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    Wyświetlanie 1-7 z 7
    Tytuł:
    Compact cyclotrons for the production of tracers and radiopharmaceuticals
    Autorzy:
    Paans, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/146155.pdf
    Data publikacji:
    2003
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    positron emission tomography (PET)
    cyclotron
    radionuclide production
    Opis:
    Positron Emission Tomography (PET) is a method for determining biochemical and physiological processes in vivo in a quantitative manner. The most commonly used radionuclides are 11C, 13N, 15O and 18F, with respective half-lives of approximately 20 min, 10 min, 2 min, and 110 min. 18F labeled FDG (fluoro-2-deoxy-D-glucose) is now the most frequently used radiopharmaceutical and finds its application prominently in the field of oncology. Originally, the production of these radionuclides was performed with the existing accelerators, designed for nuclear physics, but with increasing interest in the PET methodology specially designed PET-production cyclotrons became available. The nuclear reactions involved are (p,n), (d,n), (p,a) and (d,a) and the thresholds for the nuclear reactions involved are 5 to 6 MeV. Based on these values and on other parameters, a proton 15 to 20 MeV cyclotron is often chosen. Since the half-life of a radionuclide limits the production time, the maximum beam current is an important parameter, together with the target construction, for the ultimate yield obtainable. In the development of special PET production cyclotrons, attention has also been paid to improve the extraction efficiency and the possibility of multiple extractions by designing negative ion cyclotrons. Commercial cyclotrons can often be acquired as an easy to operate integrated radionuclide production unit including targetry and some units. Regional FDG factories are nowadays being created to fulfil the demand for PET radiopharmaceutics. The possible choices in commercially available cyclotrons for the production of PET radionuclides will be discussed.
    Źródło:
    Nukleonika; 2003, 48,suppl.2; 169-172
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Preparation, quality control and biodistribution studies of [61Cu]-oxinate for PET tumor imaging
    Autorzy:
    Jalilian, A. R.
    Zolghadri, S.
    Faghihi, R.
    Yousefnia, H.
    Garousi, J.
    Shafaii, K.
    Bolourinovin, F.
    Powiązania:
    https://bibliotekanauki.pl/articles/148094.pdf
    Data publikacji:
    2009
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    copper-61
    8-hydroxyquinoline
    positron emission tomography
    fibrosarcoma
    Opis:
    Targeting apoptosis is an interesting issue in molecular imaging and various modalities have been presented. However, recent experiences in nuclear pharmacy demonstrated the application of small tracer molecules is more desired. This work was conducted for production of a radiolabeled copper complex, i.e. 61Cu-oxinate as a potential PET tracer for apoptosis imaging in oncology. Cu-61 was prepared by natural zinc target irradiation with 22 MeV protons (150 miA) via the natZn(p, xn)61Cu nuclear reaction with a yield of 3.33 mCi/miAh. In order to obtain the best labeling method, optimization reactions were performed for pH, temperature and concentration followed by solid phase extraction. Biodistribution of the tracer was studied in wild-type and fibrosarcoma bearing mice. Under the optimized conditions, radio-thin-layer chromatography (RTLC) and HPLC showed radiochemical purities of 99.99% and 97% respectively (with a minimum specific activity of 16 Ci/mM). Biodistribution of the tracer in fibrosarcoma bearing mice demonstrated a significant tumor uptake after 3 h. Tumor:blood and tumor:muscle ratios were 2.0 and 6.0 after 3 h, respectively.
    Źródło:
    Nukleonika; 2009, 54, 3; 175-179
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Application of the compress sensing theory for improvement of the TOF resolution in a novel J-PET instrument
    Autorzy:
    Raczyński, L.
    Moskal, P.
    Kowalski, P.
    Wiślicki, W.
    Bednarski, T.
    Białas, P.
    Czerwiński, E.
    Gajos, A.
    Kapłon, Ł.
    Kochanowski, A.
    Korcyl, G.
    Kowal, J.
    Kozik, T.
    Krzemień, W.
    Kubicz, E.
    Niedźwiecki, S.
    Pałka, M.
    Rudy, Z.
    Salabura, P.
    Gupta-Sharma, N.
    Silarski, M.
    Słomski, A.
    Smyrski, J.
    Strzelecki, A.
    Wieczorek, A.
    Zieliński, M.
    Zoń, N.
    Powiązania:
    https://bibliotekanauki.pl/articles/146280.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    compressed sensing
    positron emission tomography
    time-of-flight
    Opis:
    Nowadays, in positron emission tomography (PET) systems, a time of fl ight (TOF) information is used to improve the image reconstruction process. In TOF-PET, fast detectors are able to measure the difference in the arrival time of the two gamma rays, with the precision enabling to shorten signifi cantly a range along the line-of-response (LOR) where the annihilation occurred. In the new concept, called J-PET scanner, gamma rays are detected in plastic scintillators. In a single strip of J-PET system, time values are obtained by probing signals in the amplitude domain. Owing to compressive sensing (CS) theory, information about the shape and amplitude of the signals is recovered. In this paper, we demonstrate that based on the acquired signals parameters, a better signal normalization may be provided in order to improve the TOF resolution. The procedure was tested using large sample of data registered by a dedicated detection setup enabling sampling of signals with 50-ps intervals. Experimental setup provided irradiation of a chosen position in the plastic scintillator strip with annihilation gamma quanta.
    Źródło:
    Nukleonika; 2016, 61, 1; 35-39
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Preparation and biological evaluation of [61Cu]bleomycin complex as a possible PET radiopharmaceutical in normal and fibrosarcoma-bearing animals
    Autorzy:
    Jalilian, A. R.
    Zandi, H.
    Sardari, D.
    Akhlaghi, M.
    Kamali-Dehghan, M.
    Shafaei, K.
    Majdabadi, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/148090.pdf
    Data publikacji:
    2009
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    radiopharmaceutical
    copper-61
    bleomycin
    positron emission tomography
    fibrosarcoma
    Opis:
    [61Cu]bleomycin ([61Cu]BLM) was prepared using [61Cu]CuCl2 produced via natZn(p,x)61Cu. [61Cu]BLM was prepared under optimized conditions (room temperature, 45 min, 0.1 mg bleomycin for 92.5–370 MBq 61CuCl2) with radiochemical purity over 98% shown by HPLC and RTLC. [61Cu]BLM was administered into normal and tumor bearing rodents up to 210 min followed by biodistribution and co-incidence imaging studies. A significant tumor/non tumor accumulation was observed either by animal sacrification or an imaging method. [61Cu]BLM can be a potential PET radiotracer for tumor imaging.
    Źródło:
    Nukleonika; 2009, 54, 2; 135-141
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Development of [66Ga]oxine complex; a possible PET tracer
    Autorzy:
    Jalilian, A.
    Rowshanfarzad, P.
    Sabet, M.
    Rahiminejad-Kisomi, A.
    Rajamand, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/146276.pdf
    Data publikacji:
    2006
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    gallium-66
    oxine
    positron emission tomography
    blood cell labeling
    stability
    Opis:
    The aim of this work is development of a possible blood cell labeling agent for ultimate use in PET. Gallium-66 (T1/2 = 9.49 h) is an interesting radionuclide that has a potential for positron emission tomography (PET) imaging of biological processes with intermediate to slow target tissue uptake. Oxine has been labeled with this radionuclide in the form of [66Ga]gallium chloride for its possible diagnostic properties. In this study, 66Ga was produced at a 30 MeV cyclotron (IBA-Cyclone 30) via the 66Zn(p,n)66Ga reaction. The production yield was 445.5 MBq/mAh. The [66Ga]oxine complex was obtained at pH = 5 in phosphate buffer medium at 37°C in 10 min. Radio-TLC showed a radiochemical purity of more than 98 š 2%. The chemical stability of the complex was checked in vitro with a specific activity of 1113 GBq/mmol. The serum stability and log P of the complex were calculated. The produced [66Ga]oxine can be used for diagnostic studies, due to its desirable physico-chemical properties both in vitro and in vivo according to internationally accepted limits.
    Źródło:
    Nukleonika; 2006, 51, 3; 155-159
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Preliminary design and simulation of a spherical brain PET system (SBPET) with liquid xenon as scintillator
    Autorzy:
    Moghaddam, N. M.
    Karimian, A.
    Mostajaboddavati, S. M.
    Vondervoort, E.
    Sossi, V.
    Powiązania:
    https://bibliotekanauki.pl/articles/146444.pdf
    Data publikacji:
    2009
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    positron emission tomography (PET)
    Monte Carlo simulation
    GATE
    liquid xenon
    brain imaging
    Opis:
    Preliminary design of a spherical brain PET (SBPET) using liquid xenon (LXe) as detector is considered in this research work. The major advantage of a spherical design is the large solid angle of acceptance which improves the sensitivity and increases signal-to-noise ratio (SNR) of the image. The use of a liquid active medium enabled us to design a spherical detector. LXe, due to the intrinsic physical properties, is an excellent liquid medium for accurate tracking of gamma rays in the relevant energy range. The performance of SBPET was evaluated by Monte Carlo simulation tools (GATE) and compared to ECAT HRRT. The numerical results showed the SBPET has a sensitivity of 1.14% and spatial resolution of ~2.7 mm FWHM which is superior to ECAT HRRT especially at high-count rates.
    Źródło:
    Nukleonika; 2009, 54, 1; 33-38
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    PF-6 an effective plasma focus as a source of ionizing radiation and plasma streams for application in material technology, biology and medicine
    Autorzy:
    Gribkov, V.
    Dubrovsky, A.
    Scholz, M.
    Jednorog, S.
    Karpiński, L.
    Tomaszewski, K.
    Paduch, M.
    Miklaszewski, R.
    Pimenov, V.
    Ivanov, L. I.
    Dyomina, E. V.
    Maslyaev, S. A.
    Orlova, M. A.
    Powiązania:
    https://bibliotekanauki.pl/articles/147424.pdf
    Data publikacji:
    2006
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    dense plasma focus (DPF)
    ion beam
    plasma beam
    X-ray beams
    surface damage
    microlithography
    radioenzymology
    positron emission tomography (PET)
    Opis:
    A review of results on the design and operation of the new efficient Dense Plasma Focus device PF-6 of medium size (transportable) having bank energy of ca. 7 kJ and possessing a long lifetime is presented. New data on the interaction of the pulsed fast ion beams and dense plasma streams generated at this apparatus with various materials are given. These results are compared with the analogous information received at the biggest facility PF-1000. It is shown that it is possible to have about the same power flux density (in the range of 105 109 W/cm2) in both devices however in different areas. Doses of soft X-rays produced by the device within the resists for the goals of microlithography and micromachining appear to be several times less that it is with the conventional X-ray tube. In biological application of this device, medium- and hard-energy X-rays are exploited in the field of radioenzymology. It was found that the necessary dose producing activation/inactivation of enzymes can be by several orders of magnitude lower if used at a high-power flux density in comparison with those received with isotope sources. In medicine, short-life isotope production for the goals of the positron emission tomography (medicine diagnostics) is possible by means of the fast ions generated within DPF. All these experiments are discussed in the framework of pulsed radiation physics and chemistry in its perfect sense thereto the criteria are formulated.
    Źródło:
    Nukleonika; 2006, 51, 1; 55-62
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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