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    Wyświetlanie 1-6 z 6
    Tytuł:
    Wpływ radioaktywnego radonu i jego pochodnych na zdrowie człowieka
    The impact of radioactive radon and its decay products on human health
    Autorzy:
    Bilska, Izabela
    Powiązania:
    https://bibliotekanauki.pl/articles/1035600.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    "health risks"
    "ionizing radiation"
    "radon"
    Opis:
    Ionizing radiation derived from radon isotopes and their derivatives is responsible for approx. 40% of the annual dose that every human being takes from all sources of radiation. These are alpha-emitting isotopes, which is important in terms of human health harms. In the article, the sources of radioactive radon entering the air in residential rooms are presented. It also shows the mechanism of forming its derivatives and their impact on human health. Moreover, it provides a list of diseases which these substances can trigger or stimulate and enumerates their medical, beneficial uses. In order to differentiate between positive and negative effects of radon on human body, the article brings together recommendations of international organizations and Polish legal norms.
    Promieniowanie jonizujące pochodzące od izotopów radonu i ich pochodnych jest odpowiedzialne za ok. 40% dawki rocznej, jaką przyjmuje człowiek ze wszystkich źródeł promieniowania. Są to izotopy alfa-promieniotwórcze, co ma istotne znaczenie w aspekcie szkodliwości dla zdrowia człowieka. W artykule oprócz źródeł przedostawania się radioaktywnego radonu do powietrza w pomieszczeniach, przedstawiono mechanizm powstawania jego pochodnych i sposób oddziaływania tych substancji na zdrowie ludzi. Wymieniono schorzenia, do powstawania i rozwoju których przyczyniają się omawiane substancje oraz przedstawiono przykłady leczniczego ich zastosowania. Aby rozgraniczyć pozytywny i negatywny wpływ radonu na organizm człowieka podano zalecenia organizacji międzynarodowych i normatywy prawne obowiązujące w Polsce i na świecie.
    Źródło:
    Medycyna Środowiskowa - Environmental Medicine; 2016, 19, 1; 51-56
    1505-7054
    2084-6312
    Pojawia się w:
    Medycyna Środowiskowa - Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of ionizing radiation on the female reproductive system
    Autorzy:
    Skrzypek, M.
    Wdowiak, A.
    Panasiuk, L.
    Stec, M.
    Szczygieł, K.
    Zybała, M.
    Filip, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085209.pdf
    Data publikacji:
    2019
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    infertility
    ionizing radiation
    female reproductive health
    gonadotoxic action
    Opis:
    Introduction and objective. The tendency towards postponement of maternity implies a greater exposure of female germ cells to damaging environmental effects, including ionizing radiation (IR). Progress in paediatric oncology, based on the use of radiotherapy, also implies the occurrence of gonadal dysfunctions and subsequent female fertility disorders. Therefore, it seems justifiable to systematize the state of knowledge concerning the effect of IR on the female reproductive system. Brief description of the state of knowledge. A considerable part of studies concerning the effect of IR on female germ cells have been conducted on animals. Their extrapolation to humans is hindered because in animal studies high acute exposures are applied, which do not reflect human environmental exposures characterized by chronic low dose exposure. Studies on animals provide a heterogenous image, which hinders the formulation of unequivocal conclusions and indicates that radiosensitivity depends, i.a. on IR dose, stage of development of oocytes, the applied marker of the effects of IR, or on the species. LD50 of human oocytes is estimated to be below 2 Gy. The effect of IR depends, i.a. on the dose fractionation and the age (older women are more radiosensitive). In females, the effective sterilizing dose is: at birth 20.3 Gy, at 10 years 18.4 Gy, at 20 years 16.5 Gy, whereas at 30 years 14.3 Gy, which is associated with the available pool of ovarian follicles. Conclusions. Within the range of low doses received as a result of environmental exposure to IR, there is no evidence for the occurrence of either adverse pregnancy outcomes, nor fertility disorders in females. These effects may be related to the cancer radiotherapy, or exposure to high IR doses during nuclear accidents.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2019, 26, 4; 606-616
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Background ionizing radiation and semen parameters of men with reproductive problems
    Autorzy:
    Wdowiak, A.
    Stec, M.
    Raczkiewicz, D.
    Bień, A.
    Iwanowicz-Palus, G.
    Panasiuk, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085376.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    ionizing radiation
    men
    semen analysis
    sperm quality
    reproduction
    male infertility
    Opis:
    Introduction and objective. The male reproductive system constitutes a set of tissues which are particularly sensitive to external factors. The aim of the study was to analyze the relationship between background radioactivity and the quality of the semen of the men who have reported to the infertility treatment facility in 2000–2016 in the Lublin region of eastern Poland. Materials and method. The radioactivity of the ground-level air layer obtained from the Institute of Meteorology and Water Management in Włodawa in the Lublin region was analysed. 4,250 spermiograms of patients who reported to the treatment facility for the first time due to infertility were analysed and correlated to background radioactivity in the Lublin region in 2000–2016. Results. A long-term decrease in the percentage of morphologically normal spermatozoa of the patients was observed (r=-0.970; p<0.001 in 2000–2009 and r=-0.925; p=0.003 in 2010–2016). Men’s age correlated negatively with sperm motility (r=-0.164; p=0.009) and morphology (r=-0.186; p=0.009). The percentage of spermatozoa with normal morphology was lowered by beta-isotopes of artificial origin in the air in 2000–2009 (r=-0.655; p=0.040) and by the exposure to gamma radiation of the ground-level atmosphere in 2010–2016 (r=-0.676; p=0.048). The percentage of sperm vitality was lowered by gamma radiation in the atmosphere (r=-0.636; p=0.006), but improved by beta isotopes in precipitation (r=0.686; p=0.002) in the whole of the analyzed period. Conclusions. The percentage of morphologically normal spermatozoa in patients who reported to the infertility treatment depends not only on the age of patient, but also on beta-isotopes of artificial origin and gamma radiation in the atmosphere. Beta isotopes in precipitation affect the improvement of sperm vitality.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2020, 27, 1; 43-48
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of ionizing radiation on the male reproductive system
    Autorzy:
    Wdowiak, A.
    Skrzypek, M.
    Stec, M.
    Panasiuk, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/2083104.pdf
    Data publikacji:
    2019
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    radiation protection
    ionizing radiation
    male fertility
    human reproductive function
    medical exposure
    natural exposure
    Opis:
    Introduction and objective. In the light of current data concerning the growing exposure to ionizing radiation (IR) originating from atrificial sources, especially from medical ones, and also related to occupational exposure, it is justifiable to systematize the state of knowledge concerning the effect of IR on the male reproductive system. Brief description of the state of knowledge. There is no basis for the application of the hypothesis of hormesis in the area of male reproductive health. Regarding the impact of IR on spermatogenesis, spermatogonia are less susceptible to the occurrence of DNA damage after exposition to IR, but are characterized by slower DNA repair compared to somatic cells. Damage to the genes after exposure to IR is possible at each stage of spermatogenesis; however, haploidal spermatids show the highest radiosensitivity in this respect. The genetic risk of the cells differentiating during spermatogenesis is limited to one cycle of spermatogenesis, whereas the genetic instability may persist for the whole period of life, and DNA damage induced by IR may be transmitted to future generations. The minimum dose causing detectable DNA damage was 30 Gy. While exceeding this dose, the number of single-strand DNA breaks increases. Among males exposed to IR, a decrease was observed in sperm motility and in the percentage of morphologically normal spermatozoa as well as in an intensification of vacuolization. The genetic material in the sperm of these males showed higher fragmentation and methylation of genomic DNA. Conclusion. In the context of the epidemiological situation concerning the prevalence of infertility, while assessing the health effects of exposure to IR from artificial, including medical sources, the reproductive risk should be considered.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2019, 26, 2; 210-216
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Expression of cellular isoform of prion protein on the surface of peripheral blood lymphocytes among women exposed to low doses of ionizing radiation
    Autorzy:
    Klucinski, P
    Mazur, B.
    Hrycek, A.
    Masluch, E.
    Cieslik, P.
    Kaufman, J.
    Martirosian, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/50336.pdf
    Data publikacji:
    2007
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    blood lymphocyte
    ionizing radiation
    low dose
    lymphocyte
    cellular isoform
    woman
    radiation exposure
    expression
    prion protein
    Opis:
    Ionizing radiation affects the expression of adhesive and co-stimulatory molecules in lymphocytes. The physiological function of cellular isoform of prion protein (PrPc) is little known. Evidences indicate a link between lymphocytes activation and PrPc expression on their surface; however, no direct effect of radiation on PrPc level in these cells was investigated. The objective of this study was to determinate the effect of low doses of ionizing radiation on the expression of PrPc on the surface peripheral blood lymphocytes in the women operating X-ray equipment. In 36 female workers and 30 persons of the control group the PrPc expression on CD3 (T lymphocytes), CD4 (T helper), CD8 (T cytotoxic) and CD19 (B lymphocytes), as well as the percentage of lymphocytes with PrPc on their surface, were tested. Subgroups with respect to age and length of employment were selected. A signifi cant increase was observed in PrPc expression on CD3 and CD4 with lowered PrPc level on CD8 and percentage of CD8 cells with PrPc in workers compared to control. The PrPc level did not show signifi cant changes in subgroups in relation to age (below and over 40 years old) both in the investigated and control groups, whereas a lower percentage of PrPc expressing CD19 cells showed in employed women below 40 years of age. A signifi cant decrease was found in PrPc expression on the surface of CD3, CD4 and CD8 cells in the subgroup employed for over 10 years than in the subgroup with less than 10 years of employment.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2007, 14, 2
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Searching for in vitro biomarkers of susceptibility to prostate and cervical cancers by analysis of chromosomal instability, gamma-H2AX foci, polymorphisms in DNA repair genes and apoptosis
    Autorzy:
    Wegierek-Ciuk, A.
    Arabski, M.
    Kedzierawski, P.
    Florek, A.
    Solowiej, D.
    Gozdz, S.
    Lisowska, H.
    Kowalik, A.
    Kowalska, M.
    Wojcik, A.
    Polanska, J.
    Lankoff, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/3629.pdf
    Data publikacji:
    2015
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    in vitro biomarker
    susceptibility
    prostate
    cervical cancer
    cancer
    patient
    human disease
    lymphocyte
    man
    ionizing radiation
    chromosome instability
    gamma-H2AX biomarker
    polymorphism
    DNA repair gene
    apoptosis
    Opis:
    Introduction and objective. According to the cancer epidemiology databases, cancer is the second leading cause of death in developing countries. Moreover, the WHO predicts a continuing increase in the incidence of cancer, extending this trend well into the next several decades. Hence, it seems obvious that the prediction of cancer susceptibility and early diagnosis is an important goal for modern biomedical sciences. The aim of this study is to clarify the value of chromosomal damage, capacity for the repair of double-strand breaks (DSBs), polymorphisms in DNA repair genes, and apoptosis as prognostic markers for prostate and cervical cancer. Materials and methods. 30 prostate cancer patients and 30 cervical cancer patients were enrolled into the study. In addition, 30 healthy female donors and 30 healthy male donors served as controls. The following endpoints were investigated: frequency of micronuclei, gamma-H2AX fluorescence, XRCC1 194C>T, XRCC1 399G>A, XRCC3 IVS5–14 A>G, OGG1 326 Ser>Cys polymorphisms and apoptosis. Results. Among all tested factors, only the homozygous variant (Arg/Arg) in XRCC1 (399 Arg/Gln) was strongly associated with prostate cancer risk, and only a low apoptotic response was connected with cervical cancer risk. The presented study confirmed a positive association between the frequency of MN and increased prostate and cervical cancer risk. However, such a biomarker is not cancer specific. In addition, the information gained by analyzing the gamma-H2AX fluorescence, as well apoptosis, had no value for predicting the risk of prostate and cervical cancers. Conclusions. The final conclusion of the study is that cancer susceptibility is a complex phenotype not readily detectable in relatively small studies by functional assays or analysis of SNP in few, selected genes.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2015, 09, 2
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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