Temat: overall survival - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Metastatic pancreatic adenocarcinoma treated with liposomal irinotecan in combination with 5-fluorouracil and leucovorin as a II line chemotherapy
Autorzy:: Kraj, Leszek
Gryziak, Maciej
Żurawińska-Grzelka, Ewa
Woźniak, Krzysztof
Powiązania:: https://bibliotekanauki.pl/articles/2047205.pdf
Data publikacji:: 2021-06-30
Wydawca:: Medical Education
Tematy:: II line chemotherapy
liposomal irinotecan
leucovorin
peripheral polyneuropathy
overall survival
pancreatic cancer
Opis:: The paper presents a case of a 54-year-old man with pancreatic tumor and intraperitoneal dissemination. The patient received treatment with gemcitabine in combination with nab-paclitaxel. After 18 months, the disease progressed, therefore the line of treatment was applied in the form of liposomal irinotecan with 5-FU/LV. This therapy provided progression-free survival for 7 months. The obtained results are better than the median progression-free survival obtained in the studies. This case demonstrates that liposomal irinotecan in the treatment of stage IV disease in patients progressing after gemcitabine opens up new treatment options.
Źródło:: OncoReview; 2021, 11, 2; 44-47
2450-6125
Pojawia się w:: OncoReview
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Long-term response with everolimus for metastatic renal cell carcinoma refractory to sunitinib-sorafenib sequence
Autorzy:: Kardas, Joanna
Buraczewska, Agnieszka
Powiązania:: https://bibliotekanauki.pl/articles/1065215.pdf
Data publikacji:: 2015
Wydawca:: Medical Education
Tematy:: clear cell carcinoma
mTOR inhibitor (mTORi)
metastatic renal cell cancer
overall survival (OS)
progression free survival (PFS)
tyrosine kinase inhibitor (TKI)
Opis:: We presented a 39-year-old male who developed progressive cancer disease 4 years after nephrectomy due to clear cell carcinoma. He was diagnosed with locally reccurence and metastases to the liver, spleen and abdominal muscles. The patient was treated with sunitinib and then after disease progression – with sorafenib. We observed 18 months of cancer control (TKI-TKI). After second progression everolimus was administered. Third line everolimus therapy helped to achieve durable stable disease with PFS 46 months till now (May 2015). The patient remains in very good performance status with minimal toxicity from the regimen. This case illustrates a long term survival for patients with metastatic renal cell carcinoma, a malignancy with historically poor prognosis. The use of three sequential targeted therapies (TKI – TKI – mTORi) helped to achieve over 5 years or disease control, with rarely seen long-term response to third line treatment (mTORi) – where stabilization is good enough. We discussed therapeutic strategies in metastatic renal cell carcinoma according to the literature and therapeutic possibilities in Poland.
Źródło:: OncoReview; 2015, 5, 2; A71-75
2450-6125
Pojawia się w:: OncoReview
Dostawca treści:: Biblioteka Nauki

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