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    Wyświetlanie 1-3 z 3
    Tytuł:
    An overview of paraneoplastic neurological syndromes – pathophysiology and clinical insight
    Autorzy:
    Kwiatkowski, Stanisław
    Kolasińska, Karolina
    Knap, Bartosz
    Przystupski, Dawid
    Kotowski, Krzysztof
    Bartosik, Weronika
    Kulbacka, Julita
    Powiązania:
    https://bibliotekanauki.pl/articles/1163959.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    dermatomyositis
    encephalitis
    opsoclonus-myoclonus
    paraneoplastic neurological syndromes
    Opis:
    Paraneoplastic syndrome (PS) is a dysfunction of organs or systems, associated with neoplastic disease, but not related to the local growth of tumor, metastasis or adverse anti-cancer drugs reactions. Neurological paraneoplastic syndromes (NPSs) may affect every region of a human nervous system - both central, peripheral, and/or autonomic nervous system. The symptoms are caused by a neoplastic process in other organ or system. PNSs usually precede the development of cancer for months or even years, and can be therefore useful diagnostic markers of cancer. They present an autoimmune background associated with the response of the immune system against cancer cells. In the blood serum and cerebrospinal fluid of patients with PNS appear onconeural antibodies, reacting with tumor antigens and the brain, the spinal cord and peripheral ganglia antigens. Many authors emphasize the significance of paraneoplastic syndromes in the modern oncology. Due to this reason, the knowledge of paraneoplastic syndromes and their mechanisms is very important in the contemporary medicine. The purpose of this research review is to summarize the information about the clinical features of the most common PNSs and the pathological mechanisms of their development.
    Źródło:
    World Scientific News; 2018, 108; 87-98
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    GcMAF: a polemic or a highly promising molecule?
    Autorzy:
    Eric Matamoros, Morales
    Powiązania:
    https://bibliotekanauki.pl/articles/1182805.pdf
    Data publikacji:
    2017
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    HIV
    Vitamin D binding protein-macrophage activating factor
    cancer
    controversies
    neurological disorders
    vitamin D binding protein
    α-N-acetylgalactosaminidase
    Opis:
    Vitamin D Binding Protein (DBP) is a multifunctional protein which main role is to carry vitamin D and its metabolites, but it also acts as an actin scavenger and is the precursor of the macrophage activating factor molecule (GcMAF), which has reported highly promising results against cancer, HIV, and neurological disorders including autism, Alzheimer disease, Chronic Fatigue Syndrome (CFS), among others. DBP leads to the formation of GcMAF due to the loss of the O-glycosylated oligosaccharide moiety of the peptide by glycohydrolysis mediated by T and B cells. Some of the current noticed diseases have got increased levels of α-N-acetylgalactosaminidase (Nagalase), a molecule that deglycosylates DBP so it cannot drive to GcMAF, leading to immunosuppression. In this review we take a close look at the state of art strategies and trials using GcMAF as well as the controversies that have emerged during the last decade with this ‘polemic’ molecule.
    Źródło:
    World Scientific News; 2017, 65; 20-36
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Radiologically Isolated Syndrome – a not so rare prelude to Multiple Sclerosis
    Autorzy:
    Kulczyński, Marcin
    Sapko, Klaudia
    Papuć, Ewa
    Marciniec, Michał
    Dyndor, Katarzyna
    Pankowska, Anna
    Pietura, Radosław
    Rejdak, Konrad
    Powiązania:
    https://bibliotekanauki.pl/articles/1164263.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    biomarkers
    cerebro-spinal fluid
    cognitive impairment
    demyelinating diseases
    disability
    headache
    magnetic resonance imaging
    multiple sclerosis
    neurological disorders
    radiologically isolated syndrome
    Opis:
    Radiologically isolated syndrome (RIS) was defined for the first time in 2009 with an attempt to establish objective criteria of diagnosis for the patients, who underwent brain MRI scanning for a reason other than multiple sclerosis (MS), but were found to have white matter lesions in their central nervous systems (CNS) similar to those present in patients with diagnosed MS. RIS has been defined as separate entity with the presence of MRI findings strongly suggestive of MS in a patient with no neurological manifestations or other clear-cut explanation. Healthy patients may have an initial MRI procedure performed due to different reasons other than suspicion of MS, mainly because of headaches. However, a clinical examination does not reveal any signs of focal neurological deficits and there are no evidence for the focal damage in the CNS in these patients as well. Although RIS is not the first stage of multiple sclerosis in every patient, 30 up to even 45% of individuals diagnosed with this condition will present clinical symptoms in the future, within median time from 2.3 to 5.4 years depending on various researches. Most authors agree, that about 1/3 of patients with RIS will convert to clinically definite MS within 5 years of follow-up. There are some significant predictors of conversion, among others - presence of lesions in cervical and thoracic spinal cord. Moreover, patients with RIS, although asymptomatic in the meaning of classic clinical presentation of MS, are proved to experience early axonal loss, brain atrophy, increased anxiety and depression and subclinical inflammatory disease, as well as some signs of cognitive impairment. In this article we aim to make a review of the newest papers published in 2017 and 2018 concerning Radiologically Isolated Syndrome.
    Źródło:
    World Scientific News; 2018, 107; 1-11
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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