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    Wyświetlanie 1-3 z 3
    Tytuł:
    Ventilator-associated pneumonia (VAP) caused by Acinetobacter baumannii in view of the microbial properties of the ESKAPE group in neighbouring countries - Poland and Ukraine
    Autorzy:
    Grochowalska, Aneta
    Kozioł-Montewka, Maria
    Oliynyk, Oleksandr
    Krasij, Natalia
    Powiązania:
    https://bibliotekanauki.pl/articles/972522.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    resistance to antibiotics
    VAP
    ESKAPE
    Acinetobacter baumannii
    Opis:
    The increase in the clinical threat of ESKAPE pathogens is associated with high virulence and the presence of numerous mechanisms of antimicrobial resistance. The above characteristics of pathogens affect therapeutic failures as well as cause prolongation and increase of the cost of its treatment. Objective. The aim of this study was to evaluate and analyze Acinetobacter baumannii strains in relation to the remaining bacteria from the ESKAPE group that induced pneumonia in mechanically ventilated patients in two neighboring countries. Materials and method. The study was retrospective. 335 clinical materials were analyzed, mainly bronchoalveolar lavage gained for microbiological screen. The analyzed patients were in intensive care units (ICU) in selected hospitals in 2013 –2015, in Poland (154 patients) and in Ukraine (181 patients). Results. In the analysis of etiological agents of VAP caused by ESKAPE strains, Gram negative bacteria were predominant in both countries although particular species occurred at different frequencies in Poland and Ukraine. Multi-resistant strains of Acinetobacter baumannii were more frequently cultured from patients in Poland (26.9%) compared to those from Ukraine (14.6%).
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2017, 11, 2; 111-115
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of Acinetobacter baumannii resistance patterns in patients with chronic obstructive pulmonary disease (COPD) in terms of choice of effective empiric antibiotic therapy
    Autorzy:
    Grochowalska, Aneta
    Kozioł-Montewka, Maria
    Sobieszczańska, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/989765.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    copd
    antibiotics
    acinetobacter baumannii
    multidrug-resistant strains
    co-infection
    Opis:
    Introduction. Multi-resistant Acinetobacter baumannii isolated from patients has become one of the most hazardous pathogens in health care settings. The aim of the study was to analyze pneumonia caused by Acinetobacter baumannii in patients hospitalized because of exacerbation of chronic obstructive pulmonary diseases (COPD), who were admitted to the Pulmonology Ward of the Masovian Specialistic Hospital in Radom (MSS). The incidence and drug sensitivity of these non-fermenting rods were evaluated, and compliance with antimicrobial procedure with the algorithm of the guidelines in applicable recommendations, was estimated. This should result in determining the local patterns of resistance and verifying therapeutic procedures in accordance with the assumptions of hospital antibiotic policy. In addition, the study examined the effectiveness of empiric and targeted therapy according to the clinical condition of the patient, and the eradication of A. baumannii, in comparison with the aggravating factors of the patient. Materials and Method. The retrospective study included 90 patients with exacerbation of COPD whose etiological factor of infection was A. baumannii, hospitalized in the Department of Pulmonology (MSS) in 2012–2016. Results. Studies were conducted on 90 patients with COPD exacerbation from which A. baumannii was isolated. Co-infections with other bacterial species among 41 patients were additionally noted. The majority of A. baumannii strains showed a high resistance (90%) to fluoroquinolones, ceftazidime, piperacillin/tazobactam. For strains causing a co-infection, drug resistance was successively 44–56%, 44%, 44%. All of patients received empirical therapy. The most commonly used drug was amoxicillin with a clavulanic acid, often combined with fluoroquinolone. This type of therapy was effective among 10% of patients. The mortality in this group was determined at 29%. Among 79% of patients with COPD, a targeted therapy was performed which proved to be effective in 58% of treated cases by susceptibility testing. The highest efficacy was observer after the use of colistin and carbapenems. Conclusion. In the performed study, the infections caused by multi-resistant Acinetobacter baumannii, were observed in COPD, which should be taken into consideration in choosing empirical antibiotic therapy. Simultaneously, the local resistance patterns of multi-drug-resistant (MDR) Gram-negative strains co-infecting COPD should be considered in empirical treatment. Moreover, both additional clinical complication and co-infections contribute to a more severe course of diseases. In this study, the mortality percent exceeded 29%.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2017, 24, 2
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Resistance to the tetracyclines and macrolidelincosamide-streptogramin group of antibiotics and its genetic linkage - a review
    Autorzy:
    Marosevic, Durdica
    Kaevska, Marija
    Jaglic, Zoran
    Powiązania:
    https://bibliotekanauki.pl/articles/989867.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    antibiotics
    genetic determinants of resistance
    transposons
    transmission of resistance
    Opis:
    An excessive use of antimicrobial agents poses a risk for the selection of resistant bacteria. Of particular interest are antibiotics that have large consumption rates in both veterinary and human medicine, such as the tetracyclines and macrolidelincosamide-streptogramin (MLS) group of antibiotics. A high load of these agents increases the risk of transmission of resistant bacteria and/or resistance determinants to humans, leading to a subsequent therapeutic failure. An increasing incidence of bacteria resistant to both tetracyclines and MLS antibiotics has been recently observed. This review summarizes the current knowledge on different tetracycline and MLS resistance genes that can be linked together on transposable elements.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2017, 24, 2
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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