- Tytuł:
- Dynamic bubble tensiometry as a useful tool for assessment of physicochemical interactions of liposomal drug carriers with respiratory tract
- Autorzy:
-
Kramek-Romanowska, K.
Sosnowski, T. R. - Powiązania:
- https://bibliotekanauki.pl/articles/115811.pdf
- Data publikacji:
- 2015
- Wydawca:
- Fundacja na Rzecz Młodych Naukowców
- Tematy:
-
pulmonary surfactant
liposomes
inhalation
surface tension
adsorption
surfaktant płucny
liposomy
inhalacja
napięcie powierzchniowe
adsorpcja - Opis:
- This article presents an experimental investigation of physicochemical interactions of novel liposomal drug carriers intended for inhalation with model lung surfactant system. The research was done with the use of maximum bubble pressure (MBP) method to measure changes of dynamic surface tension of pulmonary surfactant system after contact with liposomal colloids made of lecithin and lecithin/cholesterol (3:1 w/w) before and after 5 and 10 minutes of nebulisation by pneumatic nebulizer. What is important to point, MBP method allows the discussion of measured phenomena with reference to the time scales characteristic for the changes of alveolar surface area during the breathing cycle. Obtained results may have a potential application during design and development of new therapeutic liposomal formulations for treatment of respiratory as well as systemic diseases.
- Źródło:
-
Challenges of Modern Technology; 2015, 6, 4; 23-26
2082-2863
2353-4419 - Pojawia się w:
- Challenges of Modern Technology
- Dostawca treści:
- Biblioteka Nauki
Artykuł