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    Wyświetlanie 1-8 z 8
    Tytuł:
    Occurrence of depression in patients with psoriasis - the role of inflammation, stress and mechanism of the vicious circle
    Autorzy:
    Kuchnicka, A.A.
    Zielinska, M.
    Kosz, K.
    Zarankiewicz, N.
    Piecewicz-Szczesna, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/2097852.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    psoriasis
    depression
    inflammatory disease
    skin disease
    inflammation
    Opis:
    Introduction. Psoriasis is a chronic skin disease which can have a detrimental impact on the patient’s life. The correlation between depression, psoriasis and inflammation is a subject of many publications. The depressive and psoriatic symptoms, unhealthy coping strategies and stigmatization might be presented in the mechanism of the vicious circle. The appropriate understanding of this phenomenon might be extremely useful for specialists to improve their bedside manner. Objective. The aim of this review is to analyze the current data about the worldwide presence of the major depressive disorder – psoriasis, and the occurrence of depression in patients suffering from psoriasis. Research and analysis were based on searching sources such as PubMed, UpToDate and World Health Organization pages for the integrative publications collected mainly from last 10 years. The data about the origin of the psoriasis disease was taken from as 1979 publication. State of knowledge. The study demonstrated that the link between psoriasis and depression is bi-directional. The pro- inflammatory cytokine, such as IL-6, TNF-α, CRP and IL-17, are elevated in both cases, which provokes the exacerbation of sickness symptoms. The inflammation dangerously disturbs the functioning of neuronal system and human homeostasis. Summary. According to the cited research, the prevalence of depressive disorders in psoriatic patients is higher in comparison to people without psoriasis. Inflammation plays an essential role by being a peculiar connector between psoriasis and depression. Stress and inflammation are crucial factors in pathogenesis of those two disorders and triggers the pathological mechanisms.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2020, 14, 2; 58-61
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Atopic eczema: genetics or environment?
    Autorzy:
    Wuthrich, B
    Cozzio, A.
    Roll, A.
    Senti, G.
    Kundig, T.
    Schmid-Grendelmeier, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/49593.pdf
    Data publikacji:
    2007
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    inflammatory skin disease
    environmental factor
    food
    atopy patch test
    non-atopic eczema
    Staphylococcus aureus
    contact allergen
    chronic disease
    human disease
    genetic condition
    therapy
    Malassezia sympodialis
    skin disease
    immunological deviation
    atopic eczema
    skin structure
    skin infection
    skin barrier
    Opis:
    Atopic eczema (AE) is a multifactorial skin disease caused by a variety of factors such as genetic conditions, alterated skin structure, immunologic deviations and environmental factors, among others. There are two main subtypes of AE, i.e. the IgE-associated (“atopic eczema”) and the non-IgE-associated type (“nonatopic eczema”) with different prognosis concerning the development of respiratory diseases (“atopy march”). Recently, it was demonstrated that Filaggrin (= fi lament-aggregating protein, FL) is a major gene for atopic eczema. Filaggrin binds to and aggregates the keratin cytoskeleton in the epidermis. Homozygous FLG mutation leads to complete loss of fi laggrin expression in skin. Half or more of children with moderate to severe AE carry FLG mutations. Moreover, fi laggrin loss-of-function mutations predispose to phenotypes involved in the atopy march. The altered skin structure and a defi ciency in antimicrobial peptides favour colonization with Staphylococcus aureus and yeasts (Malassezia sp.). Sensitization to the yeast occurs almost exclusively in AE patients. S. aureus enterotoxins with superantigenic activity stimulate activation of T cells and macrophages. So far, AE skin lesions are orchestrated by the local tissue expression of proinfl ammatory cytokines and chemokines with activation of T lymphocytes, dendritic cells, macrophages, keratinocytes, mast cells, and eosinophils which lead to the skin infl ammatory responses. From the therapeutic point of view, besides emollients and local corticosteroids, topic immunomodulatory drugs (tacrolimus and pimecrolimus) have substantially improved the treatment of AE.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2007, 14, 2
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Risk factors for work-related eczema and urticaria among vocational students of agriculture
    Autorzy:
    Śpiewak, Radosław
    Góra-Florek, Anna
    Horoch, Andrzej
    Jarosz, Mirosław J.
    Doryńska, Agnieszka
    Golec, Marcin
    Dutkiewicz, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/987044.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    work-related dermatoses
    occupational skin disease
    risk factors
    farmers
    agriculture
    vocational schools
    apprentices
    eczema
    dermatitis
    urticaria
    Opis:
    Introduction and objective. Farmers are at high risk of occupational skin diseases which may start already during vocational training. This study was aimed at identification of risk factors for work-related skin diseases among vocational students of agriculture. Materials and method. The study involved 440 students (245 males, 195 females aged 17–21 years) in 11 vocational schools which were at least 100 km from each other. The protocol included a physician-managed questionnaire and medical examination, skin prick tests, patch tests, total IgE and Phadiatop. Logistic regression model was used for the identification of relevant risk factors. Results. Work-related dermatoses were diagnosed in 29 study participants (6.6%, 95%CI: 4.3–8.9%): eczema in 22, urticaria in 14, and co-existence of both in 7 students. Significant risk factors for work-related eczema were: history of respiratory allergy (OR=10.10; p<0.001), history of eczema (itchy rash) provoked by wet work and detergents before entering the school (OR=5.85; p<0.001), as well as history of contact dermatitis to metals, rubber or cosmetics prior to inscription (OR=2.84; p=0.016), and family history of any skin disease (OR=2.99; p=0.013). Significant risk factors for work-related urticaria were: history of allergic rhinitis and asthma prior to inscription (OR=7.29; p=0.006), positive skin prick tests to work place allergens (OR=4.65; p=0.002) and to environmental allergens (OR=3.79; p=0.009), and positive Phadiatop test (OR=3.61; p=0.013). Conclusions. Work-related skin diseases are common among vocational students of agriculture. Atopy, past history of asthma, allergic rhinitis, and eczema (either atopic, allergic or irritant) are relevant risk factors for work-related eczema and urticaria in young farmers, along with family history of any skin disease. Positive skin prick tests seem relevant, especially in the case of urticaria. Asking simple, aimed questions during health checks while enrolling students into agricultural schools would suffice to identify students at risk for work-related eczema and urticaria, giving them the chance for selecting a safer profession, and hopefully avoiding an occupational disease in the future.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2017, 24, 4
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Hobnail hemangioma of the skin in a juvenile patient
    Autorzy:
    Ostrowska, A.
    Golonka, A.
    Bojar, P.
    Pasnik, I.
    Szumilo, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/3353.pdf
    Data publikacji:
    2015
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    hobnail hemangioma
    skin
    juvenile
    patient
    human disease
    hobnail cell
    vascular malformation
    vascular neoplasm
    Opis:
    Hobnail hemangioma is a rare, benign, vascular lesion with peculiar but commonly misleading morphology, located mostly on the extremities or trunk, and affects young and middle-aged adults with a slightly male predominance. A new typical case in a 17-year-old girl is presented. A single, small, painless skin lesion appeared in an early childhood on the lateral part of the right thigh, and was linked with scratching a previous pigmented lesion. Microscopic examination of the completely removed lesion revealed typical morphology. Prominent endothelial cells were podoplanin-negative and CD34-positive. There was no recurrence after four years follow-up.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2015, 09, 1
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Anti-cancer effect of betulin and its derivatives, with particular emphasis on the treatment of melanoma
    Autorzy:
    Cabaj, J.
    Bak, W.
    Wroblewska-Luczka, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/2098520.pdf
    Data publikacji:
    2021
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    neoplastic disease
    melanoma
    skin cancer
    cancer therapy
    anticancer effect
    triterpene
    betulin
    betulic acid
    Opis:
    Introduction. Neoplastic diseases are a common cause of death, especially in developed countries. Various methods are used in cancer therapy including natural substances. Terpenes and terpenoids play a special role, including betulin and betulinic acid with the pentacyclic structure of lupane. They have a wide range of pharmacological activity, among which anti-cancer activity attracts the greatest attention. Abbreviated description of the state of knowledge. The review discusses the pharmacological effects of betulin and its derivatives on tumours, and focuses on the potential of its application in the treatment of melanoma. The review study also presents future prospects for the use of this natural substance. Betulin and its derivatives have the ability to influence the processes of apoptosis, angiogenesis and autophagy. Additionally, they have the ability to sensitize, increasing the sensitivity to commonly used methods of cancer treatment. To-date, numerous studies have been carried out on the synthesis of betulinic acid derivatives, which would show greater polarity and activity compared to the starting compound. Due to their greater bioavailability, the modified compounds showed a stronger anti-tumour effect. Conclusion. The results of the above-mentioned studies confirm the anti-cancer properties of betulin. Regarding melanoma, betulin shows significant therapeutic efficacy. This gives new perspectives for the treatment of the most dangerous skin cancer.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2021, 15, 2; 73-79
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Regional importance of Alnus pollen as an aeroallergen: a comparative study of Alnus pollen counts from Worcester [UK] and Poznan [Poland]
    Autorzy:
    Smith, M
    Emberlin, J.
    Stach, A.
    Czarnecka-Operacz, M.
    Jenerowicz, D.
    Silny, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/50630.pdf
    Data publikacji:
    2007
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    Worcester
    human disease
    pollen
    pollen grain
    skin risk test
    allergy
    Poznan city
    Europe
    Alnus
    allergen
    Opis:
    Daily average Alnus pollen counts (1996-2005) from Worcester (UK) and Poznań (Poland) were examined with the aim of assessing the regional importance of Alnus pollen as an aeroallergen. The average number of Alnus pollen grains recorded annually at Poznań was more than 2.5 times that of Worcester. Furthermore, daily average Alnus pollen counts exceeded the thresholds of 100, 500 and 1,000 grains/m3 more times at Poznań than Worcester. Skin prick test results (1996-2005) and allergen-specifi c IgE (asIgE) measurements using the CAP (Pharmacia) system (2002-2005), were supplied by the Allergic Diseases Diagnostic Centre in Poznań. The annual number of positive skin prick tests to Alnus pollen allergens was signifi cantly related (p<0.05) to seasonal variations in the magnitude of the Alnus pollen catch recorded at Poznań (r=0.70). The symptoms of patients with positive skin prick tests to Alnus pollen allergens were: 51% pollinosis, 43% atopic dermatitis, 4% asthma, 1% chronic urticaria and 1% eczema. On a scale of 0-6, 20.5% of patients examined for serum asIgE in relation to Alnus pollen allergens had asIgE measurements in classes 5 and 6. Alnus pollen is generally considered to be mildly allergenic. However, the amount of Alnus pollen released into the atmosphere in places such as Poznań may increase its impact on the population and make it one of the more important aeroallergens present.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2007, 14, 1
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Meteorological and agricultural effects on airborne Alternaria and Cladosporium spores and clinical aspects in Valladolid [Spain]
    Autorzy:
    Reyes, E S
    de la Cruz, D.R.
    Merino, E.S.
    Sanchez, J.S.
    Powiązania:
    https://bibliotekanauki.pl/articles/51010.pdf
    Data publikacji:
    2009
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    Alternaria
    Cladosporium
    spore
    meteorological effect
    agricultural effect
    maximum concentration
    temperature
    skin test reaction
    clinical aspect
    Spain
    allergy
    human disease
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2009, 16, 1; 53-61
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A novel inhalation challenge set to study animal model of allergic alveolitis
    Autorzy:
    Golec, M
    Skorska, C.
    Lemieszek, M.
    Dutkiewicz, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/52160.pdf
    Data publikacji:
    2009
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    inhalation challenge
    allergic alveolitis
    animal model
    mice
    mouse
    bioaerosol
    organic dust
    dust
    microbial allergen
    Pantoea agglomerans
    dust exposure
    human disease
    respiratory tract
    skin
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2009, 16, 1; 173-175
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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