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    Tytuł:
    Wstępne wyniki badań seroepidemiologicznych i klinicznych w kierunku gorączki Q u osób zawodowo narażonych
    Preliminary results of seroepidemiological and clinical examinations for Q fever among an occupationally-exposed population – preliminary report
    Autorzy:
    Galinska, E.M.
    Knap, J.P.
    Chmielewska-Badora, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/941351.pdf
    Data publikacji:
    2011
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    gorączka q
    coxiella burnetii
    epidemiologia
    diagnostyka
    narażenie zawodowe
    Opis:
    Gorączka Q (febris Q, coxiellosis) jest występującą globalnie chorobą ludzi i wielu gatunków zwierząt. Wywołuje ją, namnażająca się wewnątrzkomórkowo, bakteria Coxiella burnetii (rząd Legionellales), wytwarzająca spory – wyjątkowo wytrzymałe na działanie czynników fi zyko-chemicznych. W Polsce, jako choroba ludzi, znana jest od 1956 roku, zaś najczęstszym źródłem zakażenia dla ludzi są: zakażone bydło i owce oraz skażone środowisko bytowania tych zwierząt. Wycinkowo jedynie rozpoznana epidemiologicznie i sporadycznie diagnozowana u ludzi, występuje niewątpliwie na terenie całego kraju. Ofi cjalnie zgłaszane przypadki u ludzi, odzwierciedlają (według szacunku jednego z nas, jedynie około 1% przypadków klinicznych u ludzi w Polsce). Motywem przedstawionych poniżej badań, były 3 ogniska epizootyczno-epidemiczne, które pojawiły się latem i wczesną jesienią 2008 roku, na pograniczu województw lubelskiego i podkarpackiego, zrazu u krów mlecznych i wtórnie, u ludzi z grup narażenia zawodowego. W pracy przedstawiono wstępne wyniki badań w kierunku gorączki Q u osób zawodowo narażonych. Przebadano serologicznie grupę 135 osób. W celu wykazania obecności przeciwciał IgG zastosowano metodę immunofl uorescencji pośredniej (IFA) w fazie I i II oraz metodę odczynu wiązania dopełniacza (OWD) w fazie II. Przedstawione wyniki traktujemy jako wstępne, zaś badania kontynuujemy wespół z Laboratorium Diagnostyki Serologicznej Państwowego Instytutu Weterynaryjnego – Państwowego Instytutu Badawczego w Puławach, której kierownikiem jest dr wet. Krzysztof Niemczuk, uczestnik wspólnego Grantu, oraz z oddziałami obserwacyjno-zakaźnymi w Biłgoraju i Dębicy i Narodowym Instytutem Zdrowia Publicznego-Państwowym Zakładem Higieny
    Źródło:
    Medycyna Ogólna i Nauki o Zdrowiu; 2011, 17(46), 1; 2-6
    2083-4543
    Pojawia się w:
    Medycyna Ogólna i Nauki o Zdrowiu
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of main T-cell subsets and activated T supressor/cytotoxic cells in patients with Borrelia burgdorferi s. lato only infection and co-infections with Anaplasma phagocytophilum, Bartonella spp. and Babesia microti
    Autorzy:
    Tomasiewicz, K.
    Chmielewska-Badora, J.
    Zwolinski, J.
    Murias-Brylowska, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/50180.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2016, 23, 1
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wpływ dioksyn na środowisko i organizm człowieka
    Effect of dioxins on the environment and human body
    Autorzy:
    Zukiewicz-Sobczak, W.
    Chmielewska-Badora, J.
    Krasowska, E.
    Wojtyla, A.
    Piatek, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/3981.pdf
    Data publikacji:
    2012
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Medycyna Ogólna i Nauki o Zdrowiu; 2012, 18(47), 1
    2083-4543
    Pojawia się w:
    Medycyna Ogólna i Nauki o Zdrowiu
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Serological survey in persons occupationally exposed to tick-borne pathogens in cases of co-infections with Borrelia burgdorferi, Anaplasma phagocytophilum, Bartonella spp. and Babesia microti
    Autorzy:
    Chmielewska-Badora, J.
    Moniuszko, A.
    Zukiewicz-Sobczak, W.
    Zwolinski, J.
    Piatek, J.
    Pancewicz, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/49834.pdf
    Data publikacji:
    2012
    Wydawca:
    Instytut Medycyny Wsi
    Opis:
    Sera of 39 farmers, 119 foresters and 32 blood donors were investigated for the presence of antibodies against B. burgdorferi, A. phagocytophilum, B. microti and Bartonella spp. Semi-quantitative indirect immunofluorescence test was used to measure titers of anti-A. phagocytophilum, B. microti and Bartonella spp. IgG. ELISA test was used to measure titers of anti-B. burgdorferi IgM and IgG. B. burgdorferi was the most frequently observed among all the examined pathogens. 27.7% of farmers, 23.1% of forestry workers and 37.5% of control group were infected with Bartonella spp. Anti-A. phagocytophilum and anti-B. microti reactions were observed rarely. Sera of persons with single infection dominated in farmers and forestry workers. Co-infection with 2 pathogens was observed more frequently in forestry workers and farmers than in the control group. Co-infections with 3-4 pathogens were observed only in forestry workers. Among the observed co-infections, the most frequent were: B. burgdorferi with Bartonella spp. and B. burgdorferi with A. phagocytophilum. Moreover, in forestry workers, triple coinfections with B. burgdorferi, Bartonella spp. and A. phagocytophilum and one quadruple coinfection were observed. Persons with occupational risk of tick bites, especially forestry workers, more often have anti-B. burgdorferi antibodies and are more often co-infected with various tick-borne pathogens than the persons from the control group. It seems that more often coinfections in persons with occupational risk of tick bites are a consequence of the higher incidence of infection with B. burgdorferi, as anti-B. microti, A. phagocytophilum and Bartonella spp. antibodies are not more commonly prevalent in persons with occupational risk of tick bites than in healthy volunteers.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2012, 19, 2
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prevalence of Anaplasma phagocytophilum in Ixodes ricinus ticks determined by polymerase chain reaction with two pairs of primers detecting 16S rRNA and ankA genes
    Autorzy:
    Chmielewska-Badora, J
    Zwolinski, J.
    Cisak, E.
    Wojcik-Fatla, A.
    Buczek, A.
    Dutkiewicz, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/51023.pdf
    Data publikacji:
    2007
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    Lublin region
    Polska
    pathogen
    Ixodes ricinus
    Eastern Poland
    tick
    determination
    animal pathogen
    human pathogen
    ankA gene
    16S rRNA gene
    granulocytic anaplasmosis
    bacteria
    Anaplasma phagocytophilum
    polymerase chain reaction
    Opis:
    A total of 684 Ixodes ricinus ticks (321 nymphs, 184 males, and 179 females) were collected by fl agging lower vegetation in 6 forest districts located on the territory of Lublin province (eastern Poland). Ticks were examined by polymerase chain reaction (PCR) method for the presence of Anaplasma phagocytophilum DNA with two pairs of primers: EHR521/EHR747 for detecting 16S rRNA gene, and LA6/LA1 for detecting ankA gene. To study the relationship between infection in ticks and people occupationally exposed to tick bite, blood serum samples of 261 forestry workers employed in the same forest districts were examined by immunofl uorescence method for the presence of specifi c antibodies against A. phagocytophilum. A total of 70 ticks out of 684 examined (10.2%) showed the presence of A. phagocytophilum 16S rRNA gene. The prevalence of infection was signifi cantly dependent on tick’s stage (χ2=49.2, p<0.00001) and geographical locality (χ2=34.4, p<0.00001). The percentage of I. ricinus females infected with A. phagocytophilum (24.6%) was signifi cantly greater compared to males (6.5%) and nymphs (4.4%) (p<0.00001). Only 19 ticks out of 684 examined (2.8%) showed the presence of A. phagocytophilum ankA gene, signifi cantly less compared to 16S rRNA gene (p<0.00001). The prevalence of infection demonstrated by the presence of ankA gene was also signifi cantly dependent on tick’s stage (χ2=23.6, p<0.00001) but not on locality (χ2=9.8, p=0.082). A signifi cant correlation was found between the presence of A. phagocytophilum 16S rRNA gene in I. ricinus female ticks from the particular forest districts and the serologic response to A. phagocytophilum of forestry workers employed in the same districts (p<0.05). No signifi cant correlation was found between the presence of A. phagocytophilum ankA gene in I. ricinus ticks and serologic response of exposed workers. In conclusion, detection of A. phagocytophilum infection in ticks by PCR with the use of EHR521/EHR747 primers detecting 16S rRNA gene is signifi cantly more sensitive compared to LA6/LA1 primers detecting ankA gene.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2007, 14, 2
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    „Dopalacze” - eksperyment wysokiego ryzyka, w ujęciu przepisów nowej ustawy
    ‘Legal highs’ - an experiment at high risk, in terms of provisions of the new act
    Autorzy:
    Zukiewicz-Sobczak, W.
    Chmielewska-Badora, J.
    Krasowska, E.
    Wojtyla, A.
    Piatek, J.
    Zwolinski, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/4011.pdf
    Data publikacji:
    2012
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Medycyna Ogólna i Nauki o Zdrowiu; 2012, 18(47), 2
    2083-4543
    Pojawia się w:
    Medycyna Ogólna i Nauki o Zdrowiu
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Allergenic potential of moulds isolated from buildings
    Autorzy:
    Zukiewicz-Sobczak, W.
    Sobczak, P.
    Krasowska, E.
    Zwolinski, J.
    Chmielewska-Badora, J.
    Galinska, E.M.
    Powiązania:
    https://bibliotekanauki.pl/articles/51660.pdf
    Data publikacji:
    2013
    Wydawca:
    Instytut Medycyny Wsi
    Opis:
    Introduction: Moulds are the one of the known biological factors that have a negative impact on human health. Moulds are commonly present in residential and work environments. Materials plentiful in organic compounds, such as building materials or paints, are a splendid substrate for the development of moulds. The first documented mention of a study describing the harmful effects caused by moulds in buildings emerged in the early nineteenth century. In Copenhagen and then in Padua, moulds of the genus Penicillium, Cladosporium and Mucor were found in buildings. Objective: To present the current state of the allergic properties and other negative health effects caused by moulds isolated from buildings. Brief description of the state of knowledge: The literature and own research clearly shows that moulds and their secondary metabolites can evoke toxic effects on human and animal health, and cause symptoms similar to allergic diseases. These allergens have been noted in spores as well as other fungal fragments; however, most allergens are located in germinating spores, in the hyphal tips and in mycelia. Fungal allergy can express in different ways: asthma, rhinitis, conjunctivitis, urticaria and atopic dermatitis. Fungal allergy antigen is bound to IgE-dependent reactions but also to reactions independent of IgE. Conclusions: Moulds are a significant but difficult to detect etiologic agent of different allergic diseases. Prevention of this diseases is important for patients with suspected connection between common allergic symptoms and affinity with moulds.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2013, 20, 3
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Study on Lyme borreliosis focus in the Lublin region [eastern Poland]
    Autorzy:
    Cisak, E
    Chmielewska-Badora, J.
    Zwolinski, J.
    Wojcik-Fatla, A.
    Zajac, V.
    Skorska, C.
    Dutkiewicz, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/51535.pdf
    Data publikacji:
    2008
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    borreliosis
    Polska
    rural inhabitant
    Lyme borreliosis
    tick
    seroepidemiology
    Ixodes ricinus
    Borrelia burgdorferi
    clinical case
    Lublin region
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2008, 15, 2
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Obesity and poverty paradox in developed countries
    Autorzy:
    Zukiewicz-Sobczak, W.
    Wroblewska, P.
    Zwolinski, J.
    Chmielewska-Badora, J.
    Adamczuk, P.
    Krasowska, E.
    Zagorski, J.
    Oniszczuk, A.
    Piatek, J.
    Silny, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/49814.pdf
    Data publikacji:
    2014
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2014, 21, 3
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of psychoactive and intoxicating substances in legal highs
    Autorzy:
    Zukiewicz-Sobczak, W.
    Zwolinski, J.
    Chmielewska-Badora, J.
    Krasowska, E.
    Piatek, J.
    Sobczak, P.
    Wojtyla, A.
    Fornal, E.
    Kuczumow, A.
    Bilinski, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/51459.pdf
    Data publikacji:
    2012
    Wydawca:
    Instytut Medycyny Wsi
    Opis:
    “Legal highs” known also as “smarts”, “legal drugs” or “boosters” contain in their composition psychoactive substances the production, sale and possession of which are not prohibited in legislation. They are offered for sale under the cover of collectors’ items, a salt bath, aroma sticks, or plant fertilizer. Marketing was the reason for such high sales of these “highs” in Poland. The phenomenon became of concern when information became available about the first cases of tragic health consequences. Raising the awareness of youth about the level of imminent danger and serious consequences associated with the use of legal highs may be a very effective way to develop appropriate attitudes of young people, and in the light of their own health can help them take proper life decisions. “Legal highs” are substances of natural or synthetic origin having psychostimulating properties. These compounds may differ in chemical structure, potency, half-life, metabolism and severity of side effects. Their pharmacological activity is associated with changes in the neurotransmitter system. After higher doses of “legal highs” psychotic symptoms may occur: visual and auditory hallucinations resembling schizophrenic endogenous psychoses. An alarming fact is the underestimation of the adverse effect of these substances on human health. Any actions aimed at improving this situation are extremely important; therefore, in one of the key projects undertaken at the Institute of Rural Health in Lublin, in cooperation with other scientific institutes, concerned the analysis of a selected series of “legal highs”. This research was meant top serve as a source of information for science and medicine, and for popularizing knowledge about legal highs.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2012, 19, 2
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prevalence of antibodies against selected zoonotic agents in forestry workers from eastern and southern Poland
    Autorzy:
    Zukiewicz-Sobczak, W.
    Zwolinski, J.
    Chmielewska-Badora, J.
    Galinska, E.M.
    Cholewa, G.
    Krasowska, E.
    Zagorski, J.
    Wojtyla, A.
    Tomasiewicz, K.
    Klapec, T.
    Powiązania:
    https://bibliotekanauki.pl/articles/49884.pdf
    Data publikacji:
    2014
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2014, 21, 4
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Efficacy of crizotinib therapy for a patient with non-small cell lung cancer with ALK gene rearrangement – case report and review of current therapeutic options
    Autorzy:
    Bargiel, J.B.
    Cabaj, J.
    Chmielewska, I.
    Milanowski, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2098542.pdf
    Data publikacji:
    2021
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    non-small cell lung cancer
    crizotinib
    therapy
    gene rearrangement
    tyrosine kinase inhibitor
    patient
    Opis:
    Introduction. Currently, nearly 23,000 cases of lung cancer are diagnosed in Poland annually, of which 5% are cases with rearrangements in the ALK gene. In recent years, tremendous progress has been made in understanding the genetic makeup of this type of cancer, which has enabled the use of new therapies, in particular, molecularly targeted drugs. Crizotinib is the first oral small molecule inhibitor of ALK, MET and ROS1 receptor tyrosine Kinases approved by the European Medicines Agency(EMA). Case report. The paper presents the case of a 62-year-old patient diagnosed with non-small cell lung cancer with rearrangement in the ALK gene in stage IV of the disease. The patient was qualified for treatment with crizotinib under the B6 drug programme. Treatment started in May 2019. During treatment, assessment was made at 3 control points, where the first and second showed a partial response according to the RECIST 1.1 scale; in the next assessment, the response was maintained in the form of disease stabilization.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2021, 15, 3; 151-154
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Not only cigarettes - other culprits of lung cancer
    Autorzy:
    Grzywa-Celińska, A.
    Drogoń, I.
    Emeryk-Maksymiuk, J.
    Chmielewska, I.
    Milanowski, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085178.pdf
    Data publikacji:
    2019
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    lung cancer
    cigarettes
    e-cigarettes
    Opis:
    Introduction. Before cigarettes became popular, lung cancer was an extremely rare disease, but currently it is the most common cause worldwide of cancer death in both genders. Therefore, it constitutes a huge epidemiological, diagnostic and socio-economic challenge around the world. In Poland, lung cancer is the second most common carcinoma in both men and women, and it is also the most prevailing cause of carcinous death. Undoubtedly, although smoking classical cigarettes is the strongest risk factor of developing the cancer, unfortunately it is not the only one. Objective. The aim of this study was to present smoking-related factors, e.g. cigars, pipes, e-cigarettes or marijuana smoking, etiologically related to lung cancer incidence.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2019, 26, 4; 661-664
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effects of interior design on wellness – eye tracking analysis in determining emotional experience of architectural space. A survey on a group of volunteers from the Lublin region, Eastern Poland
    Autorzy:
    Tuszyńska-Bogucka, W.
    Kwiatkowski, B.
    Chmielewska, M.
    Dzieńkowski, M.
    Kocki, W.
    Pełka, J.
    Przesmycka, N.
    Bogucki, J.
    Galkowski, D.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085475.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    supportive design
    healing environment
    emotional significance of space
    optimisation of treatment conditions
    eye tracking in medical research
    Opis:
    Introduction and objective. Using the concepts of Ulrich’s theory of supportive design and Malkin’s healing environment, an eye tracking experiment was designed in order to measure respondents’ reactions while looking at visualisations of various interiors, with the aim of verifying whether certain parameters of an interior are related to emotional reactions in terms of positive stimulation, and the sense of security and comfort. Materials and method. 12 boards were designed, incorporating standard features of an interior, i.e. (1) proportions, (2) lighting, (3) colour scheme of a room, as well as (4) the colours and spatial arrangement of furnishings. Respondents’ reactions were recorded with an eye tracker Tobii TX300 and supplemented by self-descriptions of emotional reactions. Results. The results showed that the varying spatial and colour arrangements presented in the interior visualisations provoked different emotional responses, confirmed by pupil reaction parameters, as measured by the eye tracking device. Conclusions. Architectural space can have a diverse emotional significance and impact on an individual’s emotional state. This is an important conclusion from the point of view of optimising and creating the so-called supportive and healing environment. The results have implications for the interpretation of the pupil diameter as an index of emotional reactions to different architectural space visualisations. Testing the eye tracker as a method helpful in diagnosing the emotional reactions to features of the interior is justified, and can provide an effective tool for early diagnosis of the impact of architectural space on the well-being of individuals. It can also be a good form of testing the emotional significance of architectural designs before they are implemented.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2020, 27, 1; 113-122
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-14 z 14

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