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    Wyświetlanie 1-2 z 2
    Tytuł:
    Nesfatin-1 prevents negative changes in bone in conditions of developing osteopenia
    Autorzy:
    Puzio, I.
    Tymicki, G.
    Pawłowska, M.
    Bieńko, M.
    Radzki, R.P.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085429.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    nesfatin-1
    osteopenia
    osteoporosis
    ovariectomy
    rat
    DXA
    pQCT
    immunohistochemistry
    Opis:
    Objective. The aim of the study was to determine the effect of nesfatin-1 on bone properties in female rats in the conditions of developing osteopenia induced by ovariectomy (OVX). Materials and method. The experiment was performed on 21 female Wistar rats assigned to 3 groups receiving intraperitoneally physiological saline (SHO, OVX-PhS) and nesfatin-1 in dose 2 μg/kg BW of (OVX-NES) once a day for 8 wks. At the end of the experiment, the rats were scanned using the DXA method to determine the body composition, tBMC, and tBMD. The isolated femora and tibia were tested with the DXA method for BMD and BMC, and with the pQCT method for separate analysis of the cortical and trabecular bone tissue. The bone strength parameters were also determined. The immunohistochemical method was used for determination of nesfatin-1 localization in growth cartilage. Bone metabolism markers (osteocalcin, bALP, and NTx) were identified using an ELISA kit. Results. OVX exerts a negative effect on bone tissue. The nesfatin-1 administration influenced positively the DXA parameters of tibia. TvBMD and TbvBMD measured by pQCT in metaphysis of bones were significantly higher in the OVX-NES group than in OVX-PhS. No differences were found in the values of bone strength parameters between SHO and OVX-NES females. Extra- and intracellular immunohistochemical reaction for nesfatin-1 was observed in all zones of growth cartilage, with the strongest reaction detected in the calcifying zone. Nesfatin-1 administration caused a significant increase in the osteocalcin and bALP concentration in relation to the OVX-PhS animals. Conclusion. The results of the experiment indicate that nesfatin-1 exerts a protective effect on bone tissue properties and can be used in the prevention of osteoporosis.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2020, 27, 1; 66-75
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Symptoms of selected parasitic diseases in the oral cavity
    Autorzy:
    Puzio, N.
    Sikora, M.
    Srebrna, A.
    Straczek, A.
    Weglarz, N.
    Lewandowska, K.
    Mazurek, G.
    Thum-Tyzo, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/2098260.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    oral cavity
    parasitic disease
    protozoan disease
    nematode
    helminth
    arthropod
    parasitosis
    periodontitis
    Opis:
    Introduction. Parasitic diseases are caused by many species of protozoa, helminths, and arthropods. Parasitosis can be divided into gastrointestinal, tissue and skin diseases and can appear in many different parts of the body. The most common route of transmission is via ingestion. The oral cavity may be a place of colonization for pathogens, resulting in lesion formation. Objective. The aim of the study is to characterise and describe the most important symptoms of parasitic diseases that can be diagnosed during dental examination. Abbreviated description of the state of knowledge. In this study there are discussed diseases caused by the most common protozoa and the nematodes in the oral cavity. Leishmaniasis is caused by Leishmania spp. protozoa, and its most common symptom observed in the oral cavity are painful ulcerations. Toxoplasmosis usually manifests itself through enlargement of the lymph nodes, and the appearance of antibodies in saliva. Entamoeba gingivalis and Trichomonas tenax cause periodontitis chronica and inflammation of the soft tissue. The first of the nematodes, Gongylonema pulchrum, is the reason for, among others, the itchy sensation of a moving foreign body under the mucosa. The most common symptoms of Ancylostoma infection are erythematous papules. Filariae causes an infection that manifests through swelling, abscesses, and painless nodules inside the mouth. Conclusions. New pathogens are emerging worldwide and pose a threat to health. They can manifest their symptoms in the oral cavity, but the diagnosis of the disease by the dentist is not easy and requires interdisciplinary knowledge and consultation.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2021, 15, 1
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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