- Tytuł:
- Computational study of ACE and AGT gene of RAAS pathway
- Autorzy:
-
Nisha, Nisha
Kaur, Satbir
Kaur, Sumanpreet
Kumar, Sandeep
Galhna, Kiranjeet Kaur
Kaur, Kamaljeet - Powiązania:
- https://bibliotekanauki.pl/articles/1112240.pdf
- Data publikacji:
- 2018
- Wydawca:
- Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
- Tematy:
-
Angiotensin converting enzyme
Angiotensinogen
Hypertension
Renin angiotensin aldosterone system
Single nucleotide polymorphism - Opis:
- Renin angiotensin aldosterone system (RAAS) is a hormone regulatory hormone system that regulate blood pressure. The two major genes ACE and AGT are the players of RAAS pathway. These genes codes for angiotensin convertase enzyme and angiotensinogen protein respectively. The angiotensin convertase enzyme convert inactive angiotensinogen into active angiotensin which further helps in the regulation of blood pressure. Due to imbalance in this pathway may cause hypertension. So in the present study we decided to perform the computational study of ACE and AGT gene. We evaluated the deleterious/damaging effect of SNPs of ACE and AGT gene by SIFT and I-Mutant2.0. The total number of SNPs predicted to be deleterious by both tools were 5 (1.83%) and 22 (6.07%) for AGT and ACE genes respectively. We also studied subcellular location of ACE and AGT genes and drugs targeting these genes from database GeneCards. Further the result output of both the softwares were also compared.
- Źródło:
-
World News of Natural Sciences; 2018, 19; 65-77
2543-5426 - Pojawia się w:
- World News of Natural Sciences
- Dostawca treści:
- Biblioteka Nauki
Artykuł