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Tytuł:: Differences in the expression of selected genes associated with cell stress response in a PTSD patient and in healthy individuals – a case study
Autorzy:: Rasmus, Anna
Półrola, Paweł
Góral-Półrola, Jolanta
Żychowska, Małgorzata
Mirski, Andrzej
Knapik, Henryk
Powiązania:: https://bibliotekanauki.pl/articles/986669.pdf
Data publikacji:: 2017
Wydawca:: Instytut Medycyny Wsi
Tematy:: cell stress
ptsd patient
expression of selected genes
healthy individuals
Opis:: Objective. The aim of the study was determination of the level in expression genes associated with cell stress response in a patient with PTSD. Case study. A 57-year-old PTSD patient, A.P., was the subject of the study. Blood samples were taken from the ulnar vein to assess the relative expression of the tested genes in leukocytes via a quantitative reverse transcription polymerase chain reaction (qRT-PCR). Results. A considerably decreased level in the expression HSF-1, NF-kB, Hif-1 and IL6 m-RNA was observed in the patient when compared to the control group. A low expression in HSPA1A, HSPB1, IL10 and CRP m-RNA compared with the control group was also noted. Conclusion. It is possible that the lower level of transcriptional factors: HSF-1, NF-kB and Hif-1 as well as IL6 m-RNA may be associated with the effect of the PTSD patient’s treatment.
Źródło:: Annals of Agricultural and Environmental Medicine; 2017, 24, 2
1232-1966
Pojawia się w:: Annals of Agricultural and Environmental Medicine
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Early response of selected haemostatic and haematological parameters to physical activity in young women - the potential impact of oral contraceptives
Autorzy:: Jastrzębska, Maria
Żyżniewska-Banaszak, Ewelina
Nawrot, Małgorzata
Marcinowska, Zuzanna
Siennicka, Aldona
Chełstowski, Kornel
Stachowiak, Paweł
Kordaczuk, Michał
Przybycień, Krzysztof
Clark, Jeremy
Powiązania:: https://bibliotekanauki.pl/articles/972632.pdf
Data publikacji:: 2017
Wydawca:: Instytut Medycyny Wsi
Tematy:: exercise
contraception
haemostasis
platelet function tests
cell derived microparticles
Opis:: Introduction and objective. Exercise (submaximal) in untrained subjects can modify haemostasis toward hypercoagulability, especially among women using oral contraceptives (OC). The aim of this study was to investigate whether this can be explained by platelet haemostasis and changes in the generation of membrane microparticles. Materials and method. Young, healthy women (n=60) were divided into 2 equal groups: a study group OC (+) who had used OC for >3 months, and controls who had never used oral contraceptives OC(-). Exclusion criteria: those with systematic daily physical activity. Participants were subjected to treadmill exercise (Cardiac Diagnostic System; model CH2000) using the Bruce protocol/ AHA guidelines. Platelet aggregation with arachidonic acid (ASPI test) or ADP (ADP test), membrane microparticle (MP) activity, plasma coagulation times (APTT/PT) and blood count were determined before and 45 minutes after exercise. Results. Before exercise, the OC(+) group had slightly higher platelet aggregation (ADP test), significantly lower MP activity, slightly lower PLT and slightly higher PDW rate. Exercise caused slight inhibition of platelet aggregation (ASPI test), and significant decrease in MP activity – only in the OC(-) group. After exercise, in both groups there was a significant decrease in PLT and increase in WBC, more pronounced in OC(+) group. Conclusions. Submaximal exercise was beneficial for haemostasis in women not using hormonal contraception, associated primarily with reduced MP activity. No beneficial effects of physical activity were found for women using hormonal contraceptives, possibly associated with a hypercoagulable state, and higher reactivity of blood platelets under the influence of the use of contraceptives.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2017, 11, 1
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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