- Tytuł:
- Conformational studies of tachykinin peptides using NMR spectroscopy
- Autorzy:
-
Rodziewicz, S.
Xiao-Fei, Qi.
Rolka, K. - Powiązania:
- https://bibliotekanauki.pl/articles/1954059.pdf
- Data publikacji:
- 1998
- Wydawca:
- Politechnika Gdańska
- Tematy:
-
conformational analysis
tachykinin peptides
NMR spectroscopy
Scyliorhinin II
molecular dynamics calculation methods
DMSO - Opis:
- Conformational analysis of two tachykinin family peptides: Scyliorhinin I (ScyI) and Scyliorhinin II (ScyII) was carried out by 1D- and 2D-NMR (DQF-COSY, TOCSY, HMQC, HMBC, NOESY and ROESY) and molecular dynamics calculation methods in water and DMSO. Scyliorhinin I is an equipotent agonist of NK-1 and NK-2 tachykinin receptors and Scyliorhinin II is a selective agonist of the NK-3 tachykinin receptor. In DMSO, two groups of conformations (major and minor) were obtained for both peptides based on the experimental data. The conformations proposed for ScyI represent a folded structure, which show certain similarities to the structures reported for other NK-1 and NK-2 tachykinin agonists. In water ScyII displays a flexible, extended structure, whereas in DMSO the structure is more compact and in the fragment from the centre to the C-terminus several beta -turns may be present.
- Źródło:
-
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 1998, 2, 1; 47-53
1428-6394 - Pojawia się w:
- TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
- Dostawca treści:
- Biblioteka Nauki
Artykuł