- Tytuł:
- Enzymatic oxidation of substituted tryptamines catalysed by monoamine oxidase
- Autorzy:
-
Dragulska, S.
Kańska, M. - Powiązania:
- https://bibliotekanauki.pl/articles/146939.pdf
- Data publikacji:
- 2014
- Wydawca:
- Instytut Chemii i Techniki Jądrowej
- Tematy:
-
monoamine oxidase (MAO)
tryptamine
serotonin
isotope effects - Opis:
- The enzymatic deamination of 5-fl uorotryptamine and 5-hydroxytryptamine, 5-HT, catalysed by enzyme monoamine oxidase A (MAO-A, EC 1.4.3.4) was investigated using the kinetic (KIE) and solvent (SIE) isotope effects methods. The numerical values of deuterium isotope effects in the (1R) positions of 5-F-tryptamine were determined using non-competitive spectrophotomeric method. Isotopologue 5-F-[(1R)- -2H]-tryptamine, needed for kinetic studies was obtained by enzymatic decarboxylation of 5'-fl uoro-L-tryptophan, 5'-F-L-Trp, in fully deuteriated medium.
- Źródło:
-
Nukleonika; 2014, 59, 3; 91-95
0029-5922
1508-5791 - Pojawia się w:
- Nukleonika
- Dostawca treści:
- Biblioteka Nauki
Artykuł