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    Wyświetlanie 1-2 z 2
    Tytuł:
    Application of neutron activation for investigation of Fe3O4 nanoparticles accumulation by plants
    Autorzy:
    Bystrzejewska-Piotrowska, G.
    Asztemborska, M
    Stęborowski, R.
    Polkowska-Motrenko, H.
    Danko, B.
    Ryniewicz, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/146840.pdf
    Data publikacji:
    2012
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    iron (II,III) oxide
    nanoparticles
    neutron activation
    plants
    Opis:
    As a result of the rapid development of nanotechnology and increasing application of nanoproducts in many areas of everyday life, there is a growing risk of production of nanowastes potentially dangerous for the environment. This makes it necessary to investigate the accumulation and toxicity of nanoparticles (NPs) at different trophic levels. In the studies neutron activation was applied for the investigation of iron (II,III) oxide nanoparticle (Fe3O4-NPs) accumulation by Lepidium sativum and Pisum sativum L. Plants were cultivated on growth medium contaminated with different concentrations (0.01-10 mmolźL-1) of Fe3O4-NPs. For the identification of the presence of Fe3O4-NPs in plant tissues gamma spectrometry following iron oxide (II,III) nanoparticles irradiation was applied. Both plant species were found to accumulate iron (II,III) oxide nanoparticles. The highest content of NPs was found in plant roots, reaching 40 g/kg for Pisum sativum L. More than 90% of accumulated NPs were found in roots. Accumulation of Fe3O4-NPs was found to depend on the concentration of nanostructures in the growth medium. The transfer factor for Lepidium sativum roots and shoots and Pisum sativum L. shoots decreased with increasing NP concentration in the medium; for Pisum sativum L. roots the tendency was reversed. Neutron activation of nanoparticles was shown to be a powerful tool for tracing the environmental fate of NPs and their uptake and accumulation in organisms.
    Źródło:
    Nukleonika; 2012, 57, 3; 427-430
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis and evaluation of radiolabeled, folic acid-PEG conjugated, amino silane coated magnetic nanoparticles in tumor bearing Balb/C mice
    Autorzy:
    Razjouyan, J.
    Zolata, H.
    Khayat, O.
    Nowshiravan, F.
    Shadanpour, N.
    Mohammadnia, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/147452.pdf
    Data publikacji:
    2015
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    superparamagnetic iron oxide nanoparticles (SPIONs)
    (3-aminopropyl) triethoxysilane (APTES)
    poly(ethylene glycol) (PEG)
    folic acid
    KB cells
    copper-64
    Opis:
    To design a potent agent for positron emission tomography/magnetic resonance imaging (PET/MRI) imaging and targeted magnetic hyperthermia-radioisotope cancer therapy radiolabeled surface modified superparamagnetic iron oxide nanoparticles (SPIONs) were used as nanocarriers. Folic acid was conjugated for increasing selective cellular binding and internalization through receptor-mediated endocytosis. SPIONs were synthesized by the thermal decomposition of tris (acetylacetonato) iron (III) to achieve narrow and uniform nanoparticles. To increase the biocompatibility of SPIONs, they were coated with (3-aminopropyl) triethoxysilane (APTES), and then conjugated with synthesized folic acid-polyethylene glycol (FA-PEG) through amine group of (3-aminopropyl) triethoxysilane. Finally, the particles were labeled with 64Cu (t1/2 = 12.7 h) using 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid mono (N-hydroxy succinimide ester) DOTA-NHS chelator. After the characterization of SPIONs, their cellular internalization was evaluated in folate receptor (FR) overexpressing KB (established from a HeLa cell contamination) and mouse fibroblast cell (MFB) lines. Eventually, active and passive targeting effects of complex were assessed in KB tumor-bearing Balb/C mice through biodistribution studies. Synthesized bare SPIONs had low toxicity effect on healthy cells, but surface modification increased their biocompatibility. Moreover, KB cells viability was reduced when using folate conjugated SPIONs due to FR-mediated endocytosis, while having little effect on healthy cells (MFB). Moreover, this radiotracer had tolerable in vivo characteristics and tumor uptake. In the receptor blocked case, tumor uptake was decreased, indicating FR-specifi c uptake in tumor tissue while enhanced permeability and retention effect was major mechanism for tumor uptake.
    Źródło:
    Nukleonika; 2015, 60, No. 3, part 1; 497-502
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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