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    Wyświetlanie 1-7 z 7
    Tytuł:
    Analysis of 7965 screening colonoscopies and treatment results of detected colorectal cancers – experiences of one center
    Autorzy:
    Nowicki, Andrzej
    Kula, Zbigniew
    Lemanowicz, Marzena
    Powiązania:
    https://bibliotekanauki.pl/articles/1064862.pdf
    Data publikacji:
    2016
    Wydawca:
    Medical Education
    Tematy:
    National Screening Program for Early Detection of Colorectal Cancer
    colorectal cancer
    screening colonoscopy
    Opis:
    Introduction: Colorectal cancer is one of the most common cancers in both sexes and is one of the leading causes of death in Poland and the world. An effective method to prevent the development of colorectal cancer (CRC) is the detection of polyps during a screening colonoscopy and their removal. Objective: The aim of the study was to evaluate results of screening for early detection of colorectal cancer by colonoscopy. Material and methods: The study was based on analysis of medical records of 7965 patients who underwent colonoscopy as part of the National Screening Program (NSP) for Early Detection of Colorectal Cancer in the 2000–2014 period. Results: Polyps were removed in 2900 (36.4%) patients, among whom 1885 (23.6%) had adenomas, which were more frequent in men (32.9%). Tubular adenomas were observed in 1685 patients (21.1%), tubulo-villous adenomas were detected in 157 patients (2%) and villous adenomas – in 43 (0.5%) of them. Sixty-three (0.79%) colorectal cancers were detected in various clinical stages, including adenocarcinoma in situ in 3 patients. Probability of 5-year survival rate of colorectal cancer amounted to 74% while 10-years survival was reached in 63% of patients. Conclusions: The detection rate of polyps, adenomas and carcinomas thanks to screening colonoscopy was 36.4%, 23.6% and 0.79% respectively, while the probability of 5-year survival was 74%. An improvement in the quality of colonoscopy was observed in subsequent years of the NSP, which translated into better detection of adenomas.
    Źródło:
    OncoReview; 2016, 6, 3; A134-142
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Variability of clinical characteristic of colorectal cancer patients – analysis of selected parameters
    Autorzy:
    Copija, Angelika
    Głogowski, Łukasz
    Walkiewicz, Katarzyna
    Janion, Karolina
    Nowakowska-Zajdel, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1035800.pdf
    Data publikacji:
    2018
    Wydawca:
    Medical Education
    Tematy:
    clinical features
    colorectal cancer
    epidemiology
    Opis:
    Introduction: A steady increase of the incidence of colorectal cancer has been observed for over 30 years, particularly in well-developed countries. Colorectal cancer is one of the lifestyle-related neoplasms and depends on environmental factors. Aim: Aim of the study was to analyse selected clinical features of colorectal cancer patients. Material and methods: The study group consisted of 577 consecutive patients with colorectal cancer treated in the Department of Clinical Oncology in Bytom in 2006–2014. The patients were included into the study prospectively. The analysis of selected clinical, pathological and anthropometrical parameters was conducted. Results: The study group included 237 women and 341 men aged 26 to 86 years (mean age 64.3 ± 9.2 years). Primary tumours were mostly located in the colon and had histological grade 2. The surgical removal of the primary tumour was performed in 540 patients. 65 patients underwent preoperative radiotherapy, 201 – postoperative chemotherapy and 91 – postoperative radio-chemotherapy. 132 of patients obtained the first-line palliative chemotherapy. 88 of patients did not received oncological treatment. KRAS/RAS mutation were determined in 73 patients and the EGFR expression status in 53 patients. Conclusions: Colorectal cancer patients are a heterogeneous group with differential clinical, pathological and molecular features. 1. Therapeutic management of patients with colorectal cancer largely depends on its location, clinical and pathological stage, patients performance status and comorbidities. 2. Understanding the clinical features of patients with colorectal cancer becomes helpful in designing of screening, which take into account clinical profile of the patient, i.e. age, gender, comorbidities and anthropometric characteristics
    Źródło:
    OncoReview; 2018, 8, 3; 80-85
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Selected psychosocial aspects of life of patients with a stoma
    Autorzy:
    Nowicki, Andrzej
    Farbicka, Paulina
    Powiązania:
    https://bibliotekanauki.pl/articles/1064909.pdf
    Data publikacji:
    2016
    Wydawca:
    Medical Education
    Tematy:
    colorectal cancer
    psycho-oncology
    stoma
    Opis:
    Cancer causes huge problems, physical and mental nature mainly. In particular, we cannot forget about the functioning of these patients in the social and spiritual spheres. The increasing trend of incidence of rectal cancer makes the disease is becoming a priority for doctors, nurses and psycho-oncologists. Despite the increasing quality of medical services, patients face a number of problems associated with cancer treatment, which may result in formation of a colostomy. The procedure, which is necessary to save the patient’s life, is often perceived by them as “mutilation”. Acceptance of the disease and satisfaction of life in patients with a stoma after the operation for rectal cancer are dependent on many factors. Social support, living conditions and the time elapsed since creation of the stoma have great impact. “Stoma nurse” plays an extremely important role. Seeing the difficulties in adapting the stoma she should verify the patient’s pessimism as to his/her own self, develops a sense of responsibility from minor to major issues and strengthen a sense of independence.
    Źródło:
    OncoReview; 2016, 6, 2; A72-76
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    PTEN – clinical significance in colorectal cancer
    Autorzy:
    Copija, Angelika
    Waniczek, Dariusz
    Walkiewicz, Katarzyna
    Głogowski, Łukasz
    Augustyniak, Henryk
    Nowakowska-Zajdel, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1064929.pdf
    Data publikacji:
    2016
    Wydawca:
    Medical Education
    Tematy:
    EGFR-targeted therapy
    PTEN
    colorectal cancer
    Opis:
    Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a human suppressor gene. Its protein product is a bispecific phosphatase playing the complex role in the cell cycle regulating processes and apoptosis by the mechanism of signal transduction into the cell via tyrosine kinase B signaling pathway (PI3K/Akt/mTOR). Reduction or loss of PTEN function is implicated in the pathogenesis of many malignancies, including colorectal cancer. A gradual decrease in the function of PTEN in the sequence of transformations: normal tissue–polyp–adenocarcinoma – disseminated cancer was indicated. The relation between the PTEN loss and the higher clinical severity of colorectal cancer was observed, i.a. higher TNM status and higher tendency to form metastases, leading in some of the studies to shortened patients survival during the observation period. The potential predictive value of the PTEN function loss for the EGFR-targeted therapy in patients with advanced colorectal cancer is the subject of controversy. The potential application of PTEN assessment in clinical practice as a prognostic and/or predictive factor requires further well-designed prospective studies on larger patient population, using the unified methodology. The aim of the study is to summarize the current knowledge on the role of PTEN gene and PTEN protein in the pathogenesis of colorectal cancer and the role of PTEN in clinical practice.
    Źródło:
    OncoReview; 2016, 6, 2; A86-90
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Complications of palliative antiangiogenic therapy in patients with colorectal cancer
    Autorzy:
    Domagała-Haduch, Małgorzata
    Jasiówka, Marek
    Nowak, Łukasz
    Cedrych, Ida
    Powiązania:
    https://bibliotekanauki.pl/articles/1064817.pdf
    Data publikacji:
    2016
    Wydawca:
    Medical Education
    Tematy:
    adverse effects
    bevacizumab
    colorectal cancer
    treatment safety
    Opis:
    Introduction: Bevacizumab is an antiangiogenic drug used in the therapy of numerous solid tumours including colorectal adenocarcinoma. The efficacy and safety of bevacizumab has been demonstrated in many multicenter clinical trials. The scope of this paper is to analyze the safety profile of bevacizumab in patients with stage IV colorectal cancer. Aim of the study: Analysis of toxicity and safety of the treatment with bevacizumab patients with colorectal cancer in the metastatic stage. Material and methods: Retrospective analysis of medical records of 42 patients with advanced colorectal cancer treated in the Department of Systemic and Generalized Malignancies, Maria Skłodowska-Curie Memorial Institute of Oncology, Kraków Branch, in the period 2007–2014. Results: The median time of treatment with bevacizumab was 6 months. The median duration of progression-free survival (PFS) was 8.5 months. Toxicity of treatment with bevacizumab affected 43 percent of patients. The most common adverse events observed was hypertension and bleeding. In 6 patients (14.3%) the treatment with bevacizumab was interrupted due to adverse events (thromboembolic events, bleeding and gastrointestinal perforation). Conclusions: Bevacizumab is a safe therapeutic option in patients with metastatic colorectal cancer, provided that patients are provided close oncological and general medical monitoring.
    Źródło:
    OncoReview; 2016, 6, 4; A199-204
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of activation of insulin-like growth factors in colorectal cancer
    Autorzy:
    Walkiewicz, Katarzyna
    Nowakowska-Zajdel, Ewa
    Strzelczyk, Joanna
    Walczak, Michał
    Copija, Angelika
    Janion, Karolina
    Muc-Wierzgoń, Małgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/1062926.pdf
    Data publikacji:
    2017
    Wydawca:
    Medical Education
    Tematy:
    IGF-receptors
    colorectal cancer
    insulin-like growth factors
    metabolic disorders
    Opis:
    Co-occurrence of metabolic disorders is a recognized risk factor for the development of colorectal cancer which is currently the leading cause of morbidity due to malignant neoplasms in the world. The pathogenesis of colorectal cancer is not well understood yet. Among the postulated neoplastic mechanisms is the activation of insulin-like growth factors, with both epidemiological and clinical observations of their role. In this paper, the authors synthesize the current knowledge about the importance of activation of insulin-like growth factors in the development of colorectal cancer.
    Źródło:
    OncoReview; 2017, 7, 3; 116-120
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Thrombosis of the deep dorsal penile vein and corpora cavernosa of the penis as the first symptoms of colon cancer. Case report and literature review
    Autorzy:
    Roslan, Marek
    Przudzik, Maciej
    Borowik, Michał
    Wronka, Henryk
    Kozielec, Zygmunt
    Michalak, Maciej
    Grabysa, Radosław
    Powiązania:
    https://bibliotekanauki.pl/articles/1035859.pdf
    Data publikacji:
    2020-11-17
    Wydawca:
    Medical Education
    Tematy:
    corpus cavernosus thrombosis
    deep dorsal penile vein thrombosis
    metastatic colorectal cancer
    Opis:
    The case describes an 86-year-old man with thrombosis of the deep dorsal vein and corpora cavernosa of the penis who developed symptoms 4 months before hospitalisation. An accurate imaging diagnostics supplemented with a biopsy of the corpus cavernosum confirmed the initial diagnosis. Moreover, an adenocarcinoma of the hepatic flexion of the colon with numerous metastatic lesions, including those to the crus of penis were found. Diagnostic and therapeutic difficulties were described and the results obtained were discussed in the context of available literature.
    Źródło:
    OncoReview; 2020, 10, 3; 98-102
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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