- Tytuł:
- Biocompatibility of L-lactide-co-glycolide-co-trimethylene-carbonate shape memory terpolymer with human chondrocytes
- Autorzy:
-
Kłosek, R.
Komacki, J.
Orchel, A.
Jelonek, K.
Dobrzyński, P.
Kasperczyk, J.
Dzierżewicz, Z. - Powiązania:
- https://bibliotekanauki.pl/articles/284055.pdf
- Data publikacji:
- 2012
- Wydawca:
- Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
- Tematy:
-
shape-memory polymers (SMP)
biodegradable polymers
cytotoxicity
degradation products
in vitro
biocompatibility of terpolymer - Opis:
- Biomedical application of biodegradable shape memory terpolymers obtained from L-lactide, glycolide, trimethylene carbonate (TMC) have been intensively investigated in recent years. All applicable biomedical materials must be biocompatible, which means that they cannot cause toxic, cytotoxic, allergic, or carcinogenic reactions. The first study evaluating the biocompatibility of the material is determination of its cytotoxicity. The purpose of this study was to assess the biocompatibility of poly(L-lactide-co-glycolide-co-trimethylene-carbonate) 75:13:12, synthesized using Zr(Acac)4 as an initiator of polymerization. The terpolymer was degraded for 30, 60 and 90 days at 37§C in water. The effect of degradation products on the growth of human articular chondrocytes was determined using the sulforhodamine B assay. The examined terpolymer was characterized by means of NMR spectroscopy, GPC and DSC. The results showed that the studied terpolymer was biocompatible with tested cells.
- Źródło:
-
Engineering of Biomaterials; 2012, 15, 113; 23-25
1429-7248 - Pojawia się w:
- Engineering of Biomaterials
- Dostawca treści:
- Biblioteka Nauki
Artykuł