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Wyszukujesz frazę "Paul, D." wg kryterium: Autor


Wyświetlanie 1-2 z 2
Tytuł:
Toxic alveolitis after inhalation of a water repellent
Autorzy:
Epping, Guido
Van Baarlen, Joop
Van Der Valk, Paul D.
Powiązania:
https://bibliotekanauki.pl/articles/2185379.pdf
Data publikacji:
2011-12-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
water repellent
toxic alveolitis
acute interstitial pneumonitis
broncho-alveolar lavage
Oil-Red-O-stain
Opis:
Inhalation of fluorocarbon polymers can cause pulmonary toxicity. Although multiple cases of lung injury have been reported, cellular characterization of the associated alveolitis occurring acutely after inhalation is limited. We report the case of a previously healthy woman who presented at our Emergency Department with an acute pneumonitis following inhalation of a fluorocarbon polymer-based rain-proofing spray. Bronchoalveolar lavage (BAL) performed shortly after the presentation showed an elevated total cell count, with a high proportion of neutrophils (58%) and eosinophils (9%). In addition, a lipid stain (Oil-Red-O-stain) showed a high level of lipid laden macrophages, a marker that could reflect a direct toxic effect of the spray on alveolar cells. The patient made a full recovery after four days of in-hospital observation with supportive care.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2011, 24, 4; 409-413
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Serum fluoride levels in ambulance staff after commencement of methoxyflurane administration compared to meta-analysis results for the general public
Autorzy:
Allison, Serah J.
Docherty, Paul D.
Pons, Dirk
Chase, James G.
Powiązania:
https://bibliotekanauki.pl/articles/2093863.pdf
Data publikacji:
2021-12-13
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
meta-analysis
prospective studies
fluorides
ambulances
fluoride poisoning
methoxyflurane
Opis:
ObjectivesAmbulance officers administering methoxyflurane as an inhalational analgesic may be exposed to trace vapor. Fluoride is a methoxyflurane metabolite, and has been associated with acute renal failure in anesthesia patients and skeletal fluorosis with chronic elevated serum levels from other sources. However, there has been no direct measurement of serum fluoride in occupationally exposed ambulance officers. Thus, this study directly measures serum fluoride over a prolonged period in order to determine renal toxic and skeletal fluorosis risk to ambulance officers who are administering methoxyflurane.Material and MethodsSerum inorganic fluoride concentrations were measured in a prospective observational study of 12 emergency medical technicians (EMTs). The study took 7 serum fluoride measurements over 24 months. A meta-analysis of healthy adult serum fluoride ranges was also conducted.ResultsThe typical healthy adult serum fluoride range was determined to be 0.21–2.11 μmol/l (p < 0.001). The EMTs’ baseline median (IQR) serum fluoride concentrations were 0.4 μmol/l (0.2; 1.0) with maximum 1.6 μmol/l. The EMTs’ overall median serum fluoride was 0.4 μmol/l (0.2; 1.3) with maximum 4.0 μmol/l, usually within healthy reference ranges. All results were ≤10% of the suggested single-dose renal toxic threshold. One result was above a threshold for skeletal fluorosis. The highest measured serum fluoride was 24% of the lowest level associated with radiologic evidence of fluorosis. There was no evidence overall of increasing serum fluoride levels.ConclusionsThere was no evidence that EMTs’ exposure to methoxyflurane resulted in sustained increased serum fluoride. These results imply EMTs’ occupational safety from acute renal toxicity when activated carbon filtration is used on patient exhalation. However, 1 serum fluoride result above a skeletal fluorosis threshold suggests that the risk of mild skeletal fluorosis cannot be excluded.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2021, 34, 6; 767-777
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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