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Wyświetlanie 1-3 z 3
Tytuł:
Periodontal status of patients aged 18 living in the Lublin Province of eastern Poland
Autorzy:
Trubecka-Posnik, Ewa
Tymczyna, Barbara
Haratym-Maj, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/972718.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
periodontal status
risk factors
young adults
CPI index
Opis:
Introduction and Objective. Periodontitis is the one of most common chronic inflammatory diseases of the oral cavity. Periodontal disease (PD) concerns mainly adults; however, it is now increasingly seen in adolescents. The mechanism responsible for the higher prevalence of periodontal among young adults may be associated with the changes in lifestyle. Awareness of the role of proper oral hygiene and a healthy lifestyle is therefore essential for the prevention of periodontal disease in young people. The aim of the study was to assess the prevalence and severity of periodontal disease among 18-year-old young adults from Lublin Province in eastern Poland. Materials and method. The study group included 75 adolescents aged 18 years – 50 urban and 25 rural. Periodontal status was assessed on the basis of the CPI (Community Periodontal Index). Results. The results obtained showed that clinically healthy periodontium was found only in 26.66% of the study population. 73.34% of adolescents had periodontal problems. Healthy periodontium was observed more frequently among rural residents than among urban residents. Conclusions. The data show that 73.4% of young adults needs to take preventive or treatment actions for periodontal diseases. It could be used as a marker for an increased risk of PD in adults.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2017, 11, 1; 35-37
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Endocannabinoid system and cannabinoids in neurogenesis - new opportunities for neurological treatment? Reports from experimental studies
Autorzy:
Drab, Aleksandra
Zagaja, Mirosław
Haratym-Maj, Agnieszka
Łuszczki, Jarogniew Jacek
Andres-Mach, Marta
Powiązania:
https://bibliotekanauki.pl/articles/972633.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
neurogenesis
cannabinoids
endocannabinoid system
Opis:
Neurogenesis is one of the most important phenomenona affecting human life. This process consists of proliferation, migration and differentiation of neuroblasts and synaptic integrations of newborn neurons. Proliferation of new cells continues into old age, also in humans, although the most extensive process of cell formation occurs during the prenatal period. It is possible to distinguish two regions in the brain responsible for neurogenesis: the dentate gyrus (DG) of the hippocampus and the sub-ventricular zone (SVZ). Hippocampal neurogenesis is very sensitive to various physiological and pathological stimuli. The functional integration of the newly-born dentate granule cells into hippocampal circuitry, and their ability to mediate long-term potentiation in DG, has led to the hypothesis that neurogenesis in the adult brain may play a key role in learning and memory function, as well as cognitive dysfunction in some diseases. Brain disorders, such as neurodegenerative diseases or traumatic brain injuries, significantly affect migration, proliferation and differentiation of neural cells. In searching for the best neurological drugs protecting neuronal cells, stimulating neurogenesis, while also developing no side-effects, endocannabinoids proved to be a strong group of substances having many beneficial properties. Therefore, the latest data is reviewed of the various experimental studies concerning the analysis of the most commonly studied cannabinoids and their impact on neurogenesis.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2017, 11, 1; 76-80
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Increased neurogenesis after ACEA and levetiracetam treatment in mouse pilocarpine model of epilepsy
Autorzy:
Zagaja, Mirosław
Szewczyk, Aleksandra
Haratym-Maj, Agnieszka
Rola, Radosław
Maj, Maciej
Łuszczki, Jarogniew J.
Anders-Mach, Marta
Powiązania:
https://bibliotekanauki.pl/articles/972512.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
neurogenesis
neurons
astrocytes
pilocarpine
ACEA
Levetiracetam
Opis:
Introduction and objectives. The aim of the study was to asses the impact of long-term therapy with the second generation antiepileptic drug levetiracetam (LEV) with arachidonyl-2’-chloroethylamide (ACEA), a highly selective cannabinoid CB1 receptor agoniston the process of neurogenesis in a mouse pilocarpine model of epilepsy (PILO). Additionally, a relationship was established between the treatment with ACEA in combination with LEV, and hippocampal neurogenesis in mouse PILO brain. Materials and method. All experiments were performed on adolescent male CB57/BL mice injected i.p. with LEV (10 mg/kg), ACEA (10 mg/kg) and PMSF (30 mg/kg) (phenylmethylsulfonyl fluoride — a substance protecting ACEA against degradation by the fatty-acid amidohydrolase), pilocarpine (PILO, a single dose 290 mg/kg) and methylscopolamine (30 min before PILO to stop the peripheral cholinergic effects of the pilocarpine, 1 mg/kg). The process of neurogenesis was evaluated after10 days treatment with LEV and ACEA. Results. Obtained results indicated that the combinations of ACEA+PMSF+LEV and ACEA +PMSF increased the total number of total newborn cells compared to the control. Moreover, ACEA+PMSF administered alone and in combination with LEV had a significant impact on neurogenesis increasing the total number of newborn neurons compared to the control group. Neither LEV nor PMSF had a significant impact on the number of proliferating cells and newborn neurons when compared to the control PILO group. In turn, LEV administered alone decreased significantly the number of astrocytes. However, ACEA+PMSF has demonstrated significant increase of astrocytes compare to control mice. Conclusions. These data provide substantial evidence that the combination of LEV+ACEA significantly increases the level of newborn neurons in the PILO dentate subgranular zone.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2017, 11, 2; 136-141
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-3 z 3

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