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Wyświetlanie 1-3 z 3
Tytuł:
Measurement and analysis of the air pressure curve on the rigid lenses by use of ocular response analyzer
Autorzy:
Kasprzak, H.
Mazur, E.
Widlicka, M.
Powiązania:
https://bibliotekanauki.pl/articles/307438.pdf
Data publikacji:
2014
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
okulistyka
ciśnienie śródgałkowe
lepkosprężystość
ORA
ocular viscoelasticity
intraocular pressure
air pressure curve
Opis:
Purpose: Pressure curves obtained from Ocular Response Analyzer (ORA) differ for the same patient in form and height. In some cases measurements on the subject show significant differences between recorded pressure curves. The purpose of the paper is to examine if the differences result from the corneal properties or from the device operation. Methods: Examination of air pressure curves was carried out on four plano-convex glass lenses with radii of curvature close to the central corneal radius. Lenses were mounted in front of the air jet of the ORA analyzer. Series of 30 measurements on each lenses were recorded with 20s and 60s time interval between measurements. Results were exported to computer and analyzed numerically Results: Results show much higher reproducibility of pressure curves in every series of measurements in comparison to pressure curves recorded on the patients eye. This demonstrates that ORA produces air pulses with high reproducibility. Conclusions: Differences in air pressure pulses for the real eye can indicate the dynamics of ocular properties during measurements. Obtained pressure curves are not symmetrical and not well fitted by Gaussian curve. Type of asymmetry of air pressure curves may be explained by viscoelasticity of air.
Źródło:
Acta of Bioengineering and Biomechanics; 2014, 16, 4; 117-121
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Raw data from Ocular Response Analyzer applied for differentiation of normal and glaucoma patients
Autorzy:
Jóźwik, Agnieszka
Asejczyk-Widlicka, Magdalena
Boszczyk, Agnieszka
Kasprzak, Henryk
Krzyżanowska-Berkowska, Patrycja
Powiązania:
https://bibliotekanauki.pl/articles/173859.pdf
Data publikacji:
2020
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
glaucoma
intraocular pressure
Ocular Response Analyzer
raw data
tonometry
Opis:
Purpose: Presented study describes new parameters calculated from the Ocular Response Analyzer (ORA) raw data. Such an approach can increase the applicability of the ORA in ophthalmic diagnosis. Among many proposed and examined by us parameters from raw data of the air pressure and applanation curves, only a few were chosen and then applied for characterizing a selected group of patients. Methods: The study included healthy subjects in a control group and patients divided into 2 groups: suspect and glaucoma. A series of four ORA measurements were taken from each subject. The raw ORA data were numerically analyzed and new parameters were calculated from the ORA curves for each measurement. Comparative analysis was carried out for the newly proposed parameters (and original parameters from the ORA device). Results: This interesting finding is that the new parameters showed a statistically significant ability to distinguish the glaucoma suspect group from healthy and glaucomatous patients. Moreover comparable or higher repeatability than for IOPg and CH was obtained. Conclusion: Raw data from the ORA enables definition and numerical analysis of new parameters, characterizing every measurement, which can be successfully used for describing an individual eye and differentiating between some specific groups of patients.
Źródło:
Optica Applicata; 2020, 50, 1; 147-159
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Daily disposable contact lenses as a platform for ocular drug delivery of cyclosporine A
Autorzy:
Michałkiewicz, Ola
Nowak, Iwona
Nowak, Rafał
Rykowska, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/24085732.pdf
Data publikacji:
2023
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
contact lens
cyclosporine A
vitamin E
drug delivery systems
dry eye syndrome
Opis:
Ophthalmic drug delivery is an important area of research that aims to improve the efficacy and convenience of treatment for various eye conditions. There are multiple ways in which drugs can be delivered to the eye, including eye drops, ointments, gels, and inserts. The most prevalent way of administering medication to the eye is through eye drops. They are easy to use and can be self-administered by patients. Nonetheless, eye drops have the disadvantage of being prone to removal by tears, which may result in insufficient drug absorption and reduced effectiveness. Irregular use of active substances can exacerbate the disease, resulting in prolonged treatment with questionable efficacy. Soft contact lenses that serve as ophthalmic drug delivery systems (DDS) can become a viable substitute for traditional treatments. These polymeric lenses can be embedded with various active compounds, some of which are not readily soluble in water or physiological fluids. One such drug is Cyclosporine A (CyA), an immunosuppressant with a high molecular weight and hydrophobic properties, chronically used to treat dry eye syndrome (DES). The article discusses the development of a method for modifying Hilafilcon B contact lenses obtained from drugstores with Cyclosporine A (CyA). The drug was administered to the lenses using an immersion technique, and the process parameters were monitored to control drug release efficiency and profile. The drug release was measured in an Artificial Lacrimal Fluid (ALF) buffer, mimicking tear fluid with a pH of 7.9. The stability of CyA in this buffer was assessed. For the parameters used, the best drug application and release profile was achieved by immersing the contact lenses for 24 hours at 25°C in a CyA solution containing 20 μg/ml of the active substance and adding 5 mg/ml of Vitamin E.
Źródło:
Physicochemical Problems of Mineral Processing; 2023, 59, 4; art. no. 172794
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-3 z 3

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