Temat: etiology - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: CTRC gene polymorphism may increase pancreatic cancer risk – preliminary study
Autorzy:: Głuszek, Stanisław
Kowalik, Artur
Kozieł, Dorota
Wawrzycka, Iwona
Głuszek-Osuch, Martyna
Matykiewicz, Jarosław
Powiązania:: https://bibliotekanauki.pl/articles/1393315.pdf
Data publikacji:: 2017
Wydawca:: Index Copernicus International
Tematy:: pancreatic cancer
CTRC polymorphism
etiology
Opis:: Pancreatic cancer is often fatal due to delayed diagnosis and treatment difficulties. Objective: To analyze selected SPINK1, CTRC, CFTR, and PRSS1 gene mutations in cancer tissue and blood samples of patients with pancreatic tumors. Materials and method: We enrolled 16 consecutive patients diagnosed with pancreatic tumors. We collected cancer tissue, normal pancreatic tissue, and blood samples for genetic tests. The control group consisted of 419 healthy individuals. Peripheral blood samples were collected from all study participants in EDTA-coated tubes. Results: Out of 16 patients with pancreatic tumors, 12 had pancreatic cancer on microscopic examination (mean age, 60.2 years). The CTRC polymorphism Hetero p.G60=(c.180C>T) was found in 5 patients with pancreatic cancer (41.7% vs. 18.6% in the control group). One patient with pancreatic cancer and a positive family history had the SPINK1 (p.N34S) mutation [8.3% vs. 2.9% (12/419) in the control group]. One patient with pancreatic cancer had the CTRC (p.R254W) mutation [8.3% vs. 1% (4/419) in the control group]. Conclusions: Our preliminary results show that the CTRC polymorphism p.G60= (c.180C>T) is frequent in patients with pancreatic cancer. However, further research is needed to verify our findings.
Źródło:: Polish Journal of Surgery; 2017, 89, 5; 48-53
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Congenital cholesteatomas
Autorzy:: Narożny, Waldemar
Kuczkowski, Jerzy
Stankiewicz, Czesław
Powiązania:: https://bibliotekanauki.pl/articles/1401793.pdf
Data publikacji:: 2015
Wydawca:: Index Copernicus International
Tematy:: congenital cholesteatoma
middle ear
etiology
treatment
overview
Opis:: Congenital cholesteatoma is a rare ear disorder. The most common presentation is a pearly and white mass, visible with an intact tympanic membrane in individuals with no previous history of ear discharge, ear surgery or perforation of tympanic membrane. Based on a careful overview of literature, authors of this article present: the most probable theories of the cause of development of congenital cholesteatoma, diagnostic criteria of congenital cholesteatoma, its most common clinical symptoms, preoperative studies, methods of surgical treatments and goals of postoperative proceedings. Furthermore, authors present a comparison of histological, molecular and clinical features of congenital and acquired cholesteatomas.
Źródło:: Polski Przegląd Otorynolaryngologiczny; 2015, 4, 2; 78-83
2084-5308
2300-7338
Pojawia się w:: Polski Przegląd Otorynolaryngologiczny
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Epidemiological Characteristic of Acute Pancreatitis in Trzebnica District
Autorzy:: Bogdan, Justyna
Elsaftawy, Ahmed
Kaczmarzyk, Janusz
Jabłecki, Jerzy
Powiązania:: https://bibliotekanauki.pl/articles/1396706.pdf
Data publikacji:: 2012-02-01
Wydawca:: Index Copernicus International
Tematy:: acute pancreatitis
etiology
severe acute pancreatitis
recurrent pancreatitis
treatment
Opis:: Acute pancreatitis is one of the most common surgical disease, and thus cause of hospitalization. Incidence and etiology of this condition demonstrates large regional differences. This situation is a substantial financial burden forhospital district, and changes in organization structure and funding medical service should be taken under consideration.The aim of the study was to record the epidemiology with etiology, diagnosis and treatment of acute pancreatitis in large district (77 000 inhabitants).Material and methods. A meta-analysis study of all 298 patients admitted to Hospital St Hedwig in Trzebnica, in the six-year period from 2005 to 2010, with acute pancreatitis was performed.Results. Acute pancreatitis was diagnosed in 298 patients in the six - year period, giving an estimated incidence of 64.4 per 100 000. Among the group of 441 admissions for acute pancreatitis in 298 patients was confirmed. Severe acute pancreatitis developed in 22.5% (67/298) of patients, more often in males 56/208 (27%) than in females 11/90 (12%). Gallstones were found as an etiological factor in 27% (80/298), and alcohol intake in 49% of patients. 211/298 (70%) patients had only one attack, whereas 29% (87/298) were readmitted with 230 relapses. The risk of recurrent pancreatitis was 48% in alcohol induced and 6,25% in gallstone induced pancreatitis. 53/298 patients (17%) were operated, ERCP procedures were performed in 24.Performed operations: necrosectomy in 25/53 (47%), elective cholecystectomy in 16/53 (30%), open drainage of abdominal abscess in 5/53 (9%), open drainage of cysts in 5/53 (9%), Jurasz's operation in 2/53 (3%). Majority surgical treatment was carried out in 68% cases with severe acute pancreatitis. Mortality due to acute pancreatitis was 3% (10/298); 15% in severe pancreatitis.Conclusions. 1. Acute pancreatitis continues to be an important clinical problem. 2. Severe, necrotic acute pancreatitis is associated with high mortality rates. 3. The ethanol-intake-related episodes of acute pancreatitits are much more prevalent than the gall-stone-related ones. 4. After the exclusion of ethanol- and gall-stones-related etiologies, the subsequent diagnostic process should aim at excluding neoplastic process of the head of pancreas.
Źródło:: Polish Journal of Surgery; 2012, 84, 2; 70-75
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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