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    Wyświetlanie 1-4 z 4
    Tytuł:
    Allergies, asthma or hypersensitivity to NSAIDs – are they an equally important risk factor for the development of a specific CRS phenotype?
    Autorzy:
    Stryjewska-Makuch, Grażyna
    Janik, Małgorzata
    Kolebacz, Bogdan
    Ścierski, Wojciech
    Lisowska, Grażeyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1397488.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    allergy
    asthma
    hypersensitivity
    nasal surgical procedures
    sinusitis
    Opis:
    Introduction: CRS is a complex systemic disease affecting more than 10% of the population. There are two main types of CRS phenotypes: CRSwNP and CRSsNP. In the Caucasian population, the prevalence of inflammation markers typical of the Th1 profile is observed in CRSsNP, whereas Th2 and Th17 in CRSwNP. Th2 inflammation is observed in the CRSwNP phenotype with concomitant allergies, asthma or hypersensitivity to NSAIDs. Objectives: The aim of the study was to evaluate, based on the authors’ own material, whether allergies, asthma or hypersensitivity to NSAIDs were a risk factor for the development of a specific CRS phenotype. An attempt was also made to investigate the influence of comorbidities on the extent of sinus endoscopic procedures, which depended on the severity of inflammation. Methods: In the years 2006–2015, ESS was performed on 2217 patients with different CRS phenotypes. Patients with an allergy, bronchial asthma and hypersensitivity to NSAIDs were subjected to analysis. Results: Based on logistic regression, it was found that among the mentioned comorbidities, only asthma (P < 0.0001) and hypersensitivity to NSAIDs (P = 0.0007) significantly affect the occurrence of the phenotype with polyps, whereas the impact of allergies is statistically insignificant (P = 0.1909). The relationship between the type of ESS and CRS phenotypes is statistically significant (P < 0.0001). Conclusions: Bronchial asthma and hypersensitivity to NSAIDs have a statistically significant effect on the occurrence of the CRSwNP phenotype. This effect was not observed in allergies. The impact of allergies, asthma and hypersensitivity on the phenotype was observed in the group of patients subjected to the most extensive surgery (ESS 4).
    Źródło:
    Polish Journal of Otolaryngology; 2020, 74, 2; 8-16
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Auditory hypersensitivity – definition, etiology, etiopathogenesis, diagnostic and therapeutic possibilities
    Autorzy:
    Czarnecka, Emilia
    Lachowska, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/1399061.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    auditory hypersensitivity
    hyperacusis
    misofonia
    phonophobia
    uncomfortable hearing level
    Opis:
    Introduction: Auditory hypersensitivity is a phenomenon difficult to define for several reasons. The most important obstacle to the formulation of a clear definition is the terminology complexity, variety reported symptoms, their subjectivity and circumstances of occurrence. Abnormalities in auditory, physiological and psychological processes are connected with auditory hypersensitivity. Despite the wide range of diagnostic tests, managing a patient with this disorder is not an easy task. Aim: The review explains the causes of inconsistencies in the terminology associated with this phenomenon, lists the types of auditory hypersensitivity mentioned in the latest literature, presents available epidemiological data and characterizes the most important diseases accompanied by auditory hypersensitivity. In addition, difficulties in determining the etiology and potential mechanisms for auditory hypersensitivity in subjects with no hearing impairment have been described. The paper also presents methods of diagnosis and treatment options proposed in the literature.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2020, 9, 2; 27-34
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Chronic cough: new concepts and therapeutic possibilities
    Autorzy:
    Arcimowicz, Magdalenia
    Niemczyk, Kazimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1401753.pdf
    Data publikacji:
    2016
    Wydawca:
    Index Copernicus International
    Tematy:
    cough
    chronic cough
    upper airway cough syndrome
    Cough Hypersensitivity Syndrome
    diagnosis
    therapy
    Opis:
    Cough is the most common symptom of the upper and lower airway diseases. In its nature, cough is a defence re-flex mechanism of the respiratory tract that is used to clear the upper and lower airways. Chronic cough, defined as cough lasting for more than 8 weeks, is reported in 3–40% of the general population and has an important impact on patients’ quality of life, by causing anxiety, physical discomfort, social isolation and personal emabarrassment, be-ing an often medical complaint and one of the most common reasons for outpatient visits. Upper airway cough syn-drome, asthma, eosinophilic bronchitis and gastroesophageal reflux diseases account for most chronic cough after excluding somking, angiotensin-converting enzyme inhibitor use and chronic bronchitis. Many patients have more than one reason for chronic cough. Some complex diagnostic procedures, in many individuals are necessary to rec-ognized the cause/causes of chronic cough and to establish the accurate diagnosis, which implies a higher chance of effective treatment. Despite detailed diagnostic procedures, in many cases, the efficacy of chronic cough treatment is questionable and ambiguous. We observe not always satisfactory response to therapy. There are some coughs that seem refractory despite an extensive work-up. The possibility of hypersenitive cough reflex response, defining pa-tients with Cough Hypersensitivity Syndrome has been proposed to explain these cases, rather resistant to cough treatment, previously known as idioapthic cough or refractory, unexplained cough. The concept of Cough Hypersen-sitivity Syndrome helps us to understand the mechanisms underlying cough and provides better therapeutic options to treat chronic cough, like neuromodulating drugs, and speech therapy.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2016, 5, 1; 22-29
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of the impact of bronchial asthma and hypersensitivity to aspirin on the clinical course of chronic sinusitis with nasal polyps
    Autorzy:
    Podwysocka, Marta
    Dąbrowska, Katarzyna
    Fendler, Wojciech
    Pagacz, Konrad
    Pietruszewska, Wioletta
    Powiązania:
    https://bibliotekanauki.pl/articles/1397802.pdf
    Data publikacji:
    2019
    Wydawca:
    Index Copernicus International
    Tematy:
    chronic sinusitis with nasal polyps
    hypersensitivity to aspirin
    bronchial asthma
    clinical course
    treatment
    Opis:
    Chronic rhinosinusitis with nasal polyps (CRSwNP) is a disease with still not enough known pathogenesis despite the development of genetics, immunological and microbiological research. The number of patients with CRS has been constantly growing. The coexistence of CRS, bronchial asthma and aspirin intolerance (aspirin triad) is an adverse prognostic factor with higher risk of recurrences. The aim of study was to compare the severity of CRSwNP depending of coexistence of bronchial asthma and/or aspirin intolerance. The research was performed in the group of 204 patients operated 2009-2013 with 5 years follow-up. Higher nasal polyps growth in groups of patients with aspirin triad and CRSwNP and bronchial asthma in endoscopic examination (p=0,0005 and p=0,0030 respectively) and CT-scan according to Lund-Mackay point scale (p<0,0001 and p=0,0009) was showed. Also, these patients presented increased severity of nasal symptoms before surgical treatment according to VAS scale (p=0,0126 for CRSwNP with bronchial asthma; p=0,0390 for aspirin triad). Similarly, 6 months after surgery the same groups of patients presented higher severity of the disease symptoms (p<0,0001 for aspirin triad’ patients; p=0,0174 for CRSwNP and bronchial asthma’ patients) . Patients with aspirin triad had also statistically more surgeries in past (p=0,001), what proves that recurrences in this group are very likely to be observed in spite of the use of proper conservative treatment. No such differences have been shown in the group of patients with CRSwNP and isolated aspirin intolerance (without bronchial asthma). Allergy to inhaled allergens, hypersensitivity to aspirin are factors significantly worsening the course of CRSwNP. It would be advisable to consider, despite a lack of history of aspirin intolerance, a hypersensititvity to aspirin test in patients with particularly severe CRSwNP, especially those associated with bronchial asthma. It also seems reasonable to carry out such a test on every patient with newly diagnosed CRSwNP and bronchial asthma in order to be able to plan further treatment in this group of patients accordingly including biological treatment with antimonoclonal therapy against interleukin 4, 5 or13.
    Źródło:
    Polish Journal of Otolaryngology; 2019, 73, 5; 37-43
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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