in doxazosine-treated group. The results of our study have shown that long-term administration of doxazosin caused a desensitization of the detrusor smooth muscle for in vitro applied mediators of the autonomic nervous systems.
    Źródło:
    Polish Journal of Veterinary Sciences; 2014, 17, 3
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Structural health monitoring (SHM) methods in machine design and operation
    Zastosowanie badań nieniszczących (SHM) w projektowaniu i eksploatacji maszyn
    Autorzy:
    Barski, M.
    Kędziora, P.
    Muc, A.
    Romanowicz, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/139723.pdf
    Data publikacji:
    2014
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    structural health monitoring
    non-destructive testing
    finite element method
    FEM
    spectral finite element method
    composite materials
    monitorowanie stanu technicznego
    badania nieniszczące
    metoda elementów skończonych
    MES
    metoda skończonych elementów spektralnych
    materiały kompozytowe
    Opis:
    The present paper is devoted to the discussion and review of the non-destructive testing methods mainly based on vibration and wave propagation. In the first part, the experimental methods of actuating and analyzing the signal (vibration) are discussed. The piezoelectric elements, fiber optic sensors and Laser Scanning Doppler Vibrometer (SLDV) method are described. Effective detecting of the flaws needs very accurate theoretical models. Thus, the numerical methods, e.g. finite element, spectral element method and numerical models of the flaws in isotropic and composite materials are presented. Moreover, the detection of the damage in structures, which are subjected to cyclic or static loads, is based on the analyzing of the change in natural frequency of the whole structure, the change of internal impedance of the material and the change in guided waves propagating through the investigated structure. All these cases are characterized in detail. At the end of this paper, several applications of the structural health monitoring systems in machine design and operation are presented.
    Obecnie prezentowana praca poświęcona jest zagadnieniom związanym z szeroko rozumianym pojęciem badań nieniszczących. Dotyczy to przede wszystkim metod opartych na analizie drgań jak również propagacji fal sprężystych w elementach konstrukcji maszyn. Pierwsza część pracy zawiera przegląd najczęściej wykorzystywanych typów wzbudników oraz czujników, a mianowicie przetworników piezoelektrycznych, włókien optycznych. Przegląd ten uzupełniono opisem zaawansowanej technologii pomiaru drgań przy wykorzystaniu technik laserowych. Zebrane w ten sposób dane muszą być następnie odpowiednio przetworzone tak, aby uzyskać informacje na temat występowania uszkodzeń, ich lokalizacji i rozmiaru. W tym celu niezbędne jest przygotowanie odpowiednich modeli teoretycznych opartych na technologii Metody Elementów Skończonych lub Elementów Spektralnych. Ponadto, należy również opracować i przetestować komputerowe modele uszkodzeń w materiałach izotropowych jak również kompozytowych. Istnienie uszkodzenia w materiale powodować może zmianę wartości częstotliwości drgań własnych oraz odpowiadających im form drgań, impedancji mechanicznej jak również zakłócenia w rozchodzeniu się fal sprężystych. Przypadki te omówiono szczegółowo w niniejszej pracy. Przegląd ten uzupełniono wybranymi przykładami praktycznego zastosowania powyższych technik kontroli stanu konstrukcji.
    Źródło:
    Archive of Mechanical Engineering; 2014, LXI, 4; 653-677
    0004-0738
    Pojawia się w:
    Archive of Mechanical Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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