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    Wyświetlanie 1-5 z 5
    Tytuł:
    The evaluation of resorbable haemostatic wound dressings in contact with blood in vitro
    Autorzy:
    Szymonowicz, M.
    Kucharska, M.
    Wiśniewska-Wrona, M.
    Dobrzyński, M.
    Kołodziejczyk, K.
    Rybak, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/306978.pdf
    Data publikacji:
    2017
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    opatrunek
    chitozan
    alginian
    mikrofibrydy
    nanofibrydy
    hemoliza
    haemostatic
    dressing
    chitosan-alginate
    nanofibrids
    microfibrids
    haemolysis
    plasmatic clotting system
    Opis:
    Purpose: For many years research has been conducted on the development of resorbable, polymer, haemostatic materials designed to provide first aid and preliminary protection of injuries. The biological properties in vitro of a dressing in powder form called Hemoguard are expected to provide the ability to instantaneously stem bleeding with safe conditions of use. The aim of the study was to evaluate the haemostatic properties of a model of dressing based on micro- and nanofibrids of the chitosan, sodium/calcium alginate and/or carboxymethylcellulose complex. Dressings were prepared by spray-drying and freeze-drying. Methods: Human whole blood was subjected to timed contact with the haemostatic dressing model. Haemolytic action was determined by assaying the degree of haemolysis and evaluating blood cell morphology. Haemostatic action was determined on the basis of selected parameters of plasmatic clotting systems. Results: Dressings prepared by freeze-drying activated the coagulation system. The haemolytic index, plasma haemoglobin concentration values and blood cell morphological shapes were normal. Dressings prepared by spray-drying significantly activated coagulation. Activation of the coagulation process was evidenced by shorter clotting time of the plasma coagulation system and a longer process of clot formation. The dressing was associated with an increased haemolytic index and higher plasma haemoglobin concentration. The morphological shape of blood cells changed. Conclusions: The model of multi-resorbable wound dressings has haemostatic properties. The materials activate the clotting process more quickly than a single-dressing model. Increased activity was found for dressings prepared by spray-drying.
    Źródło:
    Acta of Bioengineering and Biomechanics; 2017, 19, 1; 151-165
    1509-409X
    2450-6303
    Pojawia się w:
    Acta of Bioengineering and Biomechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Haemocompatibility and cytotoxic studies of non-metallic composite materials modified with magnetic nano and microparticles
    Autorzy:
    Szymonowicz, M.
    Rybak, Z.
    Fraczek-Szczypta, A.
    Paluch, D.
    Rusak, A.
    Nowicka, K.
    Blazewicz, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/306490.pdf
    Data publikacji:
    2015
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    nanokompozyty
    cząstki magnetyczne
    hemoliza
    żywotność komórkowa
    koagulacja
    nanocomposite
    magnetic particles
    polysulfone
    haemolysis
    cell viability
    coagulation systems
    Opis:
    Purpose: Preventing the formation of blood clots on the surface of biomaterials and investigation of the reasons of their formation are the leading topics of the research and development of biomaterials for implants placed into the bloodstream. Biocompatibility and stability of a material in body fluids and direct effect on blood cell counts components are related both to the structure and physico-chemical state of an implant surface. The aim of this study was to determine haemocompatibility and cytotoxicity of polysulfone-based samples containing nano and micro particles of magnetite (Fe3O4). Methods: The polysulfone-based samples modified with nanometric and micrometric magnetite particles were examined. Physicochemical properties of the composites were determined by testing their wettability and surface roughness. The action of haemolytic, activation of coagulation system and cytotoxicity of composites was evaluated. Results: Wettability and roughness of materials were correlated with nanoparticles and microparticles content. In the tests of plasma coagulation system shortening of activated partial thromboplastin time for polysulfone with nano magnetite and with micro magnetite particles was observed in comparison with pure polysulfone. Prothrombine time and thrombine time values as well as fibrinogen concentration were unchanged. Haemolysis values were normal. Morphology and viability of cells were normal. Conclusions: Composites made from polysulfone modified with nanoparticles and microparticles of magnetite cause neither haemolytic nor cytotoxic reaction. These composites evoke plasma endogenous system activation.
    Źródło:
    Acta of Bioengineering and Biomechanics; 2015, 17, 3; 49-58
    1509-409X
    2450-6303
    Pojawia się w:
    Acta of Bioengineering and Biomechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    On influence of anodic oxidation on thrombogenicity and bioactivity of the Ti-13Nb- 13Zr alloy
    Autorzy:
    Szymonowicz, M.
    Kazek-Kęsik, A.
    Sowa, M.
    Żywicka, B
    Rybak, Z.
    Simka, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/951810.pdf
    Data publikacji:
    2017
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    stopy tytanu
    utlenianie anodowe
    modyfikacja powierzchni
    krew
    vanadium-free titanium alloys
    anodic oxidation
    surface modification
    blood compatibility
    Opis:
    Purpose: This paper reports the results of investigations of the blood response of the modified titanium alloys surfaces. Methods: To enhance biocompatibility of the Ti-13Nb-13Zr alloy, anodisation was performed at 80 and 150 V. The oxidation process was carried out in a solution containing 4 mol dm−3 H3PO4 and 0.59 mol dm−3 Ca(H2PO2)2. Results: The haemolytic activity of the titanium alloy surface was not altered much by the anodisation. The obtained values of the percentage of haemolysis were well below the levels required for the materials intended for blood contact. The clotting time of the blood was similar for the as-ground sample and the sample anodised at 80 V. For the sample anodised at 150 V the clotting time was shorter. The differences between these samples were observed in partial thromboplastin time after activation, prothrombin time and thrombin time, after 24 h. Extracts taken from the samples were not toxic towards the L-929 mouse fibroblast cells. Conclusions: The proposed treatment might be appropriate for the preparation of the modified Ti-13Nb-13Zr surfaces intended for bone reconstruction or cardiovascular implants depending on process parameters.
    Źródło:
    Acta of Bioengineering and Biomechanics; 2017, 19, 2; 41-50
    1509-409X
    2450-6303
    Pojawia się w:
    Acta of Bioengineering and Biomechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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