Temat: melanoma - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: A review of selected natural phytochemicals in preventing and treating malignant skin neoplasms
Autorzy:: Fruman-Toczek, Dominika
Zagórska-Dziok, Martyna
Dudra-Jastrzębska, Monika
Kruszewski, Marcin
Kapka-Skrzypczak, Lucyna
Powiązania:: https://bibliotekanauki.pl/articles/972368.pdf
Data publikacji:: 2016
Wydawca:: Instytut Medycyny Wsi
Tematy:: nonmelanoma skin cancer
malignant melanoma
phytochemicals
carotenoids
terpenoids
flavonoids
Opis:: Malignant skin neoplasms are one of the most common human malignancies. The incidence of nonmelanoma skin cancers and malignant melanoma is constantly increasing. The current therapies, especially for malignant melanoma, have relatively low success rates. Therefore, there is an urgent need to develop new remedies that are both safe and effective. Natural substances have always been an important source for the discovery of new therapies. In turn, a number of studies have indicated that some phytocheicals could have an anti-tumour effect. In vitro and in vivo testing of malignant skin neoplasm models revealed different anti-tumour actions, including antioxidation, carcinogen inactivation, anti-proliferation, cell cycle arrest, induction of apoptosis, inhibition of angiogenesis, or a combination of them. The aim of this paper is to describe anti-tumour compounds derived from natural sources that might be used in the therapy of malignant skin neoplasm. The phytochemicals discussed below include carotenoids, terpenoids and flavonoids.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2016, 10, 2; 127-130
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Anti-cancer effect of betulin and its derivatives, with particular emphasis on the treatment of melanoma
Autorzy:: Cabaj, J.
Bak, W.
Wroblewska-Luczka, P.
Powiązania:: https://bibliotekanauki.pl/articles/2098520.pdf
Data publikacji:: 2021
Wydawca:: Instytut Medycyny Wsi
Tematy:: neoplastic disease
melanoma
skin cancer
cancer therapy
anticancer effect
triterpene
betulin
betulic acid
Opis:: Introduction. Neoplastic diseases are a common cause of death, especially in developed countries. Various methods are used in cancer therapy including natural substances. Terpenes and terpenoids play a special role, including betulin and betulinic acid with the pentacyclic structure of lupane. They have a wide range of pharmacological activity, among which anti-cancer activity attracts the greatest attention. Abbreviated description of the state of knowledge. The review discusses the pharmacological effects of betulin and its derivatives on tumours, and focuses on the potential of its application in the treatment of melanoma. The review study also presents future prospects for the use of this natural substance. Betulin and its derivatives have the ability to influence the processes of apoptosis, angiogenesis and autophagy. Additionally, they have the ability to sensitize, increasing the sensitivity to commonly used methods of cancer treatment. To-date, numerous studies have been carried out on the synthesis of betulinic acid derivatives, which would show greater polarity and activity compared to the starting compound. Due to their greater bioavailability, the modified compounds showed a stronger anti-tumour effect. Conclusion. The results of the above-mentioned studies confirm the anti-cancer properties of betulin. Regarding melanoma, betulin shows significant therapeutic efficacy. This gives new perspectives for the treatment of the most dangerous skin cancer.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2021, 15, 2; 73-79
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Molecular and environmental aspects of skin cancers
Autorzy:: Zebracka, A.
Matysiak, M.
Dudra-Jastrzebska, M.
Kapka-Skrzypczak, L.
Powiązania:: https://bibliotekanauki.pl/articles/3509.pdf
Data publikacji:: 2015
Wydawca:: Instytut Medycyny Wsi
Tematy:: molecular aspect
environmental aspect
skin
cancer
malignant melanoma
basal cell carcinoma
squamous cell carcinoma
ultraviolet radiation
carcinogenesis
Opis:: Skin cancers are one of the most common cancers in the Caucasian population. A constantly increasing number of nonmelanoma skin cancers and malignant melanomas is observed. The incidence of skin cancers is associated mainly with exposure to sunlight. Therefore, agricultural workers who work in open spaces are a particularly vulnerable group. Currently, studies on the pathogenesis of skin cancer focus on the molecular basis associated with ultraviolet radiation. This study is an attempt to summarize the current state of knowledge on this issue. There have been demonstrated mutations in different classes of genes associated with carcinogenesis, including protooncogenes, tumour suppressor genes, genes that control apoptosis, genes encoding transcription factors and DNA repair genes in patients with skin cancers. Mutations in the latter result in reducing the effectiveness of DNA repair and fixation of mutations. All changes at the gene level lead to structural changes, quantitative and dysfunction of proteins encoded by these genes. All these factors contribute to the process of carcinogenesis. Due to increasing number of skin cancers, it seems important to increase knowledge of the molecular basis of skin cancers. This knowledge could be crucial for predicting the course of the disease, and for the development of new therapeutic strategies.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2015, 09, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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