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    Wyświetlanie 1-7 z 7
    Tytuł:
    Research on prevention and treatment of hemorrhagic fevers
    Autorzy:
    Joniec, J.
    Kolodziej, M.
    Bartoszcze, M.
    Kocik, J.
    Knap, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/52164.pdf
    Data publikacji:
    2012
    Wydawca:
    Instytut Medycyny Wsi
    Opis:
    Viral hemorrhagic fevers are severe zoonotic diseases caused by RNA-viruses classified into 4 families: Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae. They are present on all continents except Antarctica, their person-to-person spread is easy, and there is a high risk of them being used as weapon by bioterrorists. So far, efforts to develop effective drugs against these viruses have failed, and typical therapy usually relies on symptomatic treatment. Search for substances that could effectively inhibit this type of infections is now a priority. The presented paper gives an overview of different approaches used in combating the viral hemorrhagic fevers. Researchers look for safe antiviral agents with appropriate properties among natural sources, such as various types of herbs plants, algae, or essential oils obtained from trees, as well as investigate the use of various synthetic substances. The aim is to broaden the pool of available antiviral drugs that could replace hitherto applied medicines such as ribavirin, which is not always sufficiently effective and may have side-effects. The scientists focus not only on combating the diseases, but also on their prevention. For this purpose, recombinant vaccines or various types of immunomodulators may serve as a useful tools. Results of the latest studies are promising and encourage further work which may eventually lead to the solution of the urgent problem of hemorrhagic fevers.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2012, 19, 2
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Research on substances with activity against orthopoxviruses
    Autorzy:
    Kolodziej, M.
    Joniec, J.
    Bartoszcze, M.
    Gryko, R.
    Kocik, J.
    Knap, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/51870.pdf
    Data publikacji:
    2013
    Wydawca:
    Instytut Medycyny Wsi
    Opis:
    Although smallpox was eradicated over 30 years ago, the disease remains a major threat. High mortality, high infectivity and low resistance of the contemporary population make the smallpox virus very attractive to terrorists. The possible presence of illegal stocks of the virus or risk of deliberate genetic modifications cause serious concerns among experts. Hence, it is reasonable to seek effective drugs that could be used in case of smallpox outbreak. This paper reviews studies on compounds with proven in vitro or in vivo antipoxviruses potential, which show various mechanisms of action. Nucleoside analogues, such as cidofovir, can inhibit virus replication. Cidofovir derivatives are developed to improve the bioavailability of the drug. Among the nucleoside analogues under current investigation are: ANO (adenozine N1-oxide) and its derivatives, N-methanocarbothymidine [(N)-MCT], or derivatitives of aciklovir, peninclovir and brivudin. Recently, ST-246 – which effectively inhibits infection by limiting release of progeny virions – has become an object of attention. It has been also been demonstrated that compounds such as: nigericin, aptamers and peptides may have antiviral potential. An interesting strategy to fight infections was presented in experiments aimed at defining the role of individual genes (E3L, K3L or C6L) in the pathogenesis, and looking for their potential blockers. Additionally, among substances considered to be effective in the treatment of smallpox cases, there are factors that can block viral inhibitors of the human complement system, epidermal growth factor inhibitors or immunomodulators. Further studies on compounds with activity against poxviruses are necessary in order to broaden the pool of available means that could be used in the case of a new outbreak of smallpox.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2013, 20, 1
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of a child infected with Hymenolepis diminuta in Poland
    Autorzy:
    Kolodziej, P.
    Rzymowska, J.
    Stepien-Rukasz, H.
    Lorencowicz, R.
    Lucinska, M.
    Dziobek, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/50497.pdf
    Data publikacji:
    2014
    Wydawca:
    Instytut Medycyny Wsi
    Opis:
    Hymenolepis diminuta is a cosmopolitan parasite of rats and mice which is very rare in humans. This study presents the case of a 3-year-old boy infected with Hymenolepis diminuta in Poland. The diagnosis was based on eggs found and their morphology in the patient’s stool.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2014, 21, 3
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    First molecular characterization of Dobrava-Belgrade virus found in Apodemus flavicollis in Poland
    Autorzy:
    Kolodziej, M.
    Melgies, A.
    Joniec-Wiechetek, J.
    Michalski, A.
    Nowakowska, A.
    Pitucha, G.
    Niemcewicz, M.N.
    Powiązania:
    https://bibliotekanauki.pl/articles/2081717.pdf
    Data publikacji:
    2018
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    Polska
    phylogenetic analysis
    Apodemus flavicollis
    Dobrava-Belgrade virus
    orthohantaviruses
    Opis:
    Introduction. Dobrava-Belgrade virus (DOBV) is one of the emerging pathogens which have been reported during the last decades in Europe and have attracted the attention of researchers. The course of infection among humans may have a varied course – from the completely asymptomatic to the more severe forms, such as haemorrhagic fever with renal syndrome (HFRS). DOBV is hosted and carried by rodents like Apodemus flavicollis or A. agrarius, which occur commonly in Europe. Objective. To-date, orthohantaviruses have been reported in Poland, both in humans and animals, but detailed countryscale studies have not yet been carried out. The aim of the study was molecular characterization of a strain which was found in A. flavicollis in south-eastern Poland. Materials and method. The phylogenetic analysis of the first Dobrava-Belgrade virus found in A. flavicollis in the subcarpathian region of south-eastern Poland, presented in this study, was performed after virus proliferation in cell culture and sequencing of specific PCR products. Results. Based on genetic sequences of fragments of three segments (S, M and L), the isolated virus was assigned to the Dobrava genotype, taking into consideration the most current classification of the DOBV species. Conclusions. The Dobrava-Belgrade virus strain isolated from A. flavicollis in the subcarpathian region of south-eastern Poland, has been molecularly characterized and assigned to Dobrava genotype, thereby the occurrence of that genotype in Poland has been confirmed by molecular techniques.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2018, 25, 2; 368-373
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Severe Influenza Outbreak in Western Ukraine in 2009 – a molecular-epidemiological study
    Autorzy:
    Kocik, J.
    Niemcewicz, M.
    Johns, M.
    Jerke, K.
    Michalski, A.
    Bielecka, A.
    Lasocki, K.
    Gawel, J.
    Bielawska-Drozd, A.
    Joniec, J.
    Kolodziej, M.
    Graniak, G.
    Goniewicz, M.
    Kubiak, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/50555.pdf
    Data publikacji:
    2013
    Wydawca:
    Instytut Medycyny Wsi
    Opis:
    Introduction: In the autumn of 2009 the authors participated in a humanitarian operation in Western Ukraine by undertaking an epidemiological investigation of an influenza-like-illness (ILI) in the L’viv Oblast region. Mobile biological survey teams took samples from civilian patients with severe acute respiratory distress syndrome, rapid transportation of the samples, and their molecular analysis in Poland to provide accurate results. Objective: The aim of the study was the molecular and epidemiological analysis of the biological samples collected. Material and Methods: Real-time reverse transcriptase polymerase chain reaction (real-time RT-PCR), multiplex PCR techniques, traditional Sanger Sequencing and classical viral culture methods were used. Results: Among the 124 influenza-like illness cases, ~50% (58) were positive for influenza A virus in WHO-CDC molecular assay, including subtyping. The specimens were further analyzed to confirm results and determine the genetic sequence. Phylogenetically, the nucleotide similarity of both the Ukraine specimens and reference A/California/7/2009 (pH1N1) was 99.2–99.3%. Oseltamivir resistance was not registered. HA1 region characterization showed an overall protein identity of 98.5–99.4%. Conclusions: An unexpected high contribution of influenza A was confirmed among ILI patients, as well as a very limited number of other detected viruses, indicate that the 2009 epidemic in western Ukraine was strongly related to novel influenza A/H1N1. The importance of swift sharing of information and reference laboratories networking in surveillance, as well as serving governments and international agencies in pursuing adequate actions, should be stressed.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2013, 20, 3
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Acute respiratory distress syndrome (ARDS) in the course of influenza A/H1N1v infection – genetic aspects
    Autorzy:
    Niemcewicz, M.
    Pajak, B.
    Michalski, A.
    Kocik, J.
    Kolodziej, M.
    Joniec, J.
    Graniak, G.
    Gawel, J.
    Marciniak-Niemcewicz, A.
    Kucharczyk, K.
    Prystupa, A.
    Witczak, A.
    Lasocki, K.
    Naylor, K.
    Goniewicz, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/49651.pdf
    Data publikacji:
    2013
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2013, 20, 4
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prevalence of Borrelia burgdorferi in ticks removed from skin of people and circumstances of being bitten - research from the area of Poland, 2012–2014
    Autorzy:
    Gałęziowska, E.
    Rzymowska, J.
    Najda, N.
    Kołodziej, P.
    Domzal-Drzewicka, R.
    Rzaca, M.
    Muraczyńska, B.
    Charzyńska-Gula, M.
    Szadowska-Szlachetka, Z.
    Ślusarska, B.
    Guty, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/2081592.pdf
    Data publikacji:
    2018
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    ticks
    Borrelia burgdorferi
    tick- borne disease
    Lyme disease
    tick’s bite
    Opis:
    Introduction. During feeding, the tick sucks blood from the host along with the pathogens that are in the blood, simultaneously exchanging its own pathogens with the host. Humans can also be a host. It is important to understand the most typical circumstances in which people might become infected with Borrelia burgdorferi. This knowledge will help to prepare health education programmes aimed at the prevention of Lyme disease and other tick-borne diseases. Objective. The aim of the study was to determine the percentage of ticks infected with Borrelia burgdorferi sensu lato, depending on the circumstances of getting bitten. Materials and method. The research material consisted of ticks acquired from people who had been bitten, and questionnaires completed by these people. 510 ticks were acquired from 257 females and 253 males. Following delivery of a tick for testing, the stage of its development was determined and a molecular assay of Borrelia burgdorferi DNA performed. Results. A positive result of the nested-PCR test was obtained in 78 ticks, which represents 15.30% of all ticks. The infected ticks were collected from male (41 ticks – 52.56%) and female subjects (37 ticks – 47.44%). The biggest number of infected ticks were collected in autumn (54 ticks – 69.23%) and from people who had been into forests (44 ticks – 56.41%). Among the people from whom the infected ticks were acquired, the dominating group included persons over 16 years of age (53 persons – 67.95%) and children aged 0–5 years (16 persons – 20.51%). One in four infected ticks were acquired from the southwestern (20 ticks – 25.64%) and eastern regions of Poland (21 ticks – 26.92%). Conclusion. Infestation of ticks infected with Lyme disease spirochete in this study proved to be variable and depend on the season, the area of tick attack and the region in Poland. The results of the study clearly show that ticks infected with Borrelia burgdorferi inhabit all regions of Poland. The results are consistent with National Institute of Hygiene data which indicates that Lyme disease cases are recorded in all regions of Poland.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2018, 25, 1; 31-35
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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